Longevity – Advanced
Building on the Start kit, Longevity Advanced adds the vascular bioregulator Vesugen, the pineal bioregulator Pinealon and the master antioxidant Glutathione for a broader six-peptide approach to aging research. Together they let investigators probe telomere maintenance, immune and vascular regulation, redox balance and NAD metabolism in parallel.
Supplied at research-grade purity. For research purposes only; not for human consumption.
El precio original era: 525,00 €.394,00 €El precio actual es: 394,00 €.
El panel completo de longevidad — Epithalon, Thymalin, NAD+, Vesugen, Pinealon y Glutathione para la investigación del envejecimiento multisistémico.
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Longevity - Advanced - Advanced Research for Cellular Longevity Pathways
Epithalon peptide studies
Thymalin peptide investigations
NAD+ coenzyme research
Vesugen peptide exploration
Pinealon peptide studies
Glutathione compound research
Epithalon peptide research
NAD+ pathway investigation
Description
Mechanism of Action
This advanced research stack explores multifaceted longevity pathways. Epithalon and Pinealon investigate telomere support and neuroendocrine regulation. Thymalin focuses on immune system modulation. NAD+ research examines cellular energy metabolism. Vesugen explores vascular integrity, and Glutathione investigates critical antioxidant defense, offering a comprehensive approach to understanding age-related cellular and systemic functions.
Benefits
- Cellular Senescence Research – Epithalon’s telomere support.
- Immune System Modulation – Thymalin’s regulatory role.
- Metabolic Energy Pathways – NAD+ investigation.
- Vascular Health Exploration – Vesugen’s peptide research.
- Neurocognitive Support Studies – Pinealon’s brain peptide.
- Oxidative Stress Defense – Glutathione’s antioxidant properties.
Research Data
Epithalon
| Study / Model | Reported effect |
|---|---|
| Human somatic cell culture | ↑ Telomerase activity, ↑ telomere length in dividing cells |
| Aged mice longevity studies | Extended median lifespan, ↓ age-related tumor incidence |
| Pineal gland animal models | Restored melatonin secretion rhythm, normalized circadian markers |
| Elderly human observational cohort | Improved sleep architecture, ↑ nocturnal melatonin levels |
| Retinal degeneration rat model | ↓ Photoreceptor loss, preserved retinal pigment epithelium |
| Oxidative stress in vitro assays | ↓ Lipid peroxidation, ↑ antioxidant enzyme expression |
| Immunosenescence rodent studies | Restored T-cell function, normalized thymic activity |
Thymalin
| Study / Model | Reported effect |
|---|---|
| Aged murine models | ↑ thymic cellularity, ↑ CD4+/CD8+ ratio, restored T-cell output |
| Immunocompromised rodent studies | ↑ IL-2 and interferon-gamma expression, improved lymphocyte proliferation |
| Elderly human observational cohorts | Reduced incidence of respiratory infections and improved immune markers |
| Radiation-exposure animal models | Accelerated hematopoietic recovery and lymphocyte regeneration |
| Chronic inflammation models | ↓ pro-inflammatory cytokines (TNF-α, IL-6), normalized immune balance |
| In vitro thymocyte cultures | Enhanced T-cell maturation and differentiation signaling |
| Geriatric clinical observations | Improved telomerase activity and extended cellular longevity markers |
NAD+
| Study/model | Reported effect |
| Human clinical trials (IV NAD+ administration) | ↑ plasma NAD+ by 4-6×; improved fatigue and alertness scores |
| Animal models (aged mice) | Restored mitochondrial function and ↑ lifespan by 15-20% |
| Cellular aging models | Activation of SIRT1 and PARP1 → enhanced DNA repair and mitochondrial biogenesis |
| Human observational studies | Correlation between low NAD+ and metabolic dysfunction, insulin resistance |
| In vitro neuronal cultures | Protection from oxidative and excitotoxic stress; improved neurite outgrowth |
| Metabolic disorder models | ↓ triglycerides and hepatic steatosis via AMPK activation |
| Exercise recovery studies | ↑ muscle NAD+/NADH ratio and improved endurance performance |
