Cardiogen
Cardiogen is a synthetic short-chain peptide bioregulator derived from research on cardiac tissue, studied for its potential to support cardiomyocyte function and vascular integrity. It has been investigated in experimental models for its role in cardiac regeneration, endothelial repair, and modulation of age-related cardiovascular decline.
59,00 €
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Bioregulator - Advancedsave 86,00 €View the stack →Cardiogen - Cardiac Bioregulator Peptide for Heart Tissue Research
Description
Cardiogen is a synthetic tetrapeptide bioregulator composed of the amino acid sequence Ala-Glu-Asp-Arg (AEDR), developed within the Russian peptide bioregulator research tradition pioneered by Khavinson. It is studied for its tissue-specific affinity to cardiac and vascular cells, where it appears to modulate gene expression patterns associated with myocardial homeostasis.
In experimental models, Cardiogen has been observed to support cardiomyocyte viability, enhance endothelial function, and regulate vascular tone through epigenetic modulation of gene transcription in cardiac tissue. Research suggests upregulation of repair-associated proteins and improved mitochondrial activity in stressed myocardial cells.
Cardiogen has also been investigated for its antioxidant and cytoprotective properties, with reports of reduced oxidative damage and improved microcirculation in aged or ischemic cardiac models. These effects position it within the broader research field of peptide-based cardiovascular bioregulation.
Supplied as a lyophilized powder for reconstitution, Cardiogen is intended exclusively for laboratory and experimental use under controlled research conditions.
Clinical Status:
Cardiogen is a research peptide bioregulator evaluated primarily in animal models and limited observational studies within the Khavinson peptide research framework. It is not approved for medical use and remains restricted to experimental and laboratory research.
Evidence type:
Human RCT ☐ | Observational ✔ | Animal ✔ | In vitro ✔ | Regulatory ☐
Mechanism of Action
Cardiogen works by penetrating cardiomyocyte and endothelial cell nuclei, where it appears to interact with specific DNA regions and modulate the expression of genes involved in cardiac tissue maintenance. As a short peptide bioregulator, it is studied for its ability to regulate protein synthesis in cardiac and vascular cells, supporting mitochondrial function and endothelial integrity. This selective gene-regulatory activity has been linked with improved cardiomyocyte resilience, reduced oxidative stress, and enhanced vascular repair in experimental models.
Benefits
- Cardiomyocyte Function Support:
Cardiogen has been studied for its capacity to support the structural and functional integrity of cardiomyocytes in experimental models. Research suggests it may modulate gene expression involved in contractile protein synthesis and cellular energy regulation. This has positioned it as a peptide of interest in cardiac aging and regeneration studies, where preservation of myocardial cellular function is a primary research focus. - Endothelial Repair and Vascular Integrity:
Investigated for its tissue-specific affinity to vascular endothelial cells, Cardiogen appears to support endothelial regeneration and the maintenance of vascular barrier function. In experimental models, it has been observed to influence factors involved in capillary remodeling and microvascular health. This makes it a relevant candidate in research focused on vascular aging, endothelial dysfunction, and circulatory adaptation. - Modulation of Myocardial Gene Expression:
As a short-chain peptide bioregulator, Cardiogen has been reported to penetrate cell nuclei and interact with specific DNA regions in cardiac tissue. Research indicates this interaction may regulate the transcription of genes associated with cardiomyocyte maintenance, protein synthesis, and cellular repair pathways. This epigenetic-like influence is central to its classification within the Khavinson bioregulator research framework. - Cardiac Tissue Regeneration in Aging Models:
Cardiogen has been evaluated in aging-related experimental models for its potential role in supporting cardiac tissue renewal. Observations suggest it may help restore proliferative activity in aged cardiac cells and support the regeneration of functional myocardial structures. This places it among the peptide bioregulators studied for age-associated tissue decline and cardiac longevity research. - Blood Pressure and Hemodynamic Modulation:
Experimental studies have explored Cardiogen for its influence on hemodynamic parameters, including blood pressure regulation and vascular tone. Research models suggest it may support the normalization of cardiovascular markers through endothelial and autonomic pathways. This area of investigation has made it relevant in research models exploring hypertensive and ischemic cardiac conditions. - Oxidative Stress and Inflammatory Modulation:
Cardiogen has been reported to influence markers of oxidative stress and inflammation within cardiac and vascular tissues in experimental models. It appears to support the regulation of antioxidant defense systems and modulate pro-inflammatory signaling associated with myocardial injury. This dual modulatory role contributes to its interest in research on cardiovascular protection and ischemia-reperfusion models. - Post-Ischemic Recovery Support:
In preclinical investigations of myocardial ischemia and reperfusion injury, Cardiogen has been observed to support recovery of cardiac function and reduce markers of tissue damage. Research suggests it may enhance cellular survival pathways and support angiogenic factors involved in myocardial repair. This has positioned it as a peptide of interest in research models focused on cardiac recovery and remodeling. - Cardiovascular Aging and Longevity Research:
Cardiogen is studied within the broader Khavinson bioregulator framework as a peptide associated with cardiovascular system longevity. Long-term experimental observations suggest it may contribute to the preservation of cardiac and vascular function over time. This has made it a recurring subject in research on biological aging, peptide-based geroprotection, and organ-specific functional reserve.
