Sleep - Start
Sleep - Start Original price was: 212,00 €.Текущата цена е: 180,00 €.
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Glow - Start
Glow - Start Original price was: 306,00 €.Текущата цена е: 260,00 €.

Sleep – Advanced

Sleep Advanced builds on the Start kit with the pineal bioregulator Pinealon, the antioxidant Glutathione and the neuro-restorative bioregulator Cortagen, forming a six-peptide panel for research into restorative sleep, circadian regulation and overnight cellular recovery.

Supplied at research-grade purity. For research purposes only; not for human consumption.

Original price was: 392,00 €.Текущата цена е: 294,00 €.

Пълният панел за сън — DSIP, Selank, Epithalon, Pinealon, Glutathione и Cortagen за изследване на дълбокото възстановяване.

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Sleep - Advanced - Advanced Sleep & Circadian Rhythm Research

Delta Sleep Research

DSIP

Stress Adaptation Studies

Selank

Circadian Rhythm Modulation

Epithalon

Pineal Gland Support

Pinealon

Antioxidant Defense

Glutathione

Adrenal Function Research

Cortagen

Neuroprotective Pathways

Selank

Cellular Longevity Studies

Epithalon

Description

Mechanism of Action​

This advanced research stack explores multifaceted pathways influencing sleep architecture and stress resilience. DSIP and Pinealon are investigated for roles in sleep induction and pineal gland function. Selank and Cortagen research focuses on modulating stress responses and neuroprotection. Epithalon is studied for circadian rhythms and cellular longevity, while Glutathione supports cellular defense, offering a comprehensive research model.

Benefits

  • Sleep Architecture Research – Investigating DSIP’s role in delta sleep.
  • Stress Response Modulation – Exploring Selank and Cortagen’s influence.
  • Circadian Rhythm Studies – Examining Epithalon and Pinealon’s impact.
  • Cellular Defense Support – Researching Glutathione’s antioxidant properties.
  • Neuroprotection Pathways – Investigating Selank’s potential mechanisms.

Research Data​

DSIP

Study / ModelReported effect
Rodent EEG sleep studies↑ delta-wave activity and improved slow-wave sleep continuity
Stress-induced animal models↓ corticosteroid release and attenuated HPA-axis hyperactivity
Chronic insomnia observational researchImproved subjective sleep onset and reduced nocturnal awakenings
Opioid withdrawal clinical observations↓ withdrawal severity and improved autonomic stabilization
Oxidative stress in vitro assays↓ lipid peroxidation markers; antioxidant enzyme modulation
Neuroendocrine animal studiesModulation of GH, LH, and somatostatin secretion patterns
Pain perception rodent modelsElevated nociceptive thresholds and analgesic-like response

Selank

Study / ModelReported effect
Generalized anxiety disorder clinical trials↓ anxiety scores comparable to medazepam without sedation or withdrawal
Rat elevated plus-maze model↓ anxiety-like behavior; ↑ open-arm exploration time
Cortical neurotransmitter analysis (rodent)Normalized GABA turnover; ↑ serotonin and dopamine metabolism
BDNF expression studies in hippocampus↑ BDNF mRNA expression supporting neuroplasticity
Stress-induced immunosuppression modelsRestored interferon and cytokine balance; ↑ immune resilience
Cognitive performance tasks in healthy volunteers↑ attention, memory consolidation, and mental endurance
Enkephalin degradation assaysInhibition of enkephalin breakdown; prolonged endogenous opioid activity

Epithalon

Study / ModelReported effect
Human somatic cell culture↑ Telomerase activity, ↑ telomere length in dividing cells
Aged mice longevity studiesExtended median lifespan, ↓ age-related tumor incidence
Pineal gland animal modelsRestored melatonin secretion rhythm, normalized circadian markers
Elderly human observational cohortImproved sleep architecture, ↑ nocturnal melatonin levels
Retinal degeneration rat model↓ Photoreceptor loss, preserved retinal pigment epithelium
Oxidative stress in vitro assays↓ Lipid peroxidation, ↑ antioxidant enzyme expression
Immunosenescence rodent studiesRestored T-cell function, normalized thymic activity

Pinealon

Study / ModelReported effect
Aged rat cognitive performance↑ memory retention and learning capacity in Morris water maze tasks
Cultured cortical neurons (in vitro)↓ oxidative stress markers; ↑ neuronal survival under hypoxic conditions
Accelerated aging mouse model (SAMP1)Extended lifespan and preserved cognitive function compared to controls
Human fibroblast culture↑ telomerase activity and ↑ telomere length over multiple passages
Rotenone-induced neurotoxicity modelReduced apoptosis and preserved mitochondrial integrity in dopaminergic neurons
Elderly cognitive decline observational studyImproved attention, memory recall, and psycho-emotional state markers
Ischemia-reperfusion brain injury (rat)↓ infarct volume; ↑ neuroprotective gene expression including Bcl-2
Sleep-deprivation behavioral modelNormalized circadian markers and reduced stress-induced cognitive deficits

