Vilon
Vilon is a synthetic dipeptide bioregulator (Lys-Glu) developed within the Khavinson family of short peptides and studied for its immunomodulatory and geroprotective properties. In experimental models, it has been investigated for its ability to influence thymic function, gene expression, and cellular aging markers, making it a focus of research in immunology and aging biology.
59,00 €
Vilon - Immunomodulatory & Geroprotective Dipeptide Bioregulator
Investigated for normalization of CD4+/CD8+ ratios and lymphocyte proliferative responses in aged rodent models
Studied for enhanced thymocyte differentiation, increased precursor counts, and improved cortical-medullary thymic organization
Explored for site-specific DNA binding at promoter regions influencing cell cycle and apoptosis transcription
Examined for reductions in TNF-alpha and IL-6 signaling in aged rodent inflammatory models
Investigated for its influence on IL-2 transcription and related lymphocyte cytokine signaling pathways
Reported to reduce lipid peroxidation and enhance superoxide dismutase and catalase activity in aged tissues
Studied for improved mitochondrial activity and broader cytoprotective effects observed in rodent tissue models
Evaluated in bone marrow suppression models for restoration of blood cell populations and stem cell compartments
Description
Vilon is a synthetic dipeptide bioregulator composed of L-lysine and L-glutamic acid (Lys-Glu, KE), developed within the Khavinson peptide research program. With a molecular weight of ~275.3 g/mol and a short two-amino-acid sequence, it belongs to the family of short regulatory peptides investigated for their ability to modulate gene expression and cellular function in aging and immune research models.
In experimental studies, Vilon has been observed to modulate thymus-dependent immunity, support thymocyte and T-lymphocyte differentiation, and influence interleukin-2 (IL-2) expression in aged rodent models. Research reports also describe effects on chromatin structure and the transcription of genes associated with immune regulation and cellular senescence.
Additional preclinical work has evaluated this bioregulator within a gerontology research context, including observations of reduced age-related tissue changes, altered cytokine profiles, and modulation of oxidative stress markers in rodent and cell culture systems.
Supplied as a ready-to-use injection pen (2 mL solution, 1 click = 0.01 mL) with >98% HPLC purity, Vilon is intended for subcutaneous research administration under controlled laboratory conditions.
Clinical Status:
Vilon is a research peptide bioregulator studied primarily in Russian and Eastern European preclinical and limited observational investigations focused on immunomodulation and aging biology. It is not approved for medical use and remains restricted to experimental and laboratory research.
Evidence type:
Human RCT ☐ | Observational ✔ | Animal ✔ | In vitro ✔ | Regulatory ☐
Mechanism of Action
Vilon is a short dipeptide (Lys-Glu) that appears to act as a bioregulator by penetrating cellular and nuclear membranes and interacting directly with DNA and histone proteins. Research models suggest it modulates gene expression through site-specific binding to promoter regions, influencing transcription of genes involved in immune regulation, cell proliferation, and apoptosis. Vilon has also been reported to restore thymic function and normalize T-cell differentiation in aged or immunosuppressed experimental systems.
Benefits
- Immunomodulatory Activity:
Vilon has been investigated extensively for its ability to modulate T-cell populations and restore immune competence in aging rodent models. Research has reported normalization of CD4+/CD8+ ratios, enhanced thymic function, and increased proliferative response of lymphocytes in animals with age-related immune decline. These observations position Vilon as a central dipeptide in the Khavinson line of bioregulators studied for immune restoration. - Geroprotective Research Context:
In long-term rodent studies, Vilon has been investigated for its influence on biomarkers of biological aging and the onset of age-associated changes. Researchers have reported reductions in chronic inflammation markers and preserved organ function in experimental models. These geroprotective observations are a primary focus of ongoing gerontology research into short-chain peptide bioregulators. - Gene Expression Regulation:
Vilon is studied for its proposed mechanism of site-specific DNA binding, where the KE dipeptide interacts with gene promoter regions to influence transcription. Experimental models have reported altered expression of genes involved in cell cycle regulation, apoptosis, and immune signaling, offering a molecular rationale for its systemic effects observed at remarkably low concentrations. - Thymic Function and Thymocyte Differentiation:
Research models of thymic involution have documented Vilon’s capacity to restore thymic structure and promote repopulation of T-lymphocyte precursors. Investigators have observed increased thymocyte counts, enhanced thymocyte differentiation, improved cortical-medullary organization, and increased output of mature T-cells. These findings support its investigation as a tool for studying age-related thymic decline and immunosenescence. - Antioxidant and Cellular Protection:
Vilon has been evaluated for its influence on oxidative stress markers in aged tissues. Studies have reported reduced lipid peroxidation, enhanced activity of endogenous antioxidant enzymes such as superoxide dismutase and catalase, and improved mitochondrial function in rodent models. These effects contribute to its broader cytoprotective profile under experimental conditions. - Hematopoietic and Bone Marrow Modulation:
Experimental research has investigated Vilon for its influence on bone marrow activity and hematopoietic recovery. In models of radiation-induced or chemically induced suppression, Vilon has been observed to support restoration of blood cell populations and preserve stem cell compartments, suggesting a regulatory role in the hematopoietic microenvironment. - Anti-Inflammatory Modulation:
Vilon has been studied for its ability to regulate pro-inflammatory cytokine profiles, including reductions in TNF-α and IL-6 in aged or immunocompromised rodent models. By rebalancing systemic inflammatory signaling, Vilon is explored in research contexts related to inflammaging, the chronic low-grade inflammation associated with biological aging. - IL-2 and Cytokine Expression:
Vilon has been investigated for its influence on IL-2 expression and related cytokine signaling in lymphocyte cultures and rodent models. Researchers have hypothesized that modulated gene expression, chromatin-level effects, and enhanced lymphocyte signaling contribute to the observed immunomodulatory profile, making Vilon of interest in gerontology-oriented bioregulator research.
