Selank
Selank is a synthetic heptapeptide derived from the endogenous tetrapeptide tuftsin, studied for its role in anxiety modulation and cognitive stability. In clinical and preclinical research, it has been observed to influence GABAergic and monoaminergic neurotransmission. Subcutaneous administration supports neurotransmitter balance and stress-response regulation in experimental models. Formulated in a stabilized pre-mixed injection pen for research use only.
66,00 €
Quality Certificates
Independent third-party lab analysis (CoA) - from our own in-house brand.
📦Available in 4 stacks · save up to 101,00 €
Brain - Startsave 31,00 €View the stack →Brain - Advancedsave 101,00 €View the stack →Sleep - Startsave 32,00 €View the stack →Sleep - Advancedsave 98,00 €View the stack →Selank - Anxiolytic Signaling & Neurotransmitter Modulation
Description
Selank is a synthetic analog of the endogenous immunomodulatory peptide tuftsin, modified to enhance stability and central nervous system activity. It belongs to the class of regulatory neuropeptides and is primarily studied in domains such as anxiety research, stress-response biology, and cognitive modulation. Unlike classical benzodiazepine compounds, Selank does not directly bind GABA-A receptors. Instead, research indicates modulation of GABAergic tone and monoamine balance through regulatory signaling pathways.
Our formulation is provided in a stabilized pre-mixed injection pen for SubQ administration. Subcutaneous delivery supports consistent systemic exposure and reliable peptide absorption in research protocols. Each unit is freshly prepared to maintain peptide integrity and standardized dosing. This format eliminates multi-step reconstitution and simplifies laboratory handling. The product is formulated strictly for research use only.
In research models, Selank has been observed to modulate GABA turnover and influence serotonin and dopamine signaling pathways. Gene expression studies demonstrate regulation of inflammatory cytokines and neurotrophic factors under stress conditions. Clinical research in anxiety-related contexts has explored its effects on cognitive performance and emotional stability.
Clinical Status
Human RCT ▣ | Observational ▣ | Animal ✔ | In vitro ✔
Primarily studied in neurobehavioral and anxiolytic research contexts, with limited regional human trials.
Mechanism of Action
Selank modulates GABAergic and monoaminergic signaling pathways rather than acting as a direct receptor agonist. Research indicates normalization of GABA turnover → improved inhibitory neurotransmission balance. Studies also demonstrate modulation of serotonin and dopamine levels in cortical regions. This regulatory action supports emotional stability and cognitive clarity in experimental stress models. Unlike sedative compounds, Selank does not produce pronounced motor suppression in research settings.
Benefits
- Modulation Of GABAergic Signaling:
Selank has been studied for its ability to influence GABA turnover without directly binding to GABA-A receptors. Research indicates normalization of inhibitory neurotransmission in stress-exposed animal models. Unlike benzodiazepines, Selank does not produce strong sedative or motor-impairing effects in experimental settings. Behavioral studies demonstrate reduced anxiety markers with preserved cognitive function. Evidence type: Human clinical studies ✔ | Animal ▣. - Serotonin And Dopamine Regulation:
Preclinical and clinical data suggest modulation of monoamine systems, particularly serotonin and dopamine pathways. Research indicates improved neurotransmitter balance under stress conditions. Laboratory findings demonstrate altered transporter expression and receptor sensitivity. These mechanisms contribute to emotional stability and cognitive clarity research contexts. - Anxiety Model Performance Improvements:
Clinical studies in anxiety-related research populations demonstrate measurable reductions in anxiety scoring scales. Behavioral assessments show improved emotional regulation without cognitive dulling. Comparative studies suggest preservation of attentional performance during administration. - Stress-Response Regulation:
Animal models indicate ↓ stress-induced corticosterone elevation following Selank exposure. Research suggests modulation of hypothalamic-pituitary-adrenal axis signaling. These effects contribute to stabilized physiological stress responses in experimental settings. - Neuroimmune Interaction Modulation:
Gene expression studies demonstrate influence on inflammatory cytokine regulation within neural tissue. Research indicates potential interplay between immune signaling and neural modulation pathways. This dual regulatory profile distinguishes Selank from purely neurotransmitter-targeted compounds. - Cognitive Stability Under Stress Conditions:
Selank has been evaluated in cognitive testing models under acute stress exposure. Research demonstrates preservation of memory recall and executive performance compared to controls. Mechanistic hypotheses involve monoaminergic stabilization and reduced stress hormone signaling. - Non-Sedative Regulatory Profile:
Unlike classical anxiolytic agents, Selank does not produce significant sedation in controlled research models. Motor coordination and reaction time metrics remain largely preserved. This characteristic supports its positioning in cognitive-focused anxiety research. - High Bioavailability Through Subcutaneous Administration:
Provided in a stabilized pre-mixed injection pen for SubQ administration, ensuring consistent systemic exposure in research protocols. Subcutaneous delivery supports reliable absorption and simplified laboratory handling. Each unit is freshly prepared and intended strictly for research use only.
