KPV - Targeted Inflammation Control & Gut Barrier Support
Description
KPV is a C-terminal tripeptide fragment of alpha-MSH that retains selective anti-inflammatory properties independent of full melanocortin receptor activation. It has been studied for its ability to modulate pro-inflammatory cytokine production and influence NF-kB–mediated signaling pathways. Unlike broader melanocortin agonists, KPV appears to exert localized immune-regulatory effects with reduced systemic melanocortin activity.
Our formulation is provided in a stabilized pre-mixed injection pen for SubQ administration. Subcutaneous delivery supports controlled systemic exposure and predictable immunomodulatory signaling in experimental protocols. Each unit is freshly prepared to preserve peptide integrity and standardized dosing. The product is intended strictly for laboratory and research use only.
In preclinical models, KPV has been observed to influence tumor necrosis factor-alpha signaling, interleukin expression, and epithelial barrier function. Research domains include inflammatory bowel models, dermatologic inflammation research, and cytokine modulation investigations.
Clinical Status
Human RCT ▣ | Observational ▣ | Animal ▣ | In vitro ✔
Primarily studied in inflammatory modulation and epithelial barrier research contexts.
Mechanism of Action
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Benefits
- Helps calm overactive inflammatory responses:
KPV is studied for its ability to help regulate inflammatory signaling when the immune system becomes overly reactive. Instead of shutting down immune activity completely, it appears to support a more balanced response. This is important because excessive inflammation can disrupt normal tissue function. In laboratory models, KPV has been associated with reduced levels of certain pro-inflammatory messengers. The goal of this signaling shift is not immune suppression, but improved regulation. This makes KPV relevant in research focused on chronic or localized inflammation. - Supports gut lining integrity and barrier stability:
The intestinal barrier plays a critical role in separating the external environment from internal immune signaling. When this barrier becomes compromised, inflammatory processes can escalate. KPV has been studied in experimental gut inflammation models where improved epithelial stability was observed. Research suggests it may influence tight junction proteins that help maintain structural integrity of the gut lining. By supporting barrier resilience, KPV is often explored in gastrointestinal research contexts. - Encourages balanced cytokine signaling:
Cytokines are chemical messengers that control immune communication. When certain cytokines are overproduced, inflammatory cycles can become self-sustaining. KPV has been evaluated for its influence on regulating key inflammatory mediators. Rather than eliminating these signals, it appears to help moderate their intensity. This fine-tuning approach supports immune balance instead of blunt suppression. - Studied in inflammatory skin models:
Inflammation is not limited to internal tissues; the skin is also a highly active immune organ. KPV has been explored in dermatologic research models involving inflammatory signaling in keratinocytes. Reduced inflammatory marker expression has been observed in controlled laboratory settings. This expands its relevance beyond gastrointestinal research into broader epithelial biology. - Promotes a more controlled immune environment:
A healthy immune response requires precision. Too little activation increases vulnerability, while too much can damage tissue. KPV is studied for its role in helping maintain this balance. Its effects appear localized and regulatory rather than system-wide suppression. This makes it an interesting candidate in research examining immune recalibration rather than immune shutdown. - Derived from a natural anti-inflammatory sequence:
KPV originates from the alpha-MSH peptide, which is naturally involved in anti-inflammatory signaling in the body. As a small fragment, it retains certain regulatory properties without activating the entire melanocortin system. This selective behavior allows researchers to study focused inflammatory modulation without broader hormonal effects. - Explored in models of chronic low-grade inflammation:
Chronic low-level inflammation is increasingly studied in metabolic and barrier-related conditions. KPV has been evaluated in experimental systems that simulate prolonged inflammatory stress. Findings suggest it may help reduce excessive immune signaling in these contexts. Its small size and targeted activity profile support investigation in localized inflammatory environments. - Designed for structured research use:
Provided in a stabilized pre-mixed injection pen for SubQ administration, KPV supports controlled experimental exposure. Subcutaneous delivery allows consistent absorption in research protocols. Each unit is freshly prepared and intended strictly for laboratory use only.
Research Data
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Stack Suggestions
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Pen Dosage Chart
Dosage & Protocols Variations
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Possible Side Effects
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Product Attributes
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Scientific References
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Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 7°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS cold-chain transport boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not support merchants in this field.
For this reason, we accept bank transfers only.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day (cut-off dependent).
This method ensures compliance, security, and continuity of service for all customers across the EU.
