Ipamorelin
Ipamorelin is a selective growth hormone secretagogue studied for its role in stimulating natural growth hormone release through ghrelin receptor activation. Unlike earlier growth hormone releasing peptides, Ipamorelin demonstrates a more targeted signaling profile with minimal impact on cortisol or prolactin pathways. In research settings, it has been observed to support recovery signaling, sleep-related GH pulses, and anabolic hormone modulation. Formulated in a stabilized pre-mixed injection pen for research use only.
51,00 €
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Ipamorelin - Natural Growth Hormone Support & Recovery Enhancement
Description
Ipamorelin is a selective ghrelin receptor (GHS-R1a) agonist belonging to the growth hormone releasing peptide (GHRP) family. It stimulates pulsatile growth hormone (GH) release from the anterior pituitary by mimicking endogenous ghrelin signaling. Compared to earlier GHRPs, Ipamorelin is known for its receptor selectivity and reduced stimulation of cortisol and prolactin pathways.
Our formulation is provided in a stabilized pre-mixed injection pen for SubQ administration. Subcutaneous delivery supports controlled systemic exposure and predictable GH pulse activation in research protocols. Each unit is freshly prepared to preserve peptide integrity and standardized dosing. The product is intended strictly for laboratory and research use only.
In human and animal research, Ipamorelin has been studied for its ability to increase circulating growth hormone levels while maintaining endocrine balance. Research domains include muscle recovery studies, sleep-related hormone pulse investigations, and age-associated GH decline research contexts.
Clinical Status
Human RCT ▣ | Observational ▣ | Animal ✔ | In vitro ✔
Primarily studied in preclinical and exploratory human growth hormone modulation research contexts.
Mechanism of Action
Ipamorelin stimulates natural growth hormone release by activating ghrelin receptors in the pituitary gland. This activation triggers pulsatile GH secretion while maintaining upstream hypothalamic regulation. Its selective receptor profile supports GH release without significant stimulation of stress-related hormones.
Benefits
- Supports natural growth hormone pulses:
Ipamorelin works by stimulating your body’s own growth hormone release rather than replacing it with synthetic GH. This means the pituitary gland remains active and responsive. Growth hormone is normally released in pulses throughout the day, especially during deep sleep. By encouraging this natural rhythm, Ipamorelin supports a more physiological hormone pattern. This approach helps maintain endocrine balance instead of bypassing regulatory systems. - Encourages recovery through endogenous pathways:
Growth hormone plays an important role in tissue repair, muscle recovery, and protein synthesis. By stimulating natural GH release, Ipamorelin indirectly supports the body’s recovery signaling network. This includes downstream IGF-1 production, which is involved in structural repair processes. Instead of forcing supraphysiological levels, it works within the body’s own hormone framework. - Maintains hormonal feedback integrity:
One of the key differences between stimulating GH and injecting it directly is preservation of feedback loops. Ipamorelin activates the pituitary while keeping hypothalamic regulation intact. This means the body can still modulate output based on its needs. Maintaining this feedback system is important in research focused on long-term endocrine stability. - Selective stimulation with minimal stress-hormone impact:
Earlier growth hormone releasing peptides were associated with increased cortisol or prolactin levels. Ipamorelin was designed to be more selective at the ghrelin receptor. This selectivity allows GH stimulation without significant activation of stress-related hormone pathways. The result is a cleaner hormonal profile in experimental settings. - Supports sleep-associated hormone cycles:
Growth hormone release naturally peaks during deep sleep stages. Ipamorelin has been studied for its ability to enhance physiologic nighttime GH pulses. Since sleep quality and recovery are closely linked to hormone rhythms, this timing alignment is relevant in recovery-focused research models. - Engages downstream IGF-1 signaling:
When growth hormone increases, the liver produces insulin-like growth factor 1 (IGF-1). IGF-1 is associated with muscle repair, cellular growth, and metabolic signaling. By stimulating GH first, Ipamorelin activates this secondary pathway in a stepwise, physiological manner. This layered response mimics the body’s natural hormone cascade. - Explored in age-related hormone decline models:
Natural growth hormone production decreases over time. Ipamorelin has been evaluated in research examining reduced GH levels associated with aging. Rather than introducing external hormones, it encourages the body to resume endogenous production patterns. This makes it relevant in studies of endocrine aging biology. - Supports structured, controlled hormone research:
Provided in a stabilized pre-mixed injection pen for SubQ administration, Ipamorelin allows consistent exposure in controlled research protocols. Subcutaneous delivery enables predictable absorption. Each unit is freshly prepared and intended strictly for laboratory use only.
