Chonluten
Chonluten is a short synthetic peptide bioregulator derived from bronchial epithelial tissue, studied for its targeted action on the respiratory system. It has been investigated for its ability to support lung epithelial regeneration, modulate bronchial inflammation, and restore mucosal function. Used in research models focused on pulmonary recovery, cellular protection, and respiratory resilience.
59,00 €
Quality Certificates
Independent third-party lab analysis (CoA) - from our own in-house brand.
Chonluten - Lung & Respiratory Bioregulator Peptide
Description
Chonluten is a short tripeptide bioregulator composed of the amino acid sequence Glu-Asp-Gly (EDG), originally isolated from bronchial epithelial cells. It belongs to the family of Khavinson peptides, designed to selectively interact with respiratory tissue and regulate gene expression involved in epithelial maintenance and repair.
In experimental models, Chonluten has been observed to stimulate regeneration of bronchial epithelium, enhance mucociliary clearance, and modulate local immune responses within lung tissue. Reported mechanisms include normalization of surfactant production, reduction of oxidative damage in alveolar cells, and downregulation of pro-inflammatory cytokines associated with chronic bronchial conditions.
Additional research has explored Chonluten’s role in protecting against age-related decline of respiratory function, with observations of improved epithelial barrier integrity and reduced fibrotic markers in aged tissue models. Its low molecular weight and tissue-specific affinity make it a focus of geroprotective and pulmonary research.
Formulated as a lyophilized powder for reconstitution, Chonluten is suitable for subcutaneous administration in controlled laboratory protocols targeting respiratory and epithelial research.
Clinical Status:
Chonluten is a research peptide bioregulator studied primarily in Russian preclinical and limited observational research focused on respiratory regeneration and geroprotection. It is not approved for medical use and remains restricted to experimental and laboratory research.
Evidence type:
Human RCT ☐ | Observational ✔ | Animal ✔ | In vitro ✔ | Regulatory ☐
Mechanism of Action
Chonluten works by penetrating cellular and nuclear membranes of bronchial epithelial cells, where it binds directly to specific regions of DNA and modulates gene expression involved in tissue regeneration and immune balance. This tripeptide has been observed to stimulate epithelial cell proliferation, restore ciliary function, and downregulate pro-inflammatory cytokines such as TNF-α and IL-6, supporting mucosal repair and bronchial homeostasis in experimental respiratory models.
Benefits
- Bronchial Epithelial Regeneration:
Chonluten has been studied for its ability to stimulate the renewal of bronchial epithelial cells, supporting the structural integrity of the respiratory mucosa. Experimental models have observed enhanced ciliated cell recovery and improved tissue architecture following exposure to inflammatory or toxic stimuli. This regenerative action is considered central to its application in research focused on chronic bronchopulmonary conditions and post-injury epithelial repair. - Modulation of Bronchial Inflammation:
Research has reported that Chonluten reduces the expression of pro-inflammatory cytokines within respiratory tissue, particularly in models of chronic obstructive pulmonary disease (COPD) and chronic bronchitis. By modulating local immune signaling, this peptide appears to attenuate excessive inflammatory responses while preserving normal mucosal defense. This effect makes it a relevant candidate in research targeting persistent airway inflammation. - Restoration of Mucociliary Function:
Chonluten has been observed to support the restoration of mucociliary clearance, a key defense mechanism of the airways. Experimental studies suggest improved cilia activity and balanced mucus secretion, contributing to more efficient clearance of pathogens and particulates. This property is of interest in research on chronic respiratory dysfunction where mucociliary impairment plays a central role. - Support for Alveolar Integrity:
Investigations have reported that Chonluten contributes to the preservation of alveolar structure and function in models of pulmonary stress. By promoting epithelial stability and reducing oxidative damage, it has been linked to improved gas-exchange parameters in preclinical studies. This positions Chonluten as a peptide of interest in research on emphysema-like pathology and age-related pulmonary decline. - Antioxidant Activity in Respiratory Tissue:
Chonluten has demonstrated antioxidant properties in experimental settings, helping to reduce oxidative stress markers within bronchial and alveolar cells. By modulating reactive oxygen species and supporting endogenous defense pathways, the peptide has been studied for its role in protecting respiratory tissue from environmental damage, including smoke and pollutant exposure in animal models. - Gene Expression Regulation:
As a Khavinson bioregulator, Chonluten is studied for its ability to interact directly with DNA and modulate the expression of genes involved in epithelial differentiation, proliferation, and immune regulation. This selective transcriptional influence is a defining feature of short peptide bioregulators and underpins much of the research interest in tissue-specific regenerative effects observed in respiratory models. - Improved Functional Respiratory Parameters:
Preclinical and limited observational research has reported improvements in functional respiratory indicators following Chonluten administration, including better ventilation efficiency and reduced symptom burden in chronic bronchopulmonary models. These observations have positioned the peptide as a candidate in research focused on restoring respiratory performance compromised by chronic disease or aging. - Potential Role in Geroprotective Research:
Chonluten has been examined within the broader framework of Khavinson peptide research on geroprotection, where short bioregulators are studied for their capacity to delay age-related tissue decline. In the respiratory context, this includes investigations into reducing senescence markers in bronchial epithelium and supporting long-term pulmonary resilience in aging animal models.