Glutathione

Study/modelReported effect
Human trials (oral and IV administration)

↑ Plasma GSH levels, ↓ oxidative biomarkers (MDA, 8-OHdG)

Animal oxidative stress models

↓ Lipid peroxidation and improved mitochondrial GSH:GSSG ratio

Hepatotoxicity models (CCl4, acetaminophen)

↓ ALT/AST, ↓ hepatic necrosis, improved antioxidant enzyme activity

Neurodegenerative disease models

Protection of dopaminergic neurons and ↓ oxidative stress markers

In vitro melanocyte cultures

↓ Tyrosinase activity and melanin synthesis via GSH-mediated inhibition

Inflammatory models

↓ TNF-α, IL-6, and CRP, supporting immunomodulatory roles

Pharmacokinetic assessments

↑ Cellular uptake with liposomal and SubQ formulations

Cortagen

Study / ModelReported effect
Aged rat cortical neuron cultures↑ neurite outgrowth and ↑ expression of neurotrophic markers
Rodent traumatic brain injury modelsAccelerated recovery of motor and cognitive function; ↓ neuroinflammatory markers
Aged rats (chronic administration)↑ learning and memory performance in maze-based tasks
In vitro fibroblast culturesNormalization of gene expression patterns associated with cellular aging
Geriatric human observational studiesReported improvements in cognitive performance, sleep quality, and mood in elderly subjects
Post-stroke rehabilitation observational research↑ recovery of higher cortical functions and ↓ asthenic symptoms
Cellular oxidative stress models↓ lipid peroxidation and ↑ endogenous antioxidant enzyme activity

Stack Suggestions​

This research bundle is designed for investigators focusing on advanced sleep cycle regulation, stress adaptation, and cellular aging mechanisms. It suits studies exploring complex peptide interactions for systemic balance and neurological function.

Pen Dosage Chart​

DSIP

DSIP Pen 5 mg
Volume2.0 mL (after reconstitution)
mg/mL2.5 mg/mL
Click-to-Dose1 click = 0.025 mg
Example(s)40 clicks = 1 mg; 80 clicks = 2 mg

Selank

Selank Pen 10 mg
Volume2.0 mL (after reconstitution)
mg/mL5.0 mg/mL
Click-to-Dose1 click = 0.05 mg
Example(s)30 clicks = 1.5 mg; 60 clicks = 3 mg

Epithalon

Epithalon Pen 20 mg
Volume2 mL
mg/mL10 mg/mL
Click-to-Dose1 click = 0.1 mg
Example(s)10 clicks = 1 mg

Pinealon

Pinealon Pen 20 mg
Volume2 mL
mg/mL10 mg/mL
Click-to-Dose1 click = 0.1 mg
Example(s)10 clicks = 1 mg

Glutathione

Glutathione Pen 1500 mg
Volume3 mL
mg/mL500 mg/mL
Click-to-Dose1 click = 5 mg
Example(s)10 clicks = 50 mg

Cortagen

Cortagen Pen 20 mg
Volume2 mL
mg/mL10 mg/mL
Click-to-Dose1 click = 0.1 mg
Example(s)10 clicks = 1 mg

Dosage & Protocols Variations​

DSIP

Standard Research Protocol

  • Dose: 0.1 – 0.3 mg (= 4–12 clicks)
  • Duration: 2 – 4 weeks
  • Frequency: Once daily, prior to rest phase
  • Cycle Interval: 2 weeks off before repeating
  • Goal / Description: Baseline protocol used in sleep architecture and circadian rhythm research models.

Therapeutic Research Protocol

  • Dose: 0.3 – 0.5 mg (= 12–20 clicks)
  • Duration: 3 – 5 weeks
  • Frequency: Daily, evening administration
  • Cycle Interval: 3 – 4 weeks off before repeating
  • Goal / Description: Higher-dose model for stress-response and neuroendocrine regulation studies.

Biohacker Protocol (experimental)

  • Dose: 0.05 – 0.1 mg (= 2–4 clicks)
  • Duration: 4 – 6 weeks
  • Frequency: Daily microdose before rest cycle
  • Cycle Interval: 1 – 2 weeks off before repeating
  • Goal / Description: Low-dose continuous exploration of sleep quality and recovery markers.

