Cortagen
Cortagen is a synthetic short-chain peptide bioregulator composed of four amino acids (Ala-Glu-Asp-Pro), developed within the field of cytomedine research for its targeted action on nervous tissue. It is investigated for its potential to modulate neuronal regeneration, cognitive function, and neuroprotective pathways in experimental models of aging and neural injury.
59,00 €
📦Available in 3 stacks · save up to 101,00 €
Brain - Advancedsave 101,00 €View the stack →Sleep - Advancedsave 98,00 €View the stack →Bioregulator - Advancedsave 86,00 €View the stack →Cortagen - Brain & Cortex Bioregulator Peptide
Description
Cortagen is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Pro, belonging to the family of short peptide bioregulators developed from research on cortical brain extracts. It is studied for its capacity to modulate gene expression in nervous tissue and to support neuronal regeneration, cognitive function, and cerebrovascular integrity in experimental models.
In preclinical research, Cortagen has been observed to stimulate neurogenesis, enhance synaptic plasticity, and promote the regeneration of peripheral and central nervous system tissue following injury. Investigations point to its ability to regulate the transcription of genes involved in neurotrophic factor expression, antioxidant defense, and neuronal differentiation, contributing to its broad neuroprotective profile.
Additional studies have examined Cortagen’s role in modulating oxidative stress and reducing markers of neuroinflammation in aged and lesioned brain models, supporting interest in its application within research on cognitive decline and neurodegenerative processes.
Supplied as a lyophilized powder in research vials, Cortagen requires reconstitution with bacteriostatic water and is typically administered subcutaneously in experimental protocols, allowing precise dosing control in laboratory conditions.
Clinical Status:
Cortagen is a research peptide bioregulator evaluated primarily in animal models and limited observational studies focused on neuroregeneration, cognitive performance, and cerebrovascular function. It is not approved for medical use and remains restricted to experimental and laboratory research.
Evidence type:
Human RCT ☐ | Observational ✔ | Animal ✔ | In vitro ✔ | Regulatory ☐
Mechanism of Action
Cortagen exerts its effects by modulating gene expression in neural and connective tissues, functioning as a short peptide bioregulator capable of penetrating cell and nuclear membranes. Once inside the nucleus, it has been observed to interact with DNA promoter regions, influencing the transcription of genes involved in neuronal differentiation, collagen synthesis, and neurotrophic factor expression. This regulatory action is studied for its capacity to restore peptide balance in aged or stressed tissues, supporting neuroregeneration and cortical function in experimental models.
Benefits
- Cerebrovascular Recovery Support:
Cortagen has been investigated in experimental models of ischemic and post-stroke brain injury, where it appears to support neurological recovery and reduce functional deficits. Research suggests modulation of neurotrophic signaling and improved cerebral blood flow parameters. This effect has positioned Cortagen as a focal point in studies on neuroprotection and cerebrovascular rehabilitation. - Neuronal Regeneration and Plasticity:
Studies have observed that Cortagen promotes neuronal survival and supports synaptic plasticity in models of nervous system injury. It is reported to upregulate expression of neurotrophic factors such as BDNF and NGF, which are central to neuron repair and dendritic remodeling. This makes Cortagen a key candidate in research on neurodegenerative conditions and central nervous system regeneration. - Cognitive Function Modulation:
Cortagen has been evaluated for its effects on learning, memory consolidation, and attention in preclinical models. Research suggests improved performance on memory-based behavioral tasks and enhanced electrical activity in cortical regions associated with cognition. These findings position Cortagen within investigations of cognitive aging, mental fatigue, and post-injury cognitive recovery. - Peripheral Nerve Repair:
In peripheral nerve injury models, Cortagen has been reported to accelerate axonal regrowth and improve conduction velocity. Observed effects include enhanced Schwann cell activity and restoration of myelin sheath integrity. This places Cortagen within ongoing research on peripheral neuropathies, post-surgical nerve recovery, and traumatic nerve damage. - Neuroinflammation Reduction:
Cortagen has been observed to modulate inflammatory signaling within nervous tissue, reducing markers such as TNF-α and pro-inflammatory cytokines in experimental models. This anti-inflammatory profile is studied as a mechanism behind its neuroprotective properties. Researchers consider this pathway relevant to chronic neuroinflammatory conditions and oxidative stress models. - Antioxidant Activity in Neural Tissue:
Research models indicate that Cortagen supports endogenous antioxidant defenses within brain and nerve tissue, helping to limit oxidative damage caused by free radicals. Reported effects include increased superoxide dismutase (SOD) and glutathione peroxidase activity. This contributes to the peptide’s role in studies focused on cellular longevity and neural resilience. - Sleep and Autonomic Regulation:
Cortagen has been investigated for its influence on sleep architecture and autonomic nervous system balance. Studies report normalization of sleep-wake cycles and improved electroencephalographic patterns in models of disrupted neural function. This area of research is relevant to investigations of stress, circadian misalignment, and age-related sleep changes. - Gene Expression and Bioregulatory Action:
As a short peptide bioregulator, Cortagen is studied for its ability to penetrate cellular and nuclear membranes and interact directly with DNA promoter regions. Research suggests selective regulation of gene expression in neural tissues, supporting protein synthesis tied to neuronal function. This places Cortagen within the broader Khavinson peptide framework of tissue-specific epigenetic modulation.
