Vesugen
Vesugen is a synthetic short-chain peptide bioregulator composed of three amino acids (Lys-Glu-Asp), developed within the field of vascular peptide research. It is investigated for its potential to support vascular endothelium integrity, modulate gene expression in vascular cells, and influence pathways linked to circulatory function and cellular aging.
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Description
Vesugen is a synthetic tripeptide composed of the amino acid sequence Lys-Glu-Asp (KED), classified within the family of short peptide bioregulators developed for vascular and endothelial research. It is studied for its capacity to influence vascular wall integrity, endothelial cell function, and gene expression related to cardiovascular tissues.
In experimental models, Vesugen has been observed to support endothelial regeneration, modulate vascular tone, and reduce markers of endothelial dysfunction. Research suggests upregulation of eNOS expression and improved nitric oxide bioavailability, which contribute to enhanced microcirculation and vessel elasticity in aged tissue samples.
Additional studies have explored Vesugen’s role in anti-aging vascular research, where it appears to influence telomerase activity and fibroblast proliferation, supporting cellular renewal in connective and vascular tissues. Its short sequence allows efficient cellular uptake and direct interaction with DNA regulatory regions in laboratory settings.
Supplied as a lyophilized powder for reconstitution, Vesugen is formulated for subcutaneous administration in research protocols and offers stable handling characteristics under standard laboratory storage conditions.
Clinical Status:
Vesugen is a research peptide bioregulator evaluated primarily in Russian preclinical and limited observational studies focused on vascular aging, endothelial function, and cardiovascular regeneration. It is not approved for medical use and remains restricted to experimental and laboratory research.
Evidence type:
Human RCT ☐ | Observational ✔ | Animal ✔ | In vitro ✔ | Regulatory ☐
Mechanism of Action
Vesugen works by interacting with vascular endothelial cells, where it has been observed to regulate gene expression linked to vascular tone, endothelial integrity, and nitric oxide signaling. As a short peptide bioregulator, it modulates the transcription of proteins involved in vessel wall maintenance, supporting endothelial function and reducing markers of oxidative stress in experimental models.
Benefits
- Vascular Endothelial Support:
Vesugen has been investigated as a short bioregulator peptide with selective affinity for vascular endothelial tissue. Research models suggest it interacts with regulatory regions of DNA in endothelial cells, potentially influencing the expression of proteins involved in vessel wall integrity. This targeted activity is the central reason Vesugen is studied in the context of cardiovascular and microcirculatory research. - Endothelial Cell Renewal:
Experimental studies have observed that Vesugen appears to stimulate proliferation and functional restoration of aged or damaged endothelial cells. By supporting the renewal of the endothelium, this peptide is studied for its potential to maintain elasticity and reactivity of the vascular lining. Such effects are of interest in models exploring age-related vascular decline. - Microcirculation Modulation:
Vesugen is reported to influence microvascular dynamics, with research models showing improved capillary function and tissue perfusion. By supporting nitric oxide pathways and endothelial responsiveness, the peptide has been studied for its role in optimizing oxygen and nutrient delivery at the tissue level. This makes it a focus in research on circulation and small-vessel function. - Anti-Atherogenic Research Interest:
Preclinical investigations have evaluated Vesugen for its potential to modulate vascular inflammation and reduce markers associated with atherogenic processes. The peptide has been observed to influence lipid handling and endothelial activation in experimental settings. These findings position Vesugen as a candidate in research focused on vascular aging and plaque-related pathophysiology. - Blood Pressure Regulation Studies:
Animal and observational studies have examined Vesugen for its effects on vascular tone and arterial pressure regulation. By supporting endothelial nitric oxide production and vascular relaxation, the peptide is studied for its potential to stabilize hemodynamic parameters. This area of research is particularly relevant in models of hypertension and age-related vascular stiffness. - Coagulation and Hemostasis Balance:
Vesugen has been investigated for its modulatory influence on coagulation factors and platelet aggregation in experimental models. Research suggests it may help maintain a balanced hemostatic profile by supporting healthy endothelial signaling. This effect is of interest in studies exploring thrombosis risk associated with vascular dysfunction and aging. - Anti-Aging Vascular Effects:
As part of the broader Khavinson bioregulator family, Vesugen has been studied for its potential to slow biological aging processes within the vascular system. Research models indicate it may influence telomere-related pathways and gene expression patterns associated with endothelial senescence. These findings make Vesugen a frequent subject in longevity and geroprotective research. - Synergy with Other Bioregulator Peptides:
Vesugen is often investigated alongside other short peptide bioregulators such as Epitalon, Pinealon, and Cardiogen in complex research protocols. Studies suggest that combined use may produce broader systemic effects by targeting multiple tissue-specific regulatory pathways simultaneously. This positions Vesugen as a key component in multi-peptide experimental designs focused on aging and vascular health.