Selank

Standard Research Protocol

  • Dose: 0.25 – 0.5 mg (= 5–10 clicks)
  • Duration: 2 – 3 weeks
  • Frequency: Daily (SubQ)
  • Cycle Interval: 2 – 4 weeks off before repeating
  • Goal / Description: Baseline protocol for anxiolytic and cognitive stability models.

Therapeutic Research Protocol

  • Dose: 0.5 – 0.9 mg (= 10–18 clicks)
  • Duration: 3 – 4 weeks
  • Frequency: 2× daily, divided doses
  • Cycle Interval: 4 weeks off before repeating
  • Goal / Description: Higher-dose protocol used in stress-response and GABAergic modulation studies.

Biohacker Protocol (experimental)

  • Dose: 0.1 – 0.2 mg (= 2–4 clicks)
  • Duration: 4 – 6 weeks
  • Frequency: Daily microdose
  • Cycle Interval: 2 weeks off before repeating
  • Goal / Description: Low-dose continuous exposure for cognitive and mood-balance research.

Stacked Protocol (Selank + Semax)

  • Dose: 0.3 mg Selank + 0.3 mg Semax (= 6 clicks)
  • Duration: 2 – 3 weeks
  • Frequency: Daily
  • Cycle Interval: 3 – 4 weeks off before repeating
  • Goal / Description: Combined neuropeptide protocol for cognitive and anxiolytic research models.

Epithalon

Standard Research Protocol

  • Dose: 5 – 10 mg (= 50–100 clicks)
  • Duration: 2 – 3 weeks
  • Frequency: Daily
  • Cycle Interval: 4 – 6 months off before repeating
  • Goal / Description: Baseline protocol used in telomerase activation and cellular aging models.

Therapeutic Research Protocol

  • Dose: 10 – 20 mg (= 100–200 clicks)
  • Duration: 10 – 20 days
  • Frequency: Daily or split into two administrations
  • Cycle Interval: 3 – 6 months off before repeating
  • Goal / Description: Higher-dose schedule explored in longevity and pineal signaling research.

Biohacker Protocol (experimental)

  • Dose: 2 – 5 mg (= 20–50 clicks)
  • Duration: 4 – 6 weeks
  • Frequency: 5 days per week
  • Cycle Interval: 2 – 3 months off before repeating
  • Goal / Description: Microdose continuous approach in experimental aging models.

Pinealon

Standard Research Protocol

  • Dose: 1 – 3 mg
  • Duration: 2 – 4 weeks
  • Frequency: Daily
  • Cycle Interval: 4 – 8 weeks off before repeating
  • Goal / Description: Baseline protocol for neuroprotection and cognitive support models.

Therapeutic Research Protocol

  • Dose: 3 – 5 mg
  • Duration: 3 – 4 weeks
  • Frequency: Daily
  • Cycle Interval: 8 – 12 weeks off before repeating
  • Goal / Description: Higher-dose regimen used in studies targeting age-related cognitive decline and oxidative stress.

Biohacker Protocol (experimental)

  • Dose: 0.5 – 1 mg
  • Duration: 6 – 8 weeks
  • Frequency: 5× per week
  • Cycle Interval: 4 weeks off before repeating
  • Goal / Description: Low-dose continuous exposure for longevity and cellular preservation research.

Glutathione

Standard Antioxidant Protocol

  • Dose: 200 – 400 mg (= 40–80 clicks)
  • Duration: 4 – 8 weeks
  • Frequency: 3× weekly
  • Cycle Interval: 4-week rest
  • Goal / Description: ↑ Systemic antioxidant capacity, baseline redox support

Intensive Detoxification Protocol

  • Dose: 500 – 600 mg (= 100–120 clicks)
  • Duration: 4 weeks
  • Frequency: 5× weekly
  • Cycle Interval: 8-week rest
  • Goal / Description: Rapid ↑ GSH levels for detoxification models, tissue saturation

Maintenance Protocol

  • Dose: 150 mg (= 30 clicks)
  • Duration: 8 – 12 weeks
  • Frequency: 3× weekly
  • Cycle Interval: 8-week rest
  • Goal / Description: Long-term maintenance of improved GSH status

Cortagen

Standard Research Protocol

  • Dose: 1 – 2 mg
  • Duration: 10 – 20 days
  • Frequency: Daily
  • Cycle Interval: 4 – 6 months off before repeating
  • Goal / Description: Baseline protocol for connective tissue and joint research models.