Research Data
| Study / Model | Reported effect |
|---|---|
| Aged mice, long-term oral administration | ↑ thymocyte differentiation markers and partial restoration of T-cell subset ratios versus controls |
| Thymocyte and splenocyte cultures | ↑ proliferation and restored T-cell responsiveness in immunosuppressed samples |
| Irradiated and cyclophosphamide-treated rodents | Accelerated recovery of leukocyte and lymphocyte counts |
| Aged rat thymus tissue | Partial reversal of age-related thymic involution and ↑ hormone-producing cell density |
| Peripheral blood lymphocyte cultures | Modulation of interleukin (IL-2) expression and normalization of CD4/CD8 ratios in vitro |
| Chromatin and gene expression assays | Site-specific binding to DNA regions regulating immune and senescence-related genes |
| Rodent splenocyte gene expression panels | Altered transcription of IL-2 and related immunoregulatory genes in gerontology research models |
Stack Suggestions
Vilon is often combined in research with:
- Vilon + Epitalon → Explores synergistic geroprotective effects via telomerase activation and immune restoration.
- Vilon + Thymalin → Complementary thymic and immunomodulatory peptide pairing studied in aging models.
- Vilon + Pinealon → Combines immune bioregulation with neuroprotective short-peptide signaling.
- Vilon + Thymosin Alpha-1 → Investigated for broader immune competence and lymphocyte modulation.
⚠ Stacks are for experimental design only; not safety or efficacy guidance.
Pen Dosage Chart
| Vilon Pen 20 mg | |
|---|---|
| Volume | 2 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.1 mg |
| Example(s) | 10 clicks = 1 mg |
Dosage & Protocols Variations
Standard bioregulator course
- Dose: 1 mg (10 clicks)
- Duration: 20 days
- Frequency: Once daily, subcutaneous (SubQ) with the pen
- Cycle Interval: 1-2 courses per year, about 6 months apart
- Pen Coverage: 1 pen = 20 days
- Goal / Description: Bioregulator research on immunomodulatory and gene-expression effects in cell and rodent models. Basis: derived from a published or patent dose range; not a validated human dose.
Intensive short course
- Dose: 2 mg (20 clicks)
- Duration: 10 days
- Frequency: Once daily, subcutaneous (SubQ) with the pen
- Cycle Interval: 1-2 courses per year, about 6 months apart
- Pen Coverage: 1 pen = 10 days
- Goal / Description: Shorter, higher-dose bioregulator course for the same research models. Basis: derived from a published or patent dose range; not a validated human dose.
Bioregulator stack with Thymalin 20 mg
- Dose: 1 mg (10 clicks) + 1 – 2 mg Thymalin (Thymalin Pen 20 mg: 10 – 20 clicks)
- Duration: 10 days
- Frequency: Once daily, subcutaneous (SubQ) with the pen
- Cycle Interval: 1-2 courses per year, about 6 months apart
- Pen Coverage: 1 pen = 20 days
- Goal / Description: Parallel course with the thymus-derived bioregulator from which the KE dipeptide was designed. Basis: vendor/community convention only; no published dosing study.
Possible Side Effects
Vilon is reported to be well-tolerated in preclinical research, with cell culture and rodent studies describing a favorable safety profile at the low microgram-range doses typically used for bioregulator investigations.
- No significant toxicity, mutagenicity, or carcinogenicity has been reported in available animal studies.
- Transient local irritation at the injection site has been noted in some rodent protocols.
- Mild, non-specific changes in immune cell counts have been observed, consistent with its immunomodulatory activity.
- Long-term and large-scale human safety data remain limited and are not formally established.
No evidence of hormonal, hepatic, or systemic adverse effects has been documented in the available preclinical literature. As a research compound, Vilon is restricted to laboratory use and has not been evaluated in regulated clinical safety trials.
Product Attributes
- CAS #: 45234-02-4
- Molecular Formula: C11H21N3O5
- Sequence (AA): KE
- Molecular Weight: ~275.3 g/mol
- PubChem CID: 7010502
- Half-Life: N/A (not established)
- Synonyms: KE, Lys-Glu, L-lysyl-L-glutamic acid, H-Lys-Glu-OH
- Type: Synthetic research peptide (dipeptide bioregulator)
- Research Focus: Khavinson-type dipeptide bioregulator (KE) studied for immunomodulatory and geroprotective effects in cell and rodent models
Scientific References
- Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells In vitro
- Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology Animal
- KE peptide regulates SIRT1, PARP1, PARP2 gene expression and protein synthesis in human mesenchymal stem cells aging In vitro
- Peptide Regulation of Gene Expression: A Systematic Review Review
- PubChem CID 7010502 Registry
- Patent US6642201B1 (Khavinson, Morozov, Malinin, Sery) Patent
- Khavinson VK et al. Molekulyarnaya Meditsina 2021 Peer-reviewed
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™: precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1-8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6-8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.
For this reason, we accept mainly Bank Transfers.
We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.
Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.
This method ensures compliance, security, and continuity of service for all customers across the EU.
Didn't find the answer to your question?
View all frequently asked questions