Research Data
| Study / Model | Reported effect |
|---|---|
| Aged rat cortical neuron cultures | ↑ neurite outgrowth and ↑ expression of neurotrophic markers |
| Rodent traumatic brain injury models | Accelerated recovery of motor and cognitive function; ↓ neuroinflammatory markers |
| Aged rats (chronic administration) | ↑ learning and memory performance in maze-based tasks |
| In vitro fibroblast cultures | Normalization of gene expression patterns associated with cellular aging |
| Geriatric human observational studies | Reported improvements in cognitive performance, sleep quality, and mood in elderly subjects |
| Post-stroke rehabilitation observational research | ↑ recovery of higher cortical functions and ↓ asthenic symptoms |
| Cellular oxidative stress models | ↓ lipid peroxidation and ↑ endogenous antioxidant enzyme activity |
Stack Suggestions
Cortagen is often combined in research with:
- Cortagen + Pinealon → Synergistic neuroprotective and cognitive support through complementary peptide bioregulation.
- Cortagen + Epitalon → Combines neural regeneration with telomerase activation for longevity-focused research models.
- Cortagen + Selank → Supports cognitive resilience and stress adaptation via complementary neuropeptide pathways.
- Cortagen + Semax → Enhances neurotrophic signaling and BDNF expression in neuroregenerative studies.
⚠ Stacks are for experimental design only; not safety or efficacy guidance.
Pen Dosage Chart
| Cortagen Pen 20 mg | |
| Volume | 2 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.1 mg |
| Example(s) | 10 clicks = 1 mg |
Dosage & Protocols Variations
Standard Research Protocol
- Dose: 1 – 2 mg
- Duration: 10 – 20 days
- Frequency: Daily
- Cycle Interval: 4 – 6 months off before repeating
- Goal / Description: Baseline protocol for connective tissue and joint research models.
Therapeutic Research Protocol
- Dose: 2 – 4 mg
- Duration: 15 – 30 days
- Frequency: Daily
- Cycle Interval: 3 – 6 months off before repeating
- Goal / Description: Higher-dose protocol used in cartilage repair and post-injury recovery studies.
Biohacker Protocol (experimental)
- Dose: 0.5 – 1 mg
- Duration: 20 – 30 days
- Frequency: 3 – 4× per week
- Cycle Interval: 2 – 3 months off before repeating
- Goal / Description: Microdose continuous exploration for long-term connective tissue maintenance.
Possible Side Effects
Cortagen is generally well-tolerated in preclinical and limited human observational studies.
Reported side effects are rare and mild:
- Localized redness or transient discomfort at the injection site.
- Mild drowsiness or fatigue during initial dosing.
- Occasional headache or lightheadedness in sensitive subjects.
- Transient changes in sleep patterns reported in early research models.
No evidence of hormonal, hepatic, or systemic adverse effects has been observed in available data.
Product Attributes
- CAS #: 196604-48-5
- Molecular Formula: C17H26N4O9
- Sequence (AA): AEDP
- Molecular Weight: 430.41 g/mol
- PubChem CID: N/A (peptide bioregulator)
- Half-Life: ~20-30 minutes (rapid tissue uptake)
- Synonyms: Ala-Glu-Asp-Pro, AEDP, Cortexin-related tetrapeptide, Khavinson peptide
- Type: Synthetic short-chain peptide bioregulator (cytomedine)
- Research Focus: Cognition & Neuroprotection, Recovery & Performance
Scientific References
- Effect of the peptide Cortagen on regeneration of the sciatic nerve Animal
- Cortagen regulation of gene expression in the cerebral cortex Animal | In vitro
- Peptidergic regulation of gene expression in cortical neurons In vitro
- Short peptides as biological regulators of cellular activity Observational | In vitro
- Khavinson peptides: their role in the regulation of gene expression and protein synthesis Animal | In vitro
- Peptide regulation of cell differentiation, proliferation, and apoptosis In vitro
- Geroprotective effects of short peptides in experimental models Animal
- Epigenetic mechanisms of peptide-mediated neuroprotection Animal | In vitro
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.
For this reason, we accept mainly Bank Transfers.
We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.
Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.
This method ensures compliance, security, and continuity of service for all customers across the EU.
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