Therapeutic Research Protocol

  • Dose: 2 – 4 mg
  • Duration: 15 – 30 days
  • Frequency: Daily
  • Cycle Interval: 3 – 6 months off before repeating
  • Goal / Description: Higher-dose protocol used in cartilage repair and post-injury recovery studies.

Biohacker Protocol (experimental)

  • Dose: 0.5 – 1 mg
  • Duration: 20 – 30 days
  • Frequency: 3 – 4× per week
  • Cycle Interval: 2 – 3 months off before repeating
  • Goal / Description: Microdose continuous exploration for long-term connective tissue maintenance.

Possible Side Effects​

DSIP

DSIP is generally well-tolerated in animal and limited human research studies.

Reported side effects are infrequent and mild:

  • Mild headache or dizziness following administration.
  • Transient drowsiness or grogginess upon waking.
  • Localized irritation at the injection site.
  • Occasional changes in dream intensity or vividness.

No evidence of hormonal, hepatic, or cardiovascular adverse effects has been observed in available data.

Selank

Selank is generally well-tolerated in animal and limited human clinical studies, with no significant adverse effects reported at standard research doses.

Reported observations include:

  • Mild transient drowsiness or fatigue during initial dosing.
  • Occasional headache or lightheadedness in sensitive subjects.
  • Localized irritation or redness at the injection site.
  • Rare reports of mild nasal discomfort with intranasal administration.

Unlike classical anxiolytics, Selank has not been observed to produce sedation, dependence, withdrawal, or cognitive impairment in available research data. No evidence of hormonal, hepatic, or cardiovascular adverse effects has been documented.

Epithalon

Epithalon is generally well-tolerated in preclinical and limited human observational studies.

Reported side effects are rare and typically mild:

  • Transient drowsiness or mild fatigue following administration.
  • Localized irritation, redness, or tenderness at injection site.
  • Occasional mild headache during initial dosing periods.
  • Temporary changes in sleep patterns linked to pineal signaling modulation.

No evidence of hormonal, hepatic, or systemic adverse effects has been observed in available research data.

Pinealon

Pinealon is generally well-tolerated in animal studies and limited human observational research.

Reported side effects are infrequent and mild:

  • Transient mild headache during initial dosing.
  • Localized irritation or redness at injection site.
  • Occasional drowsiness or altered sleep patterns.
  • Mild gastrointestinal discomfort in sensitive subjects.

No evidence of hormonal, hepatic, or neurotoxic adverse effects has been observed in available preclinical data. As a short tripeptide, Pinealon is rapidly metabolized into its constituent amino acids, which contributes to its favorable tolerability profile in experimental models.

Glutathione

Glutathione supplementation is generally well-tolerated due to its endogenous nature, but some individuals may experience side effects, particularly with higher doses or sensitive constitutions. The most common adverse reactions are related to gastrointestinal adjustments and administration site responses with subcutaneous injection protocols.

Gastrointestinal Effects: Mild nausea, abdominal cramping, bloating, and flatulence may occur, especially during the initial supplementation period. These symptoms typically resolve as the body adapts to increased glutathione levels. Some users report a metallic or sulfur-like taste, which is attributed to the cysteine component of the molecule.

Injection Site Reactions: With subcutaneous administration, mild redness, swelling, or irritation at the injection site may occur. These reactions are typically transient and resolve within 24-48 hours. Proper injection technique and site rotation can minimize these effects.

Allergic Reactions: Although rare, some individuals may experience allergic responses including skin rashes, hives, or in severe cases, difficulty breathing. Those with known sensitivities to sulfur-containing compounds should exercise particular caution.

Respiratory Considerations: Individuals with asthma or respiratory sensitivities should avoid inhaled forms, as glutathione may trigger bronchospasms or respiratory distress in predisposed individuals.

Headaches and Fatigue: Some users report mild headaches or temporary fatigue during initial supplementation, likely related to detoxification processes and cellular adjustments to enhanced antioxidant capacity.

It is important to note that most side effects are mild, transient, and resolve with continued use or dosage adjustment. However, individuals should discontinue use and consult healthcare providers if adverse reactions persist or worsen.

Cortagen

Cortagen is generally well-tolerated in preclinical and limited human observational studies.

Reported side effects are rare and mild:

  • Localized redness or transient discomfort at the injection site.
  • Mild drowsiness or fatigue during initial dosing.
  • Occasional headache or lightheadedness in sensitive subjects.
  • Transient changes in sleep patterns reported in early research models.

No evidence of hormonal, hepatic, or systemic adverse effects has been observed in available data.

Product Attributes​

Scientific References​

DSIP

Selank

Epithalon

Pinealon

Glutathione

Cortagen

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