Pinealon
Pinealon is a synthetic tripeptide bioregulator composed of the amino acid sequence Glu-Asp-Arg, originally developed from pineal gland peptide research. It has been studied for its potential to support neuronal function, cognitive performance, and cellular longevity. Investigated in experimental models for its role in oxidative stress modulation, gene expression regulation, and neuroprotection.
59,00 €
Pinealon - Cognitive Function & Neuroprotection Bioregulator
Description
Pinealon is a synthetic short peptide bioregulator composed of three amino acids (Glu-Asp-Arg), developed within the Russian peptide research tradition pioneered by Khavinson. It is investigated for its neuroprotective, cognitive, and cellular regulatory properties, with particular focus on central nervous system function and aging-related decline.
In experimental models, Pinealon has been observed to cross the blood-brain barrier, modulate gene expression in neuronal cells, and protect against oxidative stress and excitotoxicity. Research suggests it influences serotonin metabolism, reduces apoptosis in stressed neurons, and supports synaptic plasticity through epigenetic mechanisms involving histone modification and selective gene activation.
Additional studies report antioxidant effects, attenuation of age-related cognitive decline, and improvements in attention and reaction time in animal and limited human observational research. Pinealon is also studied for its potential role in regulating circadian rhythm and pineal gland function.
Supplied as a lyophilized powder for reconstitution, Pinealon is formulated for laboratory research applications requiring precise dosing and stable storage conditions.
Clinical Status:
Pinealon is a research peptide bioregulator studied primarily in Russian preclinical and limited observational research for neuroprotection and cognitive function. It is not approved for medical use and remains restricted to experimental and laboratory research.
Evidence type:
Human RCT ☐ | Observational ✔ | Animal ✔ | In vitro ✔ | Regulatory ☐
Mechanism of Action
Pinealon exerts its activity through cell-penetrating tripeptide signaling, where the Glu-Asp-Arg sequence is reported to cross the blood-brain barrier and enter neuronal nuclei directly. It is investigated for its ability to bind regulatory regions of DNA, modulating gene expression linked to neuronal survival and antioxidant defense. Research models indicate upregulation of protective enzymes, reduction of oxidative stress markers, and stabilization of mitochondrial function in aging and hypoxic conditions.
Benefits
- Cognitive Function Support:
Pinealon has been investigated for its potential to enhance cognitive performance in aged and stressed animal models. Studies report improvements in memory consolidation, attention span, and learning capacity, attributed to its ability to cross the blood-brain barrier and reach neuronal nuclei. The tripeptide is believed to regulate gene expression linked to neuronal plasticity and synaptic transmission, supporting overall brain function in research contexts. - Neuroprotective Activity:
Experimental models have observed Pinealon to exert neuroprotective effects against oxidative stress, hypoxia, and excitotoxicity. By modulating apoptotic pathways and reducing reactive oxygen species accumulation, the peptide appears to safeguard neurons from degenerative damage. This positions Pinealon as a focus of research into age-related neurodegeneration and neuronal resilience under metabolic stress. - Anti-Aging and Longevity Research:
As a bioregulator peptide, Pinealon is studied for its influence on cellular aging and lifespan extension in model organisms. Reports indicate restoration of pineal gland function, normalization of melatonin rhythms, and modulation of telomerase activity. These observations contribute to ongoing research on systemic aging, circadian regulation, and epigenetic modulation in geriatric models. - Sleep and Circadian Rhythm Modulation:
Pinealon’s structural relationship to the pineal gland has prompted investigation into its effects on circadian regulation. Research models show improved melatonin secretion patterns and normalization of sleep-wake cycles, particularly in subjects with disrupted rhythms. This makes Pinealon a peptide of interest in chronobiology and stress-induced sleep dysregulation studies. - Antioxidant and Anti-Inflammatory Effects:
Studies have demonstrated Pinealon’s capacity to reduce oxidative stress markers and modulate inflammatory cytokine expression. By enhancing endogenous antioxidant enzyme activity, such as superoxide dismutase and catalase, the peptide protects cellular structures from free-radical damage. This dual antioxidant and anti-inflammatory profile is relevant to research on chronic stress and inflammation-driven pathologies. - Stress Resistance Enhancement:
Pinealon has been observed to increase stress tolerance in experimental animals exposed to physical and psychological stressors. Research suggests modulation of the hypothalamic-pituitary-adrenal axis and improved adaptive responses at the cellular level. These findings support its inclusion in studies focused on adaptogenic mechanisms and resilience under environmental challenges. - Gene Expression Regulation:
A defining feature of Pinealon is its ability to penetrate cell nuclei and interact with DNA regulatory regions. Research indicates the peptide modulates transcription of genes involved in neurogenesis, apoptosis, and antioxidant defense. This epigenetic activity underpins many of its observed effects and makes Pinealon a valuable tool in molecular biology research on peptide-DNA interactions. - Visual Function and Retinal Support:
Preclinical research has explored Pinealon’s effects on retinal cells and visual function, particularly under ischemic and degenerative conditions. Observations include preservation of photoreceptor integrity and improved electroretinographic responses in stressed models. This positions Pinealon as a candidate of interest in ophthalmological research on age-related retinal decline.