Research Data
| Study / Model | Reported effect |
|---|---|
| Rat pituitary cell culture | ↑ GH release via selective GHS-R1a activation, minimal cortisol or prolactin response |
| Healthy adult human pharmacology study | Dose-dependent ↑ in serum GH and IGF-1 without significant ACTH elevation |
| Aged rat model | Restored pulsatile GH secretion patterns and ↑ lean body mass over 14 days |
| Post-operative ileus clinical trial | Accelerated gastrointestinal motility recovery and reduced time to first bowel movement |
| Glucocorticoid-induced osteopenia model | ↑ bone mineral density and improved trabecular bone architecture |
| Catabolic state in rodents | ↓ nitrogen loss, ↑ protein synthesis and improved recovery markers |
| In vitro pituitary somatotroph assay | Selective GH secretagogue activity confirmed without cross-activation of HPA axis |
Stack Suggestions
Ipamorelin is often combined in research with:
- Ipamorelin + CJC-1295 → Synergistic GH pulse amplification through combined GHRH and ghrelin pathway activation.
- Ipamorelin + BPC-157 → Enhances tissue recovery models by pairing GH-mediated repair with cytoprotective regeneration.
- Ipamorelin + Tesamorelin → Supports lean mass and metabolic models via complementary GHRH and GHS signaling.
- Ipamorelin + MK-677 → Extends GH and IGF-1 elevation through combined short- and long-acting ghrelin receptor activation.
⚠ Stacks are for experimental design only; not safety or efficacy guidance.
Pen Dosage Chart
| Ipamorelin Pen 10 mg | |
|---|---|
| Volume | 2 mL |
| mg/mL | 5 mg/mL |
| Click-to-Dose | 1 click = 0.05 mg |
| Example(s) | 10 clicks = 0.5 mg |
Dosage & Protocols Variations
Standard Research Protocol
- Dose: 0.2 – 0.3 mg (= 4–6 clicks)
- Duration: 8 – 12 weeks
- Frequency: 1 – 2× daily (pre-sleep and/or pre-training)
- Cycle Interval: 4 weeks off before repeating
- Goal / Description: Baseline GH pulse stimulation in recovery and body composition models.
Therapeutic Research Protocol
- Dose: 0.3 – 0.5 mg (= 6–10 clicks)
- Duration: 12 weeks
- Frequency: 2 – 3× daily, spaced 4 – 6 hours apart
- Cycle Interval: 4 – 6 weeks off before repeating
- Goal / Description: Higher-amplitude GH and IGF-1 elevation in regenerative and metabolic models.
Biohacker Protocol (experimental)
- Dose: 0.1 – 0.15 mg (= 2–3 clicks)
- Duration: Continuous
- Frequency: Once nightly, pre-sleep
- Cycle Interval: 5 days on / 2 days off
- Goal / Description: Low-dose nocturnal GH support investigated in sleep and longevity research.
Stacked Protocol (Ipamorelin + CJC-1295)
- Dose: 0.2 – 0.3 mg Ipamorelin + 0.1 mg CJC-1295 (= 4–6 clicks)
- Duration: 8 – 12 weeks
- Frequency: 1 – 2× daily
- Cycle Interval: 4 weeks off before repeating
- Goal / Description: Synergistic GHRH + GHRP combination studied for amplified GH pulse and IGF-1 response.
Possible Side Effects
Ipamorelin is generally well-tolerated in preclinical and limited human research studies, with a favorable safety profile compared to earlier growth hormone releasing peptides.
Reported side effects are typically mild and transient:
- Localized redness, irritation, or swelling at the injection site.
- Transient headache or light-headedness following administration.
- Mild flushing or warmth shortly after dosing.
- Temporary increase in appetite due to ghrelin receptor activation.
- Occasional fatigue or drowsiness in initial dosing periods.
- Minor water retention or numbness in extremities at higher doses.
No evidence of significant cortisol elevation, prolactin disturbance, or hepatic adverse effects has been observed in available research data.
Product Attributes
- CAS #: 170851-70-4
- Molecular Formula: C38H49N9O5
- Sequence (AA): Aib-His-D-2-Nal-D-Phe-Lys-NH2
- Molecular Weight: 711.86 g/mol
- PubChem CID: 11226745
- Half-Life: ~2 hours
- Synonyms: NNC 26-0161, Ipamorelin acetate
- Type: Synthetic research peptide (selective growth hormone secretagogue, GHRP)
- Research Focus: Growth Hormone Modulation, Recovery & Performance, Longevity & Anti-Aging
Scientific References
- Ipamorelin, the first selective growth hormone secretagogue Animal | In vitro
- Growth hormone secretagogues: history, mechanism of action and clinical development Observational | Animal | In vitro
- The growth hormone-releasing effect of ipamorelin in human volunteers Human RCT | Observational
- Ipamorelin prevents bone loss and accelerates fracture healing in ovariectomized rats Animal
- Ghrelin receptor signaling: a promising therapeutic target Animal | In vitro
- Effects of ipamorelin on body composition and bone formation in growing rats Animal
- Ulimorelin and ipamorelin in postoperative ileus: phase 2 clinical trial Human RCT
- Ipamorelin: research summary on growth hormone release and tolerability Observational | Animal
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.
For this reason, we accept mainly Bank Transfers.
We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.
Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.
This method ensures compliance, security, and continuity of service for all customers across the EU.
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