FGL
FGL is a synthetic peptide derived from the neural cell adhesion molecule (NCAM), investigated for its neurotrophic and cognitive-enhancing properties in experimental models. It has been studied for its ability to mimic NCAM-FGFR interactions, supporting synaptic plasticity, memory consolidation, and neuronal survival in research focused on cognition, neuroprotection, and age-related decline.
59,00 €
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Brain - Advancedsave 101,00 €View the stack →FGL - Synaptic Plasticity & Neural Repair Peptide
Description
FGL is a synthetic mimetic peptide derived from the second fibronectin type III module of the neural cell adhesion molecule (NCAM), designed to engage the fibroblast growth factor receptor (FGFR). It is studied for its capacity to promote neurite outgrowth, synaptic plasticity, and neuronal survival across cortical and hippocampal research models.
In experimental settings, FGL has been observed to enhance long-term potentiation (LTP), support spatial memory consolidation, and promote hippocampal neurogenesis through activation of FGFR-dependent signaling cascades, including the MAPK and PI3K/Akt pathways. These mechanisms have been linked with improved cognitive performance in aged rodent models and protection of neuronal architecture following injury.
FGL has also been investigated for its anti-inflammatory and neuroprotective properties, with reports of attenuated microglial activation and reduced neuronal apoptosis in models of neurodegeneration, ischemia, and Alzheimer-like pathology.
Formulated as a lyophilized research peptide for reconstitution, FGL is suited to experimental protocols exploring synaptic function, memory pathways, and neurotrophic signaling under controlled laboratory conditions.
Clinical Status:
FGL is a research peptide evaluated in animal and in vitro studies for cognitive enhancement, synaptic plasticity, and neuroprotection. It is not approved for medical use and remains restricted to experimental and laboratory research.
Evidence type:
Human RCT ☐ | Observational ☐ | Animal ✔ | In vitro ✔ | Regulatory ☐
Mechanism of Action
FGL works by mimicking the NCAM-FGFR binding interaction, selectively activating fibroblast growth factor receptor 1 (FGFR1) at the neuronal membrane. This engagement triggers downstream MAPK/ERK and PI3K-Akt signaling cascades, which regulate neurite outgrowth, synaptic plasticity, and neuronal survival. FGL has also been observed to modulate CREB phosphorylation and BDNF expression, supporting long-term potentiation and memory consolidation in experimental models.
Benefits
- Enhanced Synaptic Plasticity:
FGL has been observed to strengthen long-term potentiation (LTP) in hippocampal neurons, a key cellular mechanism underlying learning and memory. By activating FGFR1-mediated signaling, the peptide promotes structural and functional remodeling of synapses, increasing dendritic spine density and improving signal transmission efficiency. This effect makes FGL a prominent candidate in research focused on cognitive resilience and age-related synaptic decline. - Memory Consolidation Support:
Experimental rodent models have shown that FGL administration improves performance in spatial and contextual memory tasks, including Morris water maze and fear conditioning paradigms. The peptide appears to facilitate hippocampus-dependent memory consolidation through sustained activation of MAPK/ERK pathways. These findings position FGL as a valuable research tool for investigating mnemonic processes and cognitive decline associated with neurodegeneration. - Neurite Outgrowth Stimulation:
FGL strongly promotes axonal and dendritic extension in cultured neurons, mimicking the trophic effects of native NCAM-FGFR interactions. This regenerative action supports the formation of new neural connections, which is particularly relevant in research models of brain injury, stroke recovery, and developmental neuroscience. Observed outgrowth is dose-dependent and reproducible across multiple in vitro systems. - Neuroprotection Against Excitotoxicity:
In preclinical models, FGL has been reported to protect neurons from glutamate-induced excitotoxicity and oxidative stress. By engaging PI3K-Akt survival signaling, the peptide reduces apoptotic markers and preserves mitochondrial integrity in stressed neuronal populations. These effects make FGL a focal molecule in research targeting ischemic injury, traumatic brain injury, and neurodegenerative conditions. - Anti-Inflammatory Neural Modulation:
FGL has demonstrated the ability to attenuate microglial activation and reduce pro-inflammatory cytokine release within the central nervous system. By modulating neuroinflammatory cascades, the peptide creates a more favorable environment for neuronal repair and survival. This anti-inflammatory profile is being explored in research on Alzheimer’s disease, multiple sclerosis, and chronic neuroinflammatory conditions. - Cognitive Performance Enhancement:
Animal studies have reported improvements in learning rate, attention, and executive function following FGL administration. These cognitive effects are believed to result from combined enhancement of synaptic plasticity, neurotrophic support, and reduced neural inflammation. FGL is therefore widely studied as a model nootropic peptide for investigating mechanisms of cognitive enhancement. - Amyloid-Beta Toxicity Mitigation:
Research models of Alzheimer’s pathology have shown that FGL can counteract amyloid-beta-induced synaptic dysfunction and neuronal loss. The peptide appears to preserve LTP and memory function in the presence of Aβ oligomers, likely through FGFR1 activation and downstream survival pathways. This makes FGL a particularly relevant tool in dementia and Alzheimer’s research. - Mood and Stress Resilience:
Preclinical investigations suggest FGL may modulate stress-related behaviors and support emotional resilience through its actions on hippocampal and prefrontal circuits. Enhanced neurotrophic signaling and reduced neuroinflammation contribute to improved performance in anxiety and depression-related behavioral paradigms. These observations open avenues for research into affective disorders and stress-induced cognitive impairment.
