Melanotan I - Pigmentation Signaling & UV Response Modulator
Description
Melanotan I (Afamelanotide) is a synthetic analog of alpha-melanocyte stimulating hormone designed to selectively activate melanocortin-1 receptors (MC1R) expressed on melanocytes. MC1R activation regulates eumelanin production, influencing pigmentation and photoprotective responses. Compared to other melanocortin agonists, Melanotan I demonstrates higher receptor selectivity, primarily targeting pigmentation pathways rather than broader melanocortin system activation.
Our formulation is provided in a stabilized pre-mixed injection pen for SubQ administration. Subcutaneous delivery supports controlled systemic exposure and predictable receptor engagement in experimental protocols. Each unit is freshly prepared to preserve peptide integrity and standardized dosing. The product is intended strictly for laboratory and research use only.
In research models, Melanotan I has been observed to stimulate melanogenesis through activation of cyclic AMP signaling within melanocytes. This intracellular signaling cascade influences tyrosinase activity and melanin synthesis. Research domains include pigmentation biology, UV response modulation, erythropoietic protoporphyria studies, and photoprotection research contexts.
Clinical Status
Human RCT ✔ | Observational ✔ | Animal ✔ | In vitro ✔
Clinically evaluated and approved in certain jurisdictions for specific photoprotection indications.
Mechanism of Action
Melanotan I activates melanocortin-1 receptors (MC1R) on melanocytes, stimulating intracellular signaling pathways that increase melanin production. This results in enhanced eumelanin synthesis and increased skin pigmentation in research models. The peptide mimics endogenous alpha-MSH but with improved stability and receptor selectivity.
Benefits
- Selective activation of melanocortin-1 receptors:
Melanotan I has been studied for its selective activation of MC1R receptors located on melanocytes. These receptors regulate pigmentation signaling pathways responsible for eumelanin synthesis. By preferentially targeting MC1R, Melanotan I limits broader activation of other melanocortin receptor subtypes. This receptor specificity supports focused pigmentation research without extensive systemic melanocortin engagement. - Stimulation of eumelanin synthesis:
Activation of intracellular cAMP signaling increases transcription of genes involved in melanin production. Upregulation of MITF enhances expression of tyrosinase, a key enzyme in the melanin synthesis pathway. Eumelanin production contributes to darker pigmentation and increased photoprotective capacity in experimental models. This biochemical pathway underlies its role in pigmentation research. - Modulation of ultraviolet response pathways:
Melanin serves as a natural photoprotective pigment by absorbing and dissipating ultraviolet radiation. Research demonstrates enhanced pigmentation response following administration in controlled settings. Increased eumelanin content may influence UV-induced DNA damage models in laboratory research. These photobiological properties position Melanotan I within dermatologic and photoprotection studies. - Enhanced stability compared to endogenous alpha-MSH:
Native alpha-MSH is rapidly degraded in circulation. Melanotan I incorporates structural modifications that improve resistance to enzymatic breakdown. This enhanced stability allows more sustained receptor engagement in research settings. The improved pharmacokinetic profile supports controlled experimental protocols. - Dermatologic research applications:
Melanotan I has been evaluated in clinical research involving pigmentation disorders and light sensitivity conditions. Its ability to increase eumelanin content supports investigation into protective pigmentation responses. These studies contribute to understanding melanocortin pathway biology in human populations. - Predictable subcutaneous pharmacokinetics:
Provided in a stabilized pre-mixed injection pen for SubQ administration, Melanotan I supports consistent systemic exposure in experimental settings. Subcutaneous delivery allows structured dosing parameters and reproducible receptor engagement. Each unit is freshly prepared and intended strictly for laboratory use only.
Research Data
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Pen Dosage Chart
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Product Attributes
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Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 7°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS cold-chain transport boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not support merchants in this field.
For this reason, we accept bank transfers only.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day (cut-off dependent).
This method ensures compliance, security, and continuity of service for all customers across the EU.
