Mazdutide
Mazdutide is a dual GLP-1 and glucagon receptor agonist studied for its role in appetite regulation, glycemic control, and energy expenditure signaling. By simultaneously activating incretin and glucagon pathways, it influences central satiety circuits and peripheral metabolic processes. In clinical research, Mazdutide has been observed to support body weight reduction and metabolic modulation in structured trial settings. Formulated in a stabilized pre-mixed injection pen for research use only.
151,00 €
Mazdutide - Appetite Regulation & Energy Expenditure
Description
Mazdutide is a synthetic dual agonist targeting both GLP-1 and glucagon receptors, designed to integrate incretin-mediated satiety signaling with glucagon-associated energy expenditure pathways. Unlike single-pathway GLP-1 receptor agonists, Mazdutide engages complementary mechanisms influencing appetite suppression and metabolic rate regulation. It is primarily studied in obesity, metabolic syndrome, and type 2 diabetes research contexts.
Our formulation is provided in a stabilized pre-mixed injection pen for SubQ administration. Subcutaneous delivery supports controlled systemic exposure and predictable pharmacodynamic activity in experimental protocols. Each unit is freshly prepared to preserve peptide integrity and standardized dosing. The product is intended strictly for laboratory and research use only.
In clinical and preclinical models, Mazdutide has demonstrated effects on appetite reduction, improved glycemic markers, and body weight modulation. Activation of GLP-1 receptors influences insulin secretion and satiety signaling, while glucagon receptor activation contributes to hepatic glucose output modulation and increased energy expenditure. Research domains include metabolic regulation, adiposity reduction studies, and cardiometabolic risk factor evaluation.
Clinical Status
Human RCT ✔ | Observational ✔ | Animal ✔ | In vitro ✔
Currently evaluated in multiple human clinical trials for obesity and metabolic disorders.
Mechanism of Action
Mazdutide activates both GLP-1 and glucagon receptors, integrating appetite suppression with metabolic rate modulation. GLP-1 receptor activation influences satiety signaling within hypothalamic circuits and enhances glucose-dependent insulin secretion. Glucagon receptor engagement contributes to increased energy expenditure and modulation of hepatic metabolic pathways. The combined mechanism supports coordinated metabolic regulation in research models.
Benefits
- Integrated appetite suppression and metabolic regulation:
Mazdutide combines incretin-based satiety signaling with glucagon-mediated metabolic activation. Activation of central GLP-1 receptors influences appetite control within hypothalamic nuclei involved in energy homeostasis. Clinical trials demonstrate reduced caloric intake and sustained body weight reduction in structured research settings. The addition of glucagon receptor engagement supports complementary metabolic effects. This integrated mechanism differentiates Mazdutide from single-pathway GLP-1 agonists. - Enhanced glycemic control through incretin signaling:
GLP-1 receptor activation promotes glucose-dependent insulin secretion from pancreatic beta cells. This mechanism supports improved postprandial glycemic control in metabolic research populations. Slowed gastric emptying further contributes to moderated glucose excursions. These combined effects underpin its positioning within metabolic disorder research. - Energy expenditure modulation via glucagon receptor activation:
Glucagon receptor engagement influences hepatic metabolic processes and lipid oxidation pathways. Preclinical models suggest increased energy expenditure associated with glucagon pathway stimulation. This mechanism aims to counterbalance reductions in metabolic rate often observed during weight loss interventions. The thermogenic component distinguishes dual agonism strategies. - Reduction of adiposity in structured research settings:
Clinical investigations report meaningful reductions in body weight and adipose tissue mass. These outcomes are linked to coordinated appetite suppression and metabolic rate modulation. Dual receptor activation supports sustained metabolic engagement beyond appetite control alone. - Potential influence on cardiometabolic risk markers:
Research indicates improvements in lipid profiles and glycemic indices during clinical evaluation. While primarily studied for weight reduction, metabolic improvements extend to broader cardiometabolic parameters. These findings support its inclusion in obesity-related research protocols. - Balanced dual agonism strategy:
Mazdutide is engineered to balance GLP-1 and glucagon receptor activation to optimize therapeutic effect while minimizing excessive glucagon-mediated hyperglycemia. The molecular design aims to harmonize satiety and energy expenditure pathways. This balanced co-agonism approach represents a next-generation incretin strategy in metabolic research. - Predictable subcutaneous pharmacokinetics:
Provided in a stabilized pre-mixed injection pen for SubQ administration, Mazdutide demonstrates consistent systemic exposure in clinical trial settings. Subcutaneous delivery supports structured dosing regimens and reproducible pharmacodynamic responses. Each unit is freshly prepared and intended strictly for laboratory use only.