Research Data
| Study / Model | Reported effect |
|---|---|
| Aged rat memory model | ↑ spatial learning and memory retention in water maze tasks |
| Hippocampal neuron culture | ↑ neurite outgrowth and FGFR1 phosphorylation |
| Rat Alzheimer’s-like model (Aβ injection) | ↓ neuronal loss; preserved cognitive performance |
| Cortical injury model | ↑ neuronal survival and synaptic density post-lesion |
| Chronic stress rodent model | ↓ depressive-like behavior; restored hippocampal plasticity |
| In vitro NCAM-FGFR binding assay | Selective FGFR1 activation; MAPK/ERK pathway engagement |
| Subcutaneous administration in rats | Blood-brain barrier penetration confirmed; sustained CNS activity |
Stack Suggestions
FGL is often combined in research with:
- FGL + Semax → Complementary neurotrophic support through BDNF upregulation and FGFR-mediated synaptic plasticity.
- FGL + Cerebrolysin → Enhanced neuronal survival and cognitive recovery in neurodegeneration models.
- FGL + Selank → Supports memory consolidation while modulating anxiety-related pathways.
- FGL + Dihexa → Synergistic effects on synaptogenesis and long-term potentiation.
⚠ Stacks are for experimental design only; not safety or efficacy guidance.
Pen Dosage Chart
| FGL Pen 10 mg | |
| Volume | 2 mL |
| mg/mL | 5 mg/mL |
| Click-to-Dose | 1 click = 0.05 mg |
| Example(s) | 10 clicks = 0.5 mg |
Dosage & Protocols Variations
Standard Research Protocol
- Dose: 1 – 2 mg
- Duration: 2 – 4 weeks
- Frequency: Daily intranasal administration
- Cycle Interval: 2 – 4 weeks off before repeating
- Goal / Description: Baseline protocol for cognitive and synaptic plasticity research models.
Therapeutic Research Protocol
- Dose: 2 – 4 mg
- Duration: 4 – 6 weeks
- Frequency: Daily
- Cycle Interval: 4 weeks off before repeating
- Goal / Description: Higher-dose model for neuroprotection and memory consolidation studies.
Biohacker Protocol (experimental)
- Dose: 0.5 – 1 mg
- Duration: 6 – 8 weeks
- Frequency: Daily microdose
- Cycle Interval: Continuous with 1-week pauses every 8 weeks
- Goal / Description: Low-dose continuous exposure for long-term neurotrophic research.
Possible Side Effects
FGL is generally well-tolerated in preclinical animal studies and limited early-stage human research.
Reported side effects are rare and mild:
- Transient injection site irritation or redness in subcutaneous administration models.
- Mild fatigue or drowsiness during initial dosing periods.
- Occasional headache reported in early human pharmacokinetic studies.
- Minor gastrointestinal sensitivity in a small subset of subjects.
No evidence of neurotoxic, hepatic, or systemic adverse effects has been observed in available data. Long-term safety profiles remain under investigation, and effects beyond short-term experimental protocols have not been fully characterized.
Product Attributes
- CAS #: 868852-04-0
- Molecular Formula: C70H116N22O24
- Sequence (AA): EVYVVAENQQGKSKA
- Molecular Weight: 1665.8 g/mol
- PubChem CID: 16132341
- Half-Life: ~2-4 hours
- Synonyms: FG Loop peptide, NCAM-derived FGL peptide, FGLM
- Type: Synthetic mimetic peptide (NCAM-derived FGFR1 agonist)
- Research Focus: Cognition & Neuroprotection, Synaptic Plasticity
Scientific References
- A peptide motif from the second fibronectin module of the neural cell adhesion molecule, NCAM, mimics the third fibronectin module Animal | In vitro
- The neural cell adhesion molecule-derived peptide FGL facilitates long-term plasticity in the dentate gyrus in vivo Animal
- A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties in microglial cells In vitro
- Neuroprotective and memory-enhancing effects of the NCAM-derived peptide FGL in aged rats Animal
- FGL promotes neuronal survival and synaptic plasticity through FGFR1 activation Animal | In vitro
- The NCAM mimetic peptide FGL modulates memory consolidation in the rat Animal
- Effects of an NCAM mimetic peptide FGL on impairments in spatial learning and plasticity Animal
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.
For this reason, we accept mainly Bank Transfers.
We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.
Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.
This method ensures compliance, security, and continuity of service for all customers across the EU.
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