Research Data
| Study / Model | Reported effect |
|---|---|
| Aged rat bronchial epithelium | ↑ epithelial cell proliferation, restored mucociliary structure |
| Chronic bronchitis animal model | ↓ inflammatory infiltration, improved bronchial mucosal integrity |
| In vitro bronchial cell culture | ↑ expression of regeneration-associated genes, enhanced cellular differentiation |
| Cigarette smoke exposure model | ↓ oxidative damage in lung tissue, preserved epithelial barrier function |
| Elderly human observational study | Improved respiratory function markers and reduced bronchopulmonary symptoms |
| COPD-like experimental model | ↓ pro-inflammatory cytokines, improved alveolar architecture |
Stack Suggestions
Chonluten is often combined in research with:
- Chonluten + Epithalon → Supports telomere maintenance alongside bronchial epithelial regeneration in longevity models.
- Chonluten + Thymalin → Enhances mucosal immune modulation and respiratory defense pathways.
- Chonluten + KPV → Combines anti-inflammatory action with epithelial repair in airway research.
- Chonluten + Vesugen → Supports vascular integrity and oxygen exchange in pulmonary tissue models.
⚠ Stacks are for experimental design only; not safety or efficacy guidance.
Pen Dosage Chart
| Chonluten Pen 20 mg | |
| Volume | 2 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.1 mg |
| Example(s) | 10 clicks = 1 mg |
Dosage & Protocols Variations
Standard Research Protocol
- Dose: 1 – 2 mg
- Duration: 2 – 3 weeks
- Frequency: Daily, oral or sublingual
- Cycle Interval: 3 – 6 months before repeating
- Goal / Description: Baseline protocol for bronchial epithelial regeneration models.
Therapeutic Research Protocol
- Dose: 2 – 3 mg
- Duration: 3 – 4 weeks
- Frequency: Daily, divided into morning and evening doses
- Cycle Interval: 2 – 3 months before repeating
- Goal / Description: Used in models targeting chronic bronchial inflammation and mucosal recovery.
Biohacker Protocol (experimental)
- Dose: 0.5 – 1 mg
- Duration: 4 – 6 weeks
- Frequency: Daily, low-dose continuous
- Cycle Interval: 1 – 2 months off before repeating
- Goal / Description: Microdosing approach for long-term respiratory resilience research.
Possible Side Effects
Chonluten is generally well-tolerated in preclinical and limited human observational studies.
Reported side effects are rare and mild:
- Mild transient fatigue during initial dosing.
- Localized irritation or redness at injection site.
- Occasional mild headache reported in sensitive subjects.
- Transient nasal or throat dryness when administered intranasally.
No evidence of hormonal, hepatic, or systemic adverse effects has been observed in available data.
Product Attributes
- CAS #: N/A (peptide bioregulator, no assigned CAS)
- Molecular Formula: C11H18N4O8
- Sequence (AA): EDG
- Molecular Weight: 334.3 g/mol
- PubChem CID: N/A
- Half-Life: ~20-40 minutes
- Synonyms: Glu-Asp-Gly, EDG tripeptide, Khavinson bronchial peptide, Bronchogen analog
- Type: Synthetic short peptide bioregulator (Khavinson family)
- Research Focus: Respiratory Health, Epithelial Regeneration, Immunity & Inflammation
Scientific References
- Peptidergic regulation of expression of genes encoding antioxidant and proapoptotic proteins in bronchial epithelium Animal | In vitro
- Khavinson peptides regulate gene expression and protein synthesis: cellular and molecular mechanisms In vitro
- Short Peptides and Telomere Length Regulator Hormone Irisin Animal | In vitro
- Peptide regulation of cell differentiation In vitro
- Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation and renewal In vitro
- Short Peptides as Tools for Cellular Function Regulation Observational | In vitro
- Effects of peptide bioregulators on bronchopulmonary system function Animal | Observational
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.
For this reason, we accept mainly Bank Transfers.
We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.
Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.
This method ensures compliance, security, and continuity of service for all customers across the EU.
Didn't find the answer to your question?
View all frequently asked questionsRELATED PRODUCTS
