Cell Renewal - Start
Cell Renewal - Start Original price was: 359,00 €.Current price is: 305,00 €.
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Longevity - Start
Longevity - Start Original price was: 345,00 €.Current price is: 293,00 €.

Cell Renewal – Advanced

The Cell Renewal – Advanced expands the Start protocol to six complementary compounds: the telomerase peptide Epithalon, the senolytic FOXO4-DRI, the mitochondrial-derived peptide Humanin, cellular coenzyme NAD+, the mitochondrial-targeted SS-31 and master-antioxidant Glutathione.

Built for deeper research into senescence clearance, mitochondrial protection and telomere biology – a complete bundled set at a single discounted price.

Original price was: 678,00 €.Current price is: 509,00 €.

The expanded 6-part longevity protocol: Epithalon, FOXO4-DRI, Humanin, NAD+, SS-31 and Glutathione.

What's included in this stack

Total value: 678,00  You save 169,00  -25%
Targeted Senescent Clearance
via FOXO4-DRI senolytic

Description

Mechanism of Action​

The Cell Renewal – Advanced bundle is designed for comprehensive investigation into cellular aging. Epithalon is studied for telomerase activation and telomere maintenance, while the senolytic FOXO4-DRI is researched for selective clearance of senescent cells. Humanin and SS-31 are investigated for mitochondrial protection and cardiolipin stabilization, NAD+ for sirtuin signaling and energy metabolism, and Glutathione for redox balance, together offering a synergistic platform for advanced longevity research.

Benefits

  • Targeted Senescent Clearance – FOXO4-DRI is researched for its selective disruption of senescent cell survival pathways, potentially reducing the burden of dysfunctional cells.
  • Enhanced Mitochondrial Bioenergetics – NAD+, Humanin, and SS-31 are investigated for their roles in optimizing mitochondrial function, ATP production, and overall cellular energy efficiency.
  • Genomic Stability Support – Epithalon is studied for its influence on telomerase activity and telomere maintenance, which are critical for preserving genomic integrity.
  • Master Antioxidant Defense – Glutathione is researched as a master antioxidant and for its role in regenerating other antioxidants, supporting cellular protection against oxidative stress.
  • DNA Repair & Longevity – NAD+ is investigated as a vital cofactor for sirtuin activation and PARP enzymes, which are crucial for DNA repair and cellular longevity pathways.
  • Neuroprotection & Cognition – Humanin and Glutathione are studied for their potential to protect neuronal cells from various stressors and support cognitive function.
  • Metabolic & Circadian Balance – NAD+ and Humanin are researched for their influence on glucose homeostasis, insulin sensitivity, and the alignment of cellular processes with circadian rhythms.
  • Reduced Inflammatory Signaling – Humanin, NAD+, and FOXO4-DRI are investigated for their roles in attenuating pro-inflammatory cytokine release and reducing the senescence-associated secretory phenotype (SASP).

Research Data​

Epithalon

Study / ModelReported effect
Human somatic cell culture↑ Telomerase activity, ↑ telomere length in dividing cells
Aged mice longevity studiesExtended median lifespan, ↓ age-related tumor incidence
Pineal gland animal modelsRestored melatonin secretion rhythm, normalized circadian markers
Elderly human observational cohortImproved sleep architecture, ↑ nocturnal melatonin levels
Retinal degeneration rat model↓ Photoreceptor loss, preserved retinal pigment epithelium
Oxidative stress in vitro assays↓ Lipid peroxidation, ↑ antioxidant enzyme expression
Immunosenescence rodent studiesRestored T-cell function, normalized thymic activity

FOXO4-DRI (Proxofim)

Study / ModelReported effect
Naturally aged mice↑ fur density, ↑ renal function markers, improved physical activity
Doxorubicin-induced senescence modelSelective clearance of senescent cells, reduced tissue damage
Xpd TTD/TTD progeroid miceRestored fitness, ↓ senescence-associated markers in multiple tissues
In vitro senescent fibroblasts (IMR90)Targeted apoptosis via FOXO4–p53 disruption; healthy cells unaffected
Aged mouse kidney tissue↓ p21 expression, ↓ SASP factors, improved glomerular function
Liver tissue in aged modelsReduced senescent cell burden, ↑ hepatic regeneration markers