Research Data
| Study / Model | Reported effect |
|---|---|
| Phase 3 trial in Chinese adults with obesity (GLORY-1) | ↓ body weight by ~14% at 48 weeks with 6 mg dose vs placebo |
| Phase 2 trial in type 2 diabetes | ↓ HbA1c by ~1.5-2.0%, ↓ fasting glucose, ↑ glycemic control |
| Diet-induced obese mouse models | ↓ food intake, ↑ energy expenditure, ↓ hepatic lipid content |
| Clinical metabolic assessments | ↓ liver fat fraction, improved lipid profile, ↓ waist circumference |
| Receptor binding studies (in vitro) | Confirmed dual GLP-1R and GCGR activation with balanced potency |
| Cardiometabolic biomarker analysis | ↓ triglycerides, ↓ LDL cholesterol, improved blood pressure markers |
Stack Suggestions
Mazdutide is often combined in research with:
- Mazdutide + Rеtаtrutіdе → Comparative studies exploring dual versus triple incretin receptor activation in metabolic models.
- Mazdutide + Tesofensine → Investigates combined central appetite suppression with incretin-glucagon signaling pathways.
- Mazdutide + BPC-157 → Pairs metabolic modulation with gastrointestinal cytoprotective research applications.
- Mazdutide + AOD-9604 → Explores complementary lipolytic and incretin-driven body composition pathways.
- Mazdutide + NAD+ → Combines mitochondrial energy substrate research with glucagon-mediated thermogenic signaling.
⚠ Stacks are for experimental design only; not safety or efficacy guidance.
Pen Dosage Chart
| Mazdutide Pen 5 mg | |
|---|---|
| Volume | 2 mL |
| mg/mL | 2.5 mg/mL |
| Click-to-Dose | 1 click = 0.025 mg |
| Example(s) | 10 clicks = 0.25 mg |
Dosage & Protocols Variations
Standard Research Protocol
- Dose: 3 – 4.5 mg (= 120–180 clicks)
- Duration: 8 – 12 weeks
- Frequency: Once weekly
- Cycle Interval: 4 weeks off before repeating
- Goal / Description: Baseline dosing used in metabolic and appetite-regulation research models.
Therapeutic Research Protocol
- Dose: 6 – 9 mg
- Duration: 12 – 24 weeks
- Frequency: Once weekly
- Cycle Interval: 4 – 6 weeks off before repeating
- Goal / Description: Higher-dose protocol targeting glycemic control and body composition endpoints.
Biohacker Protocol (experimental)
- Dose: 1.5 – 3 mg (= 60–120 clicks)
- Duration: 6 – 10 weeks
- Frequency: Once weekly, titrated upward
- Cycle Interval: 2 – 4 weeks off before repeating
- Goal / Description: Microdosed titration approach minimizing gastrointestinal adaptation effects.
Possible Side Effects
Mazdutide is generally well-tolerated in clinical and preclinical studies, with most reported effects being mild to moderate and dose-dependent.
Commonly observed effects include:
- Gastrointestinal disturbances such as nausea, vomiting, and diarrhea, particularly during dose escalation.
- Decreased appetite and transient reductions in food intake.
- Mild increases in heart rate reported in some clinical trials.
- Occasional dyspepsia, bloating, or abdominal discomfort.
- Injection-site reactions including redness or mild irritation.
No evidence of severe hepatic, renal, or cardiovascular adverse effects has been observed in available data, though long-term safety remains under continued investigation.
Product Attributes
- CAS #: 2107529-15-7
- Molecular Formula: C194H295N47O59
- Sequence (AA): HSQGTFTSDYSKYLDEKRAKDFVQWLLNT (modified dual agonist analog)
- Molecular Weight: ~4332 g/mol
- PubChem CID: N/A (investigational compound)
- Half-Life: ~6-8 days
- Synonyms: IBI362, LY3305677, Mazdutide
- Type: Synthetic dual GLP-1 / glucagon receptor agonist peptide
- Research Focus: Metabolism & Weight Regulation, Glycemic Control, Energy Expenditure
Scientific References
- Mazdutide for overweight or obesity in Chinese adults: a randomized, double-blind, placebo-controlled phase 2 trial Human RCT
- A phase 1 randomized trial to evaluate safety, pharmacokinetics, and pharmacodynamics of IBI362 (LY3305677) in Chinese overweight or obese adults Human RCT
- Efficacy and safety of mazdutide in Chinese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 2 trial Human RCT
- OXM-based dual GLP-1/glucagon receptor agonists for the treatment of obesity and metabolic disease Observational | Animal | In vitro
- Dual glucagon-like peptide-1 and glucagon receptor agonism reduces energy intake in type 2 diabetes with obesity Human RCT
- Glucagon-like peptide-1 and glucagon receptor co-agonists: novel therapeutics for obesity and type 2 diabetes Animal | In vitro
- Anti-obesity drug discovery: advances and challenges Observational | Animal
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.
For this reason, we accept mainly Bank Transfers.
We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.
Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.
This method ensures compliance, security, and continuity of service for all customers across the EU.
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