NAD+
Price range: $283.20 through $423.60
NAD+ Cellular Energy & Mitochondrial Support
Description
Nicotinamide Adenine Dinucleotide (NAD+) is a pyridine nucleotide coenzyme central to redox reactions, mitochondrial respiration, and cellular signaling. It exists in two forms — oxidized (NAD⁺) and reduced (NADH) — both indispensable for ATP generation and metabolic homeostasis. NAD+ serves as a cofactor for hundreds of oxidoreductase enzymes, enabling the conversion of nutrients into energy through the Krebs and electron transport chains.
In addition to its role in metabolism, NAD+ functions as a substrate for sirtuins and PARPs, proteins involved in DNA repair, inflammation control, and gene expression regulation. These processes make NAD+ a central molecule in aging, neuroprotection, and metabolic research.
Formulated in a stabilized pre-mixed injection pen for SubQ administration, our NAD+ preparation ensures high systemic bioavailability and consistent plasma concentration in controlled settings. This delivery model bypasses gastrointestinal degradation, providing an ideal format for advanced cellular and mitochondrial studies.
Clinical Status:
NAD+ is an endogenous coenzyme studied extensively in human and preclinical trials. Injectable and intravenous NAD+ preparations are used in experimental metabolic and neurocognitive research, but not approved for therapeutic purposes.
Evidence type:
Human RCT ✔ | Observational ✔ | Animal ✔ | In vitro ✔ | Regulatory ☐
Mechanism of Action
NAD+ participates in glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation, transferring electrons to complex I of the electron transport chain to produce ATP. It is also consumed by PARP enzymes in DNA repair and by sirtuins, which deacetylate transcription factors like PGC-1α and FOXO3a. These actions enhance mitochondrial biogenesis, stress resistance, and genomic stability. In cellular aging models, replenishing NAD+ restores NAD⁺/NADH ratio, activates AMPK signaling, and reduces oxidative and inflammatory burden through downstream modulation of NF-κB and mTOR pathways.
Benefits
- Essential Cofactor for Cellular Energy Production:
NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme required for ATP synthesis and mitochondrial respiration. It facilitates the transfer of electrons in redox reactions within the Krebs cycle and electron transport chain. Research consistently demonstrates that maintaining optimal NAD+ levels is essential for energy metabolism, cellular vitality, and mitochondrial function. - Support for Mitochondrial Function and Bioenergetics:
NAD+ plays a central role in mitochondrial maintenance and oxidative phosphorylation. It supports the conversion of nutrients into cellular energy and helps preserve mitochondrial DNA integrity. Restoration of NAD+ levels in experimental models enhances ATP production, improves cellular endurance, and delays mitochondrial dysfunction associated with aging and metabolic decline. - Activation of Sirtuins and Longevity Pathways:
As a required cofactor for sirtuin enzyme activation (SIRT1-SIRT7), NAD+ directly influences gene expression related to metabolism, stress resistance, and aging. Sirtuins regulate DNA repair, inflammatory balance, and mitochondrial biogenesis. Increasing NAD+ availability has been shown to extend lifespan and healthspan in multiple preclinical models. - Improved DNA Repair and Cellular Resilience:
NAD+ is the substrate for PARP (Poly ADP-Ribose Polymerase), an enzyme responsible for repairing DNA damage. Adequate NAD+ levels enable efficient DNA repair, genomic stability, and cell survival following oxidative or environmental stress. This mechanism is central to ongoing research on longevity, genoprotection, and anti-aging strategies. - Enhancement of Cognitive Function and Neuroprotection:
Research suggests that increasing NAD+ availability enhances neuronal energy metabolism and reduces neuroinflammation. By supporting mitochondrial function within neurons, NAD+ helps protect against cognitive decline, memory impairment, and neurodegenerative damage, making it a cornerstone in studies of brain health and aging. - Reduction of Inflammation and Oxidative Stress:
Through the regulation of sirtuin and PARP activity, NAD+ modulates the expression of pro-inflammatory cytokines such as TNF-α and IL-6. This results in improved redox balance and reduced cellular inflammation, supporting tissue recovery, immune balance, and overall systemic homeostasis in metabolic and aging research. - Improved Metabolic Efficiency and Insulin Sensitivity:
Experimental data show that higher NAD+ levels enhance glucose and lipid metabolism by activating AMPK and sirtuin pathways. This leads to improved insulin sensitivity, better mitochondrial oxidation, and stable energy utilization, making it valuable in research exploring obesity, metabolic syndrome, and type 2 diabetes. - Support for Muscle Endurance and Physical Performance:
NAD+ is essential for muscle cell energy turnover and endurance. Studies demonstrate that replenishment of NAD+ improves mitochondrial density and oxidative capacity in skeletal muscle, resulting in better exercise performance, faster recovery, and resistance to fatigue in both animal and human research models. - Maintenance of Liver and Cardiometabolic Health:
NAD+ replenishment has been shown to improve lipid metabolism and reduce hepatic fat accumulation. It supports mitochondrial β-oxidation, reduces oxidative stress in liver cells, and promotes vascular function, making it a central focus in studies on fatty liver disease and cardiovascular protection. - Restoration of Circadian Rhythm and Cellular Homeostasis:
NAD+ levels oscillate with circadian rhythm and regulate the activity of clock-controlled genes. Maintaining sufficient NAD+ availability aligns metabolic and cellular processes with biological day-night cycles, promoting hormonal balance, improved sleep patterns, and optimized cellular repair in experimental circadian studies. - Synergy with Mitochondrial Peptides and Antioxidants:
When combined with peptides such as MOTS-c, SS-31, or 5-Amino-1MQ, NAD+ amplifies mitochondrial biogenesis, antioxidant defense, and energy metabolism. This synergistic interaction supports experimental longevity models and highlights its importance as a universal cofactor in advanced metabolic optimization research. - Potential in Longevity and Anti-Aging Research:
Declining NAD+ levels are a hallmark of aging, and replenishment has been observed to restore youthful cellular function in preclinical models. Its influence on mitochondrial health, DNA repair, inflammation, and sirtuin activation collectively positions NAD+ as one of the most important molecules under study for lifespan and healthspan extension.