| Brain ischemia models | ↓ infarct size and enhanced neuronal survival post-injury |
Vesugen
| Study / Model | Reported effect |
|---|---|
| Aged rat vascular tissue | ↑ endothelial regeneration markers; improved capillary density |
| Human umbilical vein endothelial cell (HUVEC) culture | ↑ proliferation rate and ↓ senescence-associated markers |
| Atherosclerosis animal model | ↓ plaque progression; improved vascular wall integrity |
| Elderly cohort observational study | Improved microcirculation and reduced markers of vascular aging |
| In vitro telomere assay | Telomerase activity preservation in endothelial lineages |
| Hypertensive rat model | ↓ systolic pressure; ↑ nitric oxide bioavailability |
| Diabetic vascular complication model | Reduced endothelial dysfunction and oxidative stress markers |
Pinealon
| Study / Model | Reported effect |
|---|---|
| Aged rat cognitive performance | ↑ memory retention and learning capacity in Morris water maze tasks |
| Cultured cortical neurons (in vitro) | ↓ oxidative stress markers; ↑ neuronal survival under hypoxic conditions |
| Accelerated aging mouse model (SAMP1) | Extended lifespan and preserved cognitive function compared to controls |
| Human fibroblast culture | ↑ telomerase activity and ↑ telomere length over multiple passages |
| Rotenone-induced neurotoxicity model | Reduced apoptosis and preserved mitochondrial integrity in dopaminergic neurons |
| Elderly cognitive decline observational study | Improved attention, memory recall, and psycho-emotional state markers |
| Ischemia-reperfusion brain injury (rat) | ↓ infarct volume; ↑ neuroprotective gene expression including Bcl-2 |
| Sleep-deprivation behavioral model | Normalized circadian markers and reduced stress-induced cognitive deficits |
Glutathione
| Study/model | Reported effect |
| Human trials (oral and IV administration) | ↑ Plasma GSH levels, ↓ oxidative biomarkers (MDA, 8-OHdG) |
| Animal oxidative stress models | ↓ Lipid peroxidation and improved mitochondrial GSH:GSSG ratio |
| Hepatotoxicity models (CCl4, acetaminophen) | ↓ ALT/AST, ↓ hepatic necrosis, improved antioxidant enzyme activity |
| Neurodegenerative disease models | Protection of dopaminergic neurons and ↓ oxidative stress markers |
| In vitro melanocyte cultures | ↓ Tyrosinase activity and melanin synthesis via GSH-mediated inhibition |
| Inflammatory models | ↓ TNF-α, IL-6, and CRP, supporting immunomodulatory roles |
| Pharmacokinetic assessments | ↑ Cellular uptake with liposomal and SubQ formulations |
Stack Suggestions
This research bundle is designed for investigators exploring advanced, multi-faceted longevity pathways. It suits those interested in the synergistic effects of peptides and coenzymes on cellular health, immune function, and neuroprotection within a research context.
Pen Dosage Chart
Epithalon
| Epithalon Pen 20 mg | |
|---|---|
| Volume | 2 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.1 mg |
| Example(s) | 10 clicks = 1 mg |
Thymalin
| Thymalin Pen 20 mg | |
| Volume | 2 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.1 mg |
| Example(s) | 10 clicks = 1 mg |
NAD+
| NAD+ Pen 500 mg | |
| Volume | 3.0 mL |
| mg/mL | 166.67 mg/mL |
| Click-to-Dose | 1 click = 1.67 mg |
| Example(s) | 30 clicks = 50 mg |
| NAD+ Pen 1000 mg | |
| Volume | 3.0 mL |
| mg/mL | 333.33 mg/mL |
| Click-to-Dose | 1 click = 3.33 mg |
| Example(s) | 15 clicks = 50 mg |
Vesugen
| Vesugen Pen 20 mg | |
| Volume | 2 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.1 mg |
| Example(s) | 10 clicks = 1 mg |
Pinealon
| Pinealon Pen 20 mg | |
| Volume | 2 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.1 mg |
| Example(s) | 10 clicks = 1 mg |
Glutathione
| Glutathione Pen 1500 mg | |
|---|---|
| Volume | 3 mL |
| mg/mL | 500 mg/mL |
| Click-to-Dose | 1 click = 5 mg |
| Example(s) | 10 clicks = 50 mg |
Dosage & Protocols Variations
Epithalon
Standard Research Protocol
- Dose: 5 – 10 mg (= 50–100 clicks)
- Duration: 2 – 3 weeks
- Frequency: Daily
- Cycle Interval: 4 – 6 months off before repeating
- Goal / Description: Baseline protocol used in telomerase activation and cellular aging models.
