Semax - Cognitive Signaling & Neuroprotection Peptide
Description
Semax is a synthetic heptapeptide derived from the ACTH (4-10) fragment, modified to enhance stability and biological activity. It belongs to the class of neuroactive regulatory peptides and is primarily studied in domains such as cognitive function, neuroprotection, stroke recovery models, and stress-related neurobiology. Unlike full ACTH, Semax does not stimulate corticosteroid production, allowing selective neurological signaling research. In experimental models, it has been observed to influence neurotrophic factor expression and neurotransmitter balance.
Our formulation is provided in a stabilized pre-mixed injection pen for SubQ administration. Subcutaneous delivery supports reliable systemic absorption and consistent experimental exposure. Each unit is freshly prepared to preserve peptide stability and ensure standardized dosing within research protocols. This format eliminates multi-step reconstitution and simplifies laboratory handling. The product is formulated strictly for research use only.
In research models, Semax has been observed to increase expression of brain-derived neurotrophic factor (BDNF) and modulate monoaminergic systems including dopamine and serotonin pathways. Preclinical studies demonstrate improved neuronal survival and synaptic plasticity under stress conditions. Clinical research in neurological models has explored its effects on cognitive performance and recovery signaling. Evidence type: Human clinical studies ✔ | Animal ▣ | In vitro ▣.
Clinical Status
Human RCT ▣ | Observational ✔ | Animal ✔ | In vitro ✔
Studied in cognitive and neuroprotective research settings, including regional clinical applications.
Mechanism of Action
Semax modulates neurotrophic signaling and monoaminergic neurotransmission through selective activation of gene expression pathways associated with neuronal survival and plasticity. In research models, it has been observed to increase brain-derived neurotrophic factor (BDNF) levels → ↑ synaptic plasticity and neuronal resilience. Unlike full ACTH, Semax does not stimulate corticosteroid production, allowing targeted neurological effects without endocrine overstimulation. Preclinical and human studies suggest modulation of dopamine and serotonin pathways, contributing to cognitive signaling balance. These mechanisms support its positioning in neuroplasticity and cognitive resilience research.
Benefits
- Upregulation Of Neurotrophic Factors:
Semax has been studied for its ability to increase expression of brain-derived neurotrophic factor (BDNF) in both animal and human neurological research. BDNF plays a central role in synaptic plasticity, dendritic spine formation, and neuronal survival. Research demonstrates ↑ BDNF mRNA and protein levels in hippocampal regions following administration. This effect supports enhanced neuronal connectivity in experimental learning models. Neurotrophic activation is considered one of the core mechanisms underlying its cognitive research profile. Evidence type: Human clinical studies ✔ | Animal ▣. - Enhanced Synaptic Plasticity And Memory Signaling:
Clinical studies have evaluated Semax in cognitive impairment and attentional performance models. Improvements in memory recall and executive function scores have been documented in controlled settings. Mechanistically, ↑ CREB activation contributes to long-term potentiation processes within hippocampal circuits. Preclinical data show improved synaptic density under stress conditions. These findings support its role in experimental neuroplasticity enhancement. - Modulation Of Dopamine And Serotonin Systems:
Semax has been observed to influence monoaminergic neurotransmission, particularly dopamine and serotonin turnover. Laboratory studies indicate regulation of transporter activity and receptor sensitivity in cortical regions. This modulation contributes to balanced neurotransmitter signaling in stress-related research models. Improved attentional performance metrics have been associated with this pathway in human studies. Evidence type: Human ✔ | Animal ▣. - Neuroprotection Under Ischemic And Oxidative Stress Conditions:
In ischemic animal models, Semax administration has been associated with ↓ infarct volume and improved behavioral recovery scores. Research demonstrates ↓ glutamate excitotoxicity and ↓ oxidative stress biomarkers in neuronal tissue. Enhanced neuronal survival pathways have been documented through BDNF-mediated signaling. These effects position Semax within experimental stroke and neuroprotection research domains. - Gene Expression Regulation And Anti-Inflammatory Modulation:
Gene expression profiling studies show modulation of inflammatory cytokines and stress-response proteins following Semax exposure. Research indicates ↓ expression of certain pro-inflammatory mediators in brain tissue models. This regulatory influence contributes to a stabilized neuronal microenvironment. Evidence remains primarily preclinical with supporting clinical observations. - Cognitive Resilience In Stress Models:
Semax has been studied in models of acute and chronic stress exposure. Behavioral testing demonstrates improved performance compared to control groups under stress conditions. Mechanistic hypotheses suggest stabilization of monoamine signaling and neurotrophic pathways. These findings support inclusion in cognitive resilience research. - Selective ACTH Fragment Without Cortisol Stimulation:
Unlike full ACTH peptides, Semax does not significantly stimulate adrenal corticosteroid production. This selective activity allows neurological pathway modulation without systemic endocrine activation. Clinical endocrine markers confirm absence of significant cortisol elevation in controlled studies. - High Bioavailability Through Subcutaneous Administration:
Provided in a stabilized pre-mixed injection pen for SubQ administration, ensuring consistent systemic exposure in research protocols. Subcutaneous delivery supports reliable peptide absorption and simplifies laboratory handling. Each unit is freshly prepared and intended strictly for research use only.
Research Data
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Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 7°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS cold-chain transport boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not support merchants in this field.
For this reason, we accept bank transfers only.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day (cut-off dependent).
This method ensures compliance, security, and continuity of service for all customers across the EU.