Research Data
| Study / Model | Reported effect |
|---|---|
| Generalized anxiety disorder clinical trials | ↓ anxiety scores comparable to medazepam without sedation or withdrawal |
| Rat elevated plus-maze model | ↓ anxiety-like behavior; ↑ open-arm exploration time |
| Cortical neurotransmitter analysis (rodent) | Normalized GABA turnover; ↑ serotonin and dopamine metabolism |
| BDNF expression studies in hippocampus | ↑ BDNF mRNA expression supporting neuroplasticity |
| Stress-induced immunosuppression models | Restored interferon and cytokine balance; ↑ immune resilience |
| Cognitive performance tasks in healthy volunteers | ↑ attention, memory consolidation, and mental endurance |
| Enkephalin degradation assays | Inhibition of enkephalin breakdown; prolonged endogenous opioid activity |
Stack Suggestions
Selank is often combined in research with:
- Selank + Semax → Complementary neuropeptide modulation supporting cognitive performance and stress resilience.
- Selank + BPC-157 → Pairs anxiolytic neuropeptide activity with systemic regenerative and gut-brain axis support.
- Selank + Cerebrolysin → Combines GABAergic stabilization with neurotrophic factor activity in cognitive research models.
- Selank + NAD+ → Supports neuronal energy metabolism alongside neurotransmitter balance.
⚠ Stacks are for experimental design only; not safety or efficacy guidance.
Pen Dosage Chart
| Selank Pen 10 mg | |
|---|---|
| Volume | 2.0 mL (after reconstitution) |
| mg/mL | 5.0 mg/mL |
| Click-to-Dose | 1 click = 0.05 mg |
| Example(s) | 30 clicks = 1.5 mg; 60 clicks = 3 mg |
Dosage & Protocols Variations
Standard Research Protocol
- Dose: 0.25 – 0.5 mg (= 5–10 clicks)
- Duration: 2 – 3 weeks
- Frequency: Daily (SubQ)
- Cycle Interval: 2 – 4 weeks off before repeating
- Goal / Description: Baseline protocol for anxiolytic and cognitive stability models.
Therapeutic Research Protocol
- Dose: 0.5 – 0.9 mg (= 10–18 clicks)
- Duration: 3 – 4 weeks
- Frequency: 2× daily, divided doses
- Cycle Interval: 4 weeks off before repeating
- Goal / Description: Higher-dose protocol used in stress-response and GABAergic modulation studies.
Biohacker Protocol (experimental)
- Dose: 0.1 – 0.2 mg (= 2–4 clicks)
- Duration: 4 – 6 weeks
- Frequency: Daily microdose
- Cycle Interval: 2 weeks off before repeating
- Goal / Description: Low-dose continuous exposure for cognitive and mood-balance research.
Stacked Protocol (Selank + Semax)
- Dose: 0.3 mg Selank + 0.3 mg Semax (= 6 clicks)
- Duration: 2 – 3 weeks
- Frequency: Daily
- Cycle Interval: 3 – 4 weeks off before repeating
- Goal / Description: Combined neuropeptide protocol for cognitive and anxiolytic research models.
Possible Side Effects
Selank is generally well-tolerated in animal and limited human clinical studies, with no significant adverse effects reported at standard research doses.
Reported observations include:
- Mild transient drowsiness or fatigue during initial dosing.
- Occasional headache or lightheadedness in sensitive subjects.
- Localized irritation or redness at the injection site.
- Rare reports of mild nasal discomfort with intranasal administration.
Unlike classical anxiolytics, Selank has not been observed to produce sedation, dependence, withdrawal, or cognitive impairment in available research data. No evidence of hormonal, hepatic, or cardiovascular adverse effects has been documented.
Product Attributes
- CAS #: 129954-34-3
- Molecular Formula: C33H57N11O9
- Sequence (AA): TKPRPGP-NH2
- Molecular Weight: 751.88 g/mol
- PubChem CID: 11765620
- Half-Life: ~30 minutes (intranasal); extended central activity reported
- Synonyms: TP-7, Tuftsin analog, Threonyl-Lysyl-Prolyl-Arginyl-Prolyl-Glycyl-Proline amide
- Type: Synthetic research heptapeptide (regulatory neuropeptide)
- Research Focus: Cognitive & Neurological Research, Stress & Anxiety Modulation
Scientific References
- Anxiolytic activity of the heptapeptide Selank in clinical trials Human RCT | Observational
- Effects of Selank on the expression of genes encoding inflammatory factors and BDNF Animal | In vitro
- Selank enhances the expression of BDNF and the trkB receptor in the hippocampus Animal
- Comparative study of the anxiolytic effects of Selank and medazepam in patients with generalized anxiety disorder Human RCT
- Effect of Selank on monoamine neurotransmitter metabolism in the brain of rats Animal
- Selank and its analogs modulate GABAergic transmission in experimental anxiety models Animal | In vitro
- Peptide Selank as a candidate for the correction of cognitive deficits Animal
- Immunomodulatory and anxiolytic properties of the synthetic peptide Selank Observational | Animal
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.
For this reason, we accept mainly Bank Transfers.
We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.
Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.
This method ensures compliance, security, and continuity of service for all customers across the EU.
Didn't find the answer to your question?
View all frequently asked questionsRELATED PRODUCTS