Research Data
| Study / Model | Reported effect |
|---|---|
| Aged rat vascular tissue | ↑ endothelial regeneration markers; improved capillary density |
| Human umbilical vein endothelial cell (HUVEC) culture | ↑ proliferation rate and ↓ senescence-associated markers |
| Atherosclerosis animal model | ↓ plaque progression; improved vascular wall integrity |
| Elderly cohort observational study | Improved microcirculation and reduced markers of vascular aging |
| In vitro telomere assay | Telomerase activity preservation in endothelial lineages |
| Hypertensive rat model | ↓ systolic pressure; ↑ nitric oxide bioavailability |
| Diabetic vascular complication model | Reduced endothelial dysfunction and oxidative stress markers |
Stack Suggestions
Vesugen is often combined in research with:
- Vesugen + Epitalon → Synergistic vascular and longevity research targeting endothelial integrity and telomere maintenance.
- Vesugen + Pinealon → Supports combined neurovascular protection and cognitive resilience models.
- Vesugen + GHK-Cu → Enhances vascular remodeling and connective tissue repair pathways.
- Vesugen + BPC-157 → Combines angiogenic stimulation with broader tissue regeneration research.
⚠ Stacks are for experimental design only; not safety or efficacy guidance.
Pen Dosage Chart
| Vesugen Pen 20 mg | |
| Volume | 2 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.1 mg |
| Example(s) | 10 clicks = 1 mg |
Dosage & Protocols Variations
Standard Research Protocol
- Dose: 100 – 200 mcg
- Duration: 4 – 6 weeks
- Frequency: Daily, sublingual or SubQ
- Cycle Interval: 4 – 8 weeks off before repeating
- Goal / Description: Baseline protocol for vascular function and endothelial integrity studies.
Therapeutic Research Protocol
- Dose: 200 – 400 mcg
- Duration: 6 – 8 weeks
- Frequency: Daily
- Cycle Interval: 8 weeks off before repeating
- Goal / Description: Extended protocol used in models targeting vascular aging and microcirculation.
Biohacker Protocol (experimental)
- Dose: 50 – 100 mcg
- Duration: 8 – 12 weeks
- Frequency: Daily, low-dose sublingual
- Cycle Interval: Continuous with 2-week pauses every 12 weeks
- Goal / Description: Microdose approach explored in longevity-oriented vascular research.
Possible Side Effects
Vesugen is generally well-tolerated in preclinical and limited observational studies.
Reported side effects are rare and mild:
- Mild localized irritation at the injection site.
- Transient headache during initial dosing periods.
- Occasional digestive sensitivity in sensitive subjects.
- Slight fatigue reported in early observational use.
No evidence of hormonal, hepatic, or systemic adverse effects has been observed in available research data. As a short tripeptide bioregulator, Vesugen is structurally similar to endogenous peptide fragments, which is associated with its low reported toxicity profile in experimental models.
Product Attributes
- CAS #: 161258-30-6
- Molecular Formula: C15H26N4O8
- Sequence (AA): KED
- Molecular Weight: 390.4 g/mol
- PubChem CID: N/A (tripeptide bioregulator)
- Half-Life: ~20-30 minutes (short peptide)
- Synonyms: Lys-Glu-Asp, KED peptide, Vascular Peptide Bioregulator
- Type: Synthetic short-chain peptide bioregulator (vascular)
- Research Focus: Vascular Health & Endothelial Function, Longevity & Cellular Regulation
Scientific References
- Vascular wall peptide bioregulator prevents the H2O2-induced damage of endothelial cells Animal | In vitro
- Peptide KED: molecular-genetic aspects of neuroendocrine system regulation in aging In vitro
- Short peptides stimulate cell regeneration suppressed in elderly after stress exposure Animal | In vitro
- Peptidergic regulation of cell differentiation in 3D cell cultures In vitro
- Tripeptide KED induces vasoprotective and antioxidant gene expression in vascular endothelium In vitro
- Short peptides and telomere length regulator hTERT gene expression In vitro
- Geroprotective effects of short peptides in aging vascular research models Observational | Animal
- Molecular aspects of peptide bioregulation in vascular and endothelial tissue Observational | In vitro
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.
For this reason, we accept mainly Bank Transfers.
We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.
Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.
This method ensures compliance, security, and continuity of service for all customers across the EU.
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