Humanin

Study / ModelReported effect
Alzheimer’s disease cellular models↓ neuronal apoptosis induced by amyloid-beta toxicity; preserved cell viability
Aged mouse models↑ insulin sensitivity; improved glucose homeostasis and metabolic markers
Ischemia-reperfusion (cardiac models)↓ infarct size; cardioprotection via STAT3 signaling activation
In vitro mitochondrial assays↑ mitochondrial respiration and ATP production; reduced oxidative stress
Human centenarian observational dataHigher circulating humanin levels correlated with longevity and metabolic health
Optic nerve injury modelsRetinal ganglion cell survival enhanced; neuroprotective signaling preserved
Atherosclerosis rodent models↓ plaque formation; reduced vascular inflammation markers

NAD+

Study/modelReported effect
Human clinical trials (IV NAD+ administration)

↑ plasma NAD+ by 4-6×; improved fatigue and alertness scores

Animal models (aged mice)

Restored mitochondrial function and ↑ lifespan by 15-20%

Cellular aging models

Activation of SIRT1 and PARP1 → enhanced DNA repair and mitochondrial biogenesis

Human observational studies

Correlation between low NAD+ and metabolic dysfunction, insulin resistance

In vitro neuronal cultures

Protection from oxidative and excitotoxic stress; improved neurite outgrowth

Metabolic disorder models

↓ triglycerides and hepatic steatosis via AMPK activation

Exercise recovery studies

↑ muscle NAD+/NADH ratio and improved endurance performance

Brain ischemia models

↓ infarct size and enhanced neuronal survival post-injury

SS-31

Study / ModelReported effect
Aged mouse skeletal muscle↑ ATP production, ↓ oxidative damage, improved mitochondrial coupling efficiency
Ischemia-reperfusion cardiac model↓ infarct size, preserved mitochondrial cristae structure and membrane potential
Primary mitochondrial myopathy (clinical)Improved 6-minute walk distance and reduced patient-reported fatigue
Diabetic nephropathy rodent model↓ renal oxidative stress, preserved glomerular function and tubular integrity
Heart failure (HFrEF) early trialsTrends toward improved left ventricular function and exercise tolerance
In vitro cardiolipin-binding assaysSelective localization to inner mitochondrial membrane, stabilized ETC complexes
Age-related macular degeneration trialsImproved low-luminance visual acuity and retinal function markers

Glutathione

Study/modelReported effect
Human trials (oral and IV administration)

↑ Plasma GSH levels, ↓ oxidative biomarkers (MDA, 8-OHdG)

Animal oxidative stress models

↓ Lipid peroxidation and improved mitochondrial GSH:GSSG ratio

Hepatotoxicity models (CCl4, acetaminophen)

↓ ALT/AST, ↓ hepatic necrosis, improved antioxidant enzyme activity

Neurodegenerative disease models

Protection of dopaminergic neurons and ↓ oxidative stress markers

In vitro melanocyte cultures

↓ Tyrosinase activity and melanin synthesis via GSH-mediated inhibition

Inflammatory models

↓ TNF-α, IL-6, and CRP, supporting immunomodulatory roles

Pharmacokinetic assessments

↑ Cellular uptake with liposomal and SubQ formulations

Stack Suggestions​

This bundle is suited for researchers investigating cellular senescence, mitochondrial decline and telomere biology in advanced research models, providing a robust framework across senolytic, mitochondrial-protective and antioxidant pathways.

Pen Dosage Chart​

Epithalon

Epithalon Pen 20 mg
Volume2 mL
mg/mL10 mg/mL
Click-to-Dose1 click = 0.1 mg
Example(s)10 clicks = 1 mg

FOXO4-DRI (Proxofim)

FOXO4-DRI (Proxofim) Pen 10 mg
Volume2 mL
mg/mL5 mg/mL
Click-to-Dose1 click = 0.05 mg
Example(s)10 clicks = 0.5 mg

Humanin

Humanin Pen 10 mg
Volume2 mL
mg/mL5 mg/mL
Click-to-Dose1 click = 0.05 mg
Example(s)10 clicks = 0.5 mg

NAD+

NAD+ Pen 500 mg
Volume3.0 mL
mg/mL166.67 mg/mL
Click-to-Dose1 click = 1.67 mg
Example(s)30 clicks = 50 mg
NAD+ Pen 1000 mg
Volume3.0 mL
mg/mL333.33 mg/mL
Click-to-Dose1 click = 3.33 mg
Example(s)15 clicks = 50 mg

SS-31

SS-31 Pen 10 mg
Volume2 mL
mg/mL5 mg/mL
Click-to-Dose1 click = 0.05 mg
Example(s)10 clicks = 0.5 mg

Glutathione

Glutathione Pen 1500 mg
Volume3 mL
mg/mL500 mg/mL
Click-to-Dose1 click = 5 mg
Example(s)10 clicks = 50 mg

Dosage & Protocols Variations​

Epithalon

Standard Research Protocol

  • Dose: 5 – 10 mg (= 50–100 clicks)
  • Duration: 2 – 3 weeks
  • Frequency: Daily
  • Cycle Interval: 4 – 6 months off before repeating
  • Goal / Description: Baseline protocol used in telomerase activation and cellular aging models.