Research Data
| Study / Model | Reported effect |
|---|---|
| Aged rat cardiomyocyte cultures | ↑ protein synthesis, ↑ cellular viability, restored functional markers toward younger phenotype |
| Experimental myocardial ischemia (rat model) | ↓ infarct size, ↑ capillary density, improved post-ischemic contractile recovery |
| Endothelial cell cultures under oxidative stress | ↓ apoptosis markers, ↑ NO synthase activity, preserved monolayer integrity |
| Aging cardiovascular rodent model | ↑ lifespan indicators, ↓ age-related myocardial fibrosis markers |
| Observational human studies (elderly cohorts) | Improved ECG parameters and reported cardiac functional indices |
| In vitro gene expression assays | Modulation of cardiac-specific transcription factors and contractile protein genes |
| Post-infarction recovery models | Accelerated tissue remodeling and reduced inflammatory infiltration |
Stack Suggestions
Cardiogen is often combined in research with:
- Cardiogen + Vesugen → Supports vascular endothelial integrity alongside cardiomyocyte regulation.
- Cardiogen + Ventfort → Enhances vascular wall remodeling and endothelial repair pathways.
- Cardiogen + Epitalon → Combines cardiac bioregulation with broader cellular longevity signaling.
- Cardiogen + SS-31 → Pairs cardiac peptide regulation with mitochondrial protection in cardiomyocyte models.
⚠ Stacks are for experimental design only; not safety or efficacy guidance.
Pen Dosage Chart
| Cardiogen Pen 20 mg | |
| Volume | 2 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.1 mg |
| Example(s) | 10 clicks = 1 mg |
Dosage & Protocols Variations
Standard Research Protocol
- Dose: 2 – 4 mg
- Duration: 2 – 4 weeks
- Frequency: Daily
- Cycle Interval: 4 – 6 months off before repeating
- Goal / Description: Baseline protocol for cardiac and vascular tissue research models.
Therapeutic Research Protocol
- Dose: 4 – 6 mg
- Duration: 3 – 4 weeks
- Frequency: Daily
- Cycle Interval: 4 – 6 months off before repeating
- Goal / Description: Higher-dose protocol for targeted cardiomyocyte and endothelial repair studies.
Biohacker Protocol (experimental)
- Dose: 1 – 2 mg
- Duration: 4 – 6 weeks
- Frequency: 5× per week
- Cycle Interval: 2 – 3 months off before repeating
- Goal / Description: Microdose continuous approach for longevity and vascular maintenance research.
Possible Side Effects
Cardiogen is generally well-tolerated in animal studies and limited human observational research within the Russian peptide bioregulator tradition.
Reported side effects are rare and mild:
- Localized irritation or redness at injection site.
- Transient mild headache during initial dosing period.
- Occasional fatigue or drowsiness reported in sensitive subjects.
- Mild gastrointestinal sensitivity when administered orally in sublingual formulations.
No evidence of cardiotoxic, hormonal, or systemic adverse effects has been observed in available data.
Product Attributes
- CAS #: N/A (research bioregulator)
- Molecular Formula: C17H30N8O8
- Sequence (AA): AEDR
- Molecular Weight: ~474.5 g/mol
- PubChem CID: N/A
- Half-Life: ~2-4 hours
- Synonyms: Ala-Glu-Asp-Arg, AEDR peptide, Cardiac bioregulator
- Type: Synthetic short-chain peptide bioregulator (cardiac-specific)
- Research Focus: Cardiovascular Health, Tissue Regeneration
Scientific References
- Peptide regulation of cardiomyocyte functions during aging Animal | In vitro
- Cardiogen peptide effects on heart tissue regeneration in experimental models Animal
- Peptide bioregulators: a new class of geroprotectors. Khavinson review Observational | Animal | In vitro
- Short peptides regulate gene expression and protein synthesis in tissues In vitro
- Tetrapeptides as tissue-specific bioregulators: mechanisms and applications Animal | In vitro
- Peptide regulation of vascular endothelial function in aging models Animal
- Cytogens and short peptides in cardiovascular research: experimental evidence Observational | Animal
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.
For this reason, we accept mainly Bank Transfers.
We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.
Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.
This method ensures compliance, security, and continuity of service for all customers across the EU.
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