Research Data
| Study / Model | Reported effect |
|---|---|
| Aged rat cognitive performance | ↑ memory retention and learning capacity in Morris water maze tasks |
| Cultured cortical neurons (in vitro) | ↓ oxidative stress markers; ↑ neuronal survival under hypoxic conditions |
| Accelerated aging mouse model (SAMP1) | Extended lifespan and preserved cognitive function compared to controls |
| Human fibroblast culture | ↑ telomerase activity and ↑ telomere length over multiple passages |
| Rotenone-induced neurotoxicity model | Reduced apoptosis and preserved mitochondrial integrity in dopaminergic neurons |
| Elderly cognitive decline observational study | Improved attention, memory recall, and psycho-emotional state markers |
| Ischemia-reperfusion brain injury (rat) | ↓ infarct volume; ↑ neuroprotective gene expression including Bcl-2 |
| Sleep-deprivation behavioral model | Normalized circadian markers and reduced stress-induced cognitive deficits |
Stack Suggestions
Pinealon is often combined in research with:
- Pinealon + Epitalon → Synergistic pineal-axis modulation supporting circadian regulation and cellular longevity research.
- Pinealon + Cerebrolysin → Complementary neurotrophic and neuroprotective effects in cognitive research models.
- Pinealon + Semax → Enhances neuronal signaling and stress-resilience pathways in CNS studies.
- Pinealon + SS-31 → Combines mitochondrial protection with antioxidant support in neurodegeneration models.
⚠ Stacks are for experimental design only; not safety or efficacy guidance.
Pen Dosage Chart
| Pinealon Pen 20 mg | |
| Volume | 2 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.1 mg |
| Example(s) | 10 clicks = 1 mg |
Dosage & Protocols Variations
Standard Research Protocol
- Dose: 1 – 3 mg
- Duration: 2 – 4 weeks
- Frequency: Daily
- Cycle Interval: 4 – 8 weeks off before repeating
- Goal / Description: Baseline protocol for neuroprotection and cognitive support models.
Therapeutic Research Protocol
- Dose: 3 – 5 mg
- Duration: 3 – 4 weeks
- Frequency: Daily
- Cycle Interval: 8 – 12 weeks off before repeating
- Goal / Description: Higher-dose regimen used in studies targeting age-related cognitive decline and oxidative stress.
Biohacker Protocol (experimental)
- Dose: 0.5 – 1 mg
- Duration: 6 – 8 weeks
- Frequency: 5× per week
- Cycle Interval: 4 weeks off before repeating
- Goal / Description: Low-dose continuous exposure for longevity and cellular preservation research.
Possible Side Effects
Pinealon is generally well-tolerated in animal studies and limited human observational research.
Reported side effects are infrequent and mild:
- Transient mild headache during initial dosing.
- Localized irritation or redness at injection site.
- Occasional drowsiness or altered sleep patterns.
- Mild gastrointestinal discomfort in sensitive subjects.
No evidence of hormonal, hepatic, or neurotoxic adverse effects has been observed in available preclinical data. As a short tripeptide, Pinealon is rapidly metabolized into its constituent amino acids, which contributes to its favorable tolerability profile in experimental models.
Product Attributes
- CAS #: 868840-93-5
- Molecular Formula: C15H26N6O8
- Sequence (AA): EDR
- Molecular Weight: 418.4 g/mol
- PubChem CID: 71587241
- Half-Life: ~2-4 hours
- Synonyms: Glu-Asp-Arg, EDR tripeptide, Pineal bioregulator
- Type: Synthetic research tripeptide (cell-penetrating bioregulator)
- Research Focus: Cognition & Neuroprotection, Longevity & Cellular Health
Scientific References
- Short peptides stimulate cell regeneration in skin during aging Animal | In vitro
- Peptide regulation of cell differentiation Animal | In vitro
- Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging Animal | In vitro
- Tripeptides restore the number of neuronal spines under conditions of in vitro modeled Alzheimer’s disease In vitro
- Pinealon enhances resistance of cells of cerebral cortex of rat embryos to oxidative stress Animal | In vitro
- Peptidergic regulation of cell proliferation and renewal during aging Observational | Animal
- Neuroprotective effects of peptide bioregulators in experimental models of neurodegeneration Animal | In vitro
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.
For this reason, we accept mainly Bank Transfers.
We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.
Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.
This method ensures compliance, security, and continuity of service for all customers across the EU.
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