Therapeutic Research Protocol

  • Dose: 10 – 20 mg (= 100–200 clicks)
  • Duration: 10 – 20 days
  • Frequency: Daily or split into two administrations
  • Cycle Interval: 3 – 6 months off before repeating
  • Goal / Description: Higher-dose schedule explored in longevity and pineal signaling research.

Biohacker Protocol (experimental)

  • Dose: 2 – 5 mg (= 20–50 clicks)
  • Duration: 4 – 6 weeks
  • Frequency: 5 days per week
  • Cycle Interval: 2 – 3 months off before repeating
  • Goal / Description: Microdose continuous approach in experimental aging models.

FOXO4-DRI (Proxofim)

Standard Research Protocol

  • Dose: 1.0 – 5.0 mg (= 20–100 clicks)
  • Duration: 3 consecutive days
  • Frequency: Once every 2 weeks (intermittent pulse)
  • Cycle Interval: 2 – 4 weeks off before repeating
  • Goal / Description: Baseline senolytic pulsing observed in preclinical aging models.

Therapeutic Research Protocol

  • Dose: 5.0 – 10.0 mg (= 100–200 clicks)
  • Duration: 3 consecutive days per cycle
  • Frequency: 1 cycle every 3 – 4 weeks
  • Cycle Interval: 3 – 4 weeks off before repeating
  • Goal / Description: Higher-dose pulse evaluated for accelerated senescent cell clearance in research models.

Biohacker Protocol (experimental)

  • Dose: 0.5 – 1.0 mg (= 10–20 clicks)
  • Duration: 3 consecutive days
  • Frequency: Once every 4 – 6 weeks
  • Cycle Interval: 4 – 6 weeks off before repeating
  • Goal / Description: Microdose pulsing investigated for cumulative senolytic effects with minimal exposure.

Humanin

Standard Research Protocol

  • Dose: 1 – 5 mg
  • Duration: 4 – 8 weeks
  • Frequency: Daily or every other day
  • Cycle Interval: 4 weeks off before repeating
  • Goal / Description: Baseline protocol for mitochondrial and metabolic research models.

Therapeutic Research Protocol

  • Dose: 5 – 10 mg
  • Duration: 6 – 12 weeks
  • Frequency: Daily
  • Cycle Interval: 4 – 6 weeks off before repeating
  • Goal / Description: Higher-dose protocol for neuroprotection and insulin sensitivity studies.

Biohacker Protocol (experimental)

  • Dose: 0.5 – 1 mg
  • Duration: Continuous
  • Frequency: Daily microdose
  • Cycle Interval: 2 weeks off every 8 weeks
  • Goal / Description: Low-dose continuous use in longevity and cellular stress models.

NAD+

Standard Cellular Support

  • Dose: 50 – 100 mg (variant 500 mg pen = 30–60 clicks / variant 1000 mg pen = 15–30 clicks)
  • Duration: 8 – 12 weeks
  • Frequency: Every Other Day
  • Cycle Interval:  4-week rest
  • Goal / Description: Common research design for mitochondrial and energy studies

Intensive Regeneration Protocol

  • Dose: 100 – 250 mg (variant 500 mg pen = 60–150 clicks / variant 1000 mg pen = 30–75 clicks)
  • Duration: 8 – 12 weeks
  • Frequency: 1× daily
  • Cycle Interval: 8-week rest
  • Goal / Description: Applied in models focusing on recovery and DNA repair

Neurocognitive Focus Protocol

  • Dose: 50 mg (variant 500 mg pen = 30 clicks / variant 1000 mg pen = 15 clicks)
  • Duration: 8 – 12 weeks
  • Frequency: 1× daily (morning)
  • Cycle Interval: 4-week rest
  • Goal / Description: Studied for neuronal resilience and alertness optimization