Research Data
| Study/model | Reported effect |
| Human clinical trials (IV NAD+ administration) |
↑ plasma NAD+ by 4-6×; improved fatigue and alertness scores
|
| Animal models (aged mice) |
Restored mitochondrial function and ↑ lifespan by 15-20%
|
| Cellular aging models |
Activation of SIRT1 and PARP1 → enhanced DNA repair and mitochondrial biogenesis
|
| Human observational studies |
Correlation between low NAD+ and metabolic dysfunction, insulin resistance
|
| In vitro neuronal cultures |
Protection from oxidative and excitotoxic stress; improved neurite outgrowth
|
| Metabolic disorder models |
↓ triglycerides and hepatic steatosis via AMPK activation
|
| Exercise recovery studies |
↑ muscle NAD+/NADH ratio and improved endurance performance
|
| Brain ischemia models |
↓ infarct size and enhanced neuronal survival post-injury
|
Stack Suggestions
NAD is commonly combined with:
- SS-31 (mitochondrial antioxidant, deeper repair synergy)
- Glutathione (detoxification, redox balance)
- BPC-157 (recovery & repair, tissue regeneration)
- Epitalon (anti-aging, telomere function)
- NMN/NR (NAD precursor loading for enhanced effect)
Stacks discussed are for experimental design only, not safety/efficacy guidance.
Pen Dosage Chart
| NAD+ Pen 500 mg | |
| Volume | 3.0 mL |
| mg/mL | 166 mg/mL |
| Click-to-Dose | 1 click = 1.66 mg |
| Example(s) | 30 clicks = 50 mg |
| NAD+ Pen 1000 mg | |
| Volume | 3.0 mL |
| mg/mL | 333 mg/mL |
| Click-to-Dose | 1 click = 3.33 mg |
| Example(s) | 15 clicks = 50 mg |
Dosage & Protocols Variations
Standard Cellular Support
- Dose: 50 – 100 mg
- Duration: 8 – 12 weeks
- Frequency: Every Other Day
- Cycle Interval: 4-week rest
- Goal / Description: Common research design for mitochondrial and energy studies
Intensive Regeneration Protocol
- Dose: 100 – 250 mg
- Duration: 8 – 12 weeks
- Frequency: 1× daily
- Cycle Interval: 8-week rest
- Goal / Description: Applied in models focusing on recovery and DNA repair
Neurocognitive Focus Protocol
- Dose: 50 mg
- Duration: 8 – 12 weeks
- Frequency: 1× daily (morning)
- Cycle Interval: 4-week rest
- Goal / Description: Studied for neuronal resilience and alertness optimization
Longevity & Metabolic Protocol
- Dose: 50 – 150 mg
- Duration: 8 – 12 weeks
- Frequency: Every Other Day
- Cycle Interval: 8-week rest
- Goal / Description: Designed for long-term metabolic and aging research
Possible Side Effects
NAD+, as a research coenzyme boosting metabolism, may induce mild side effects in experimental models, primarily during initial administration. These are dose-dependent and often transient. It’s crucial to monitor for subcutaneous reactions.
Headache: Commonly observed at higher doses, manifesting as mild pressure, linked to vascular changes. It typically resolves within days.
Nausea: Occasional gastrointestinal upset, especially with rapid escalation. Frequency decreases with slower protocols.
Dizziness: Lightheadedness reported early on, possibly from energy shifts. Resolves as models adapt.
Flushing: Warm sensation or skin redness, attributed to niacin-like effects.
Fatigue: Paradoxical tiredness initially, due to metabolic adjustments.
Most side effects are minor and manageable through dose titration. Prolonged exposure warrants vigilance for rare issues like hypersensitivity, though uncommon in controlled settings.
Product Attributes
- CAS #: 53-84-9
- Molecular Formula: C21H27N7O14P2
- Sequence (AA): N/A (coenzyme, not peptide)
- Molecular Weight: 663.43 g/mol
- PubChem CID: 5893
- Half-Life: ~1 – 2 hours (systemic)
- Synonyms: Nicotinamide Adenine Dinucleotide, β-NAD+, NADH oxidized form, , (Diphosphopyridine )
- Type: Endogenous coenzyme involved in energy metabolism and repair
- Research Focus: Mitochondria & Anti-Age Research
Scientific References
- NAD+ therapy in age-related degenerative disorders: A benefit/risk … Review
- The efficacy and safety of β-nicotinamide mononucleotide (NMN … Human RCT
- NAD + Supplementation Normalizes Key Alzheimer’s Features and … Animal
- Effect of Nicotinamide Adenine Dinucleotide on Heart Failure … Review
- Nicotinamide riboside Induced Energy Stress and Metabolic … Animal
- Oral nicotinamide riboside raises NAD+ and lowers biomarkers of … Human RCT
- Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with … Review
- safety, insulin-sensitivity, and lipid-mobilizing effects – PubMedHuman RCT
- NAD+ Metabolism in Cardiac Health, Aging, and Disease – PubMed Review
- NAD + -boosting molecules suppress mast cell degranulation and … Animal
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 7°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS cold-chain transport boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not support merchants in this field.
For this reason, we accept bank transfers only.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day (cut-off dependent).
This method ensures compliance, security, and continuity of service for all customers across the EU.