Therapeutic Research Protocol
- Dose: 10 – 20 mg (= 100–200 clicks)
- Duration: 10 – 20 days
- Frequency: Daily or split into two administrations
- Cycle Interval: 3 – 6 months off before repeating
- Goal / Description: Higher-dose schedule explored in longevity and pineal signaling research.
Biohacker Protocol (experimental)
- Dose: 2 – 5 mg (= 20–50 clicks)
- Duration: 4 – 6 weeks
- Frequency: 5 days per week
- Cycle Interval: 2 – 3 months off before repeating
- Goal / Description: Microdose continuous approach in experimental aging models.
Thymalin
Standard Research Protocol
- Dose: 5 – 10 mg
- Duration: 5 – 10 days
- Frequency: Daily intramuscular administration
- Cycle Interval: 4 – 6 months before repeating
- Goal / Description: Baseline immunomodulatory protocol used in aging and immune restoration models.
Therapeutic Research Protocol
- Dose: 10 – 20 mg
- Duration: 10 – 14 days
- Frequency: Daily
- Cycle Interval: 3 – 6 months off before repeating
- Goal / Description: Higher-dose protocol applied in immunocompromised and chronic inflammation models.
Biohacker Protocol (experimental)
- Dose: 2 – 5 mg
- Duration: 10 – 20 days
- Frequency: Every other day
- Cycle Interval: 2 – 3 times per year
- Goal / Description: Low-dose longevity-oriented schedule explored in epigenetic and thymic regeneration research.
NAD+
Standard Cellular Support
- Dose: 50 – 100 mg (variant 500 mg pen = 30–60 clicks / variant 1000 mg pen = 15–30 clicks)
- Duration: 8 – 12 weeks
- Frequency: Every Other Day
- Cycle Interval: 4-week rest
- Goal / Description: Common research design for mitochondrial and energy studies
Intensive Regeneration Protocol
- Dose: 100 – 250 mg (variant 500 mg pen = 60–150 clicks / variant 1000 mg pen = 30–75 clicks)
- Duration: 8 – 12 weeks
- Frequency: 1× daily
- Cycle Interval: 8-week rest
- Goal / Description: Applied in models focusing on recovery and DNA repair
Neurocognitive Focus Protocol
- Dose: 50 mg (variant 500 mg pen = 30 clicks / variant 1000 mg pen = 15 clicks)
- Duration: 8 – 12 weeks
- Frequency: 1× daily (morning)
- Cycle Interval: 4-week rest
- Goal / Description: Studied for neuronal resilience and alertness optimization
Longevity & Metabolic Protocol
- Dose: 50 – 150 mg (variant 500 mg pen = 30–90 clicks / variant 1000 mg pen = 15–45 clicks)
- Duration: 8 – 12 weeks
- Frequency: Every Other Day
- Cycle Interval: 8-week rest
- Goal / Description: Designed for long-term metabolic and aging research
Vesugen
Standard Research Protocol
- Dose: 100 – 200 mcg
- Duration: 4 – 6 weeks
- Frequency: Daily, sublingual or SubQ
- Cycle Interval: 4 – 8 weeks off before repeating
- Goal / Description: Baseline protocol for vascular function and endothelial integrity studies.
Therapeutic Research Protocol
- Dose: 200 – 400 mcg