Longevity & Metabolic Protocol

  • Dose: 50 – 150 mg (variant 500 mg pen = 30–90 clicks / variant 1000 mg pen = 15–45 clicks)
  • Duration: 8 – 12 weeks
  • Frequency: Every Other Day
  • Cycle Interval: 8-week rest
  • Goal / Description: Designed for long-term metabolic and aging research

SS-31

Standard Research Protocol

  • Dose: 1 – 5 mg (= 20–100 clicks)
  • Duration: 4 – 8 weeks
  • Frequency: Daily (subcutaneous)
  • Cycle Interval: 2 – 4 weeks off before repeating
  • Goal / Description: Baseline mitochondrial support and cardiolipin stabilization in research models.

Therapeutic Research Protocol

  • Dose: 5 – 10 mg (= 100–200 clicks)
  • Duration: 6 – 12 weeks
  • Frequency: Daily
  • Cycle Interval: 4 weeks off before repeating
  • Goal / Description: Higher-dose protocol for models focused on cardiac, renal, or neurodegenerative mitochondrial dysfunction.

Biohacker Protocol (experimental)

  • Dose: 0.5 – 1 mg (= 10–20 clicks)
  • Duration: 8 – 12 weeks
  • Frequency: Daily microdose
  • Cycle Interval: Continuous with periodic 1 – 2 week pauses
  • Goal / Description: Low-dose continuous exposure for longevity and oxidative-stress modulation studies.

Stacked Protocol (SS-31 + MOTS-c)

  • Dose: 3 – 5 mg SS-31 + 5 mg MOTS-c (= 60–100 clicks)
  • Duration: 4 – 6 weeks
  • Frequency: Daily
  • Cycle Interval: 4 weeks off before repeating
  • Goal / Description: Combined mitochondrial biogenesis and membrane stabilization in metabolic research models.

Glutathione

Standard Antioxidant Protocol

  • Dose: 200 – 400 mg (= 40–80 clicks)
  • Duration: 4 – 8 weeks
  • Frequency: 3× weekly
  • Cycle Interval: 4-week rest
  • Goal / Description: ↑ Systemic antioxidant capacity, baseline redox support

Intensive Detoxification Protocol

  • Dose: 500 – 600 mg (= 100–120 clicks)
  • Duration: 4 weeks
  • Frequency: 5× weekly
  • Cycle Interval: 8-week rest
  • Goal / Description: Rapid ↑ GSH levels for detoxification models, tissue saturation

Maintenance Protocol

  • Dose: 150 mg (= 30 clicks)
  • Duration: 8 – 12 weeks
  • Frequency: 3× weekly
  • Cycle Interval: 8-week rest
  • Goal / Description: Long-term maintenance of improved GSH status

Possible Side Effects​

This bundle combines multiple research compounds; the per-compound safety notes below apply. For laboratory research use only – not for human consumption.

Epithalon

Epithalon is generally well-tolerated in preclinical and limited human observational studies.

Reported side effects are rare and typically mild:

  • Transient drowsiness or mild fatigue following administration.
  • Localized irritation, redness, or tenderness at injection site.
  • Occasional mild headache during initial dosing periods.
  • Temporary changes in sleep patterns linked to pineal signaling modulation.

No evidence of hormonal, hepatic, or systemic adverse effects has been observed in available research data.

FOXO4-DRI (Proxofim)

FOXO4-DRI has been evaluated almost exclusively in preclinical and animal studies, with limited safety data in higher organisms.

Observed effects in experimental models include:

  • Transient fatigue or lethargy following administration in animal models.
  • Mild injection-site irritation or localized inflammation.
  • Short-term changes in blood cell counts during senolytic clearance phases.
  • Potential renal stress markers reported in rodent studies at higher doses.

No evidence of long-term systemic, hormonal, or organ-specific toxicity has been reported in available preclinical data; however, human safety profiles remain undefined.

Humanin

Humanin is generally well-tolerated in preclinical and limited human studies, with no major adverse effects reported at research doses.

Observed effects in experimental models are rare and typically mild:

  • Transient injection site irritation or redness.
  • Mild headache or dizziness during initial dosing.
  • Occasional fatigue or drowsiness in early administration phases.
  • Minor gastrointestinal discomfort in sensitive subjects.

No evidence of hormonal, hepatic, or cardiovascular adverse effects has been observed in available data. Long-term safety profiles in humans remain under investigation, and Humanin is restricted to experimental and laboratory research.

NAD+

NAD+, as a research coenzyme boosting metabolism, may induce mild side effects in experimental models, primarily during initial administration. These are dose-dependent and often transient. It’s crucial to monitor for subcutaneous reactions.

Headache: Commonly observed at higher doses, manifesting as mild pressure, linked to vascular changes. It typically resolves within days.
Nausea: Occasional gastrointestinal upset, especially with rapid escalation. Frequency decreases with slower protocols.
Dizziness: Lightheadedness reported early on, possibly from energy shifts. Resolves as models adapt.
Flushing: Warm sensation or skin redness, attributed to niacin-like effects.
Fatigue: Paradoxical tiredness initially, due to metabolic adjustments.

Most side effects are minor and manageable through dose titration. Prolonged exposure warrants vigilance for rare issues like hypersensitivity, though uncommon in controlled settings.

SS-31

SS-31 (Elamipretide) has been generally well-tolerated in preclinical and early clinical research settings, with no severe adverse effects reported in available data.

Mild and transient effects observed in research include:

  • Localized injection-site reactions, including redness, mild swelling, or irritation.
  • Transient headache or dizziness during initial dosing periods.
  • Mild gastrointestinal discomfort or nausea in sensitive subjects.
  • Occasional fatigue or lightheadedness shortly after administration.

No evidence of hepatic, renal, or hormonal adverse effects has been observed in available research data. Long-term safety profiles remain under investigation in ongoing studies focused on mitochondrial-targeted therapeutics.

Glutathione

Glutathione supplementation is generally well-tolerated due to its endogenous nature, but some individuals may experience side effects, particularly with higher doses or sensitive constitutions. The most common adverse reactions are related to gastrointestinal adjustments and administration site responses with subcutaneous injection protocols.

Gastrointestinal Effects: Mild nausea, abdominal cramping, bloating, and flatulence may occur, especially during the initial supplementation period. These symptoms typically resolve as the body adapts to increased glutathione levels. Some users report a metallic or sulfur-like taste, which is attributed to the cysteine component of the molecule.

Injection Site Reactions: With subcutaneous administration, mild redness, swelling, or irritation at the injection site may occur. These reactions are typically transient and resolve within 24-48 hours. Proper injection technique and site rotation can minimize these effects.

Allergic Reactions: Although rare, some individuals may experience allergic responses including skin rashes, hives, or in severe cases, difficulty breathing. Those with known sensitivities to sulfur-containing compounds should exercise particular caution.

Respiratory Considerations: Individuals with asthma or respiratory sensitivities should avoid inhaled forms, as glutathione may trigger bronchospasms or respiratory distress in predisposed individuals.

Headaches and Fatigue: Some users report mild headaches or temporary fatigue during initial supplementation, likely related to detoxification processes and cellular adjustments to enhanced antioxidant capacity.

It is important to note that most side effects are mild, transient, and resolve with continued use or dosage adjustment. However, individuals should discontinue use and consult healthcare providers if adverse reactions persist or worsen.

Product Attributes​

Scientific References​

Epithalon

FOXO4-DRI (Proxofim)

Humanin

NAD+

SS-31

Glutathione

Included In The Box

Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:

  • 1× Disposable Pre-Mixed Injection Pen
  • Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
  • 10× Ultra-thin Needles (33G, 4 mm)
  • 10× Alcohol Pads for sterile preparation
  • Internal Stabilizing Foam Insert to prevent shaking during transport
  • Instruction Panel printed on the inside of the box for quick reference
  • Security Seal Sticker ensuring the package has not been opened or tampered with

Store the product in a refrigerator at 1 – 8°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.

Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.

Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.

For best results, use the product consistently within the recommended time window and always follow your research protocol.

We ship with Next-Day EU Delivery via DHL Express or UPS Express.

All orders are prepared fresh on the day of dispatch, placed in EPS Cold-Chain Transport Boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.

Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.

Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.

Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not generally support merchants in this field.

For this reason, we accept mainly Bank Transfers.

We also work with a crypto payment provider, and from time to time, card payments may be available depending on processor availability.

Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.

Once the transfer is received, your order is prepared immediately and dispatched the same day, depending on the daily cut-off time.

Please note that we do not dispatch shipments on Fridays or on days before official public holidays. This is done to ensure that parcels can be delivered on the next working day and are not held in transit over weekends or holidays.

This method ensures compliance, security, and continuity of service for all customers across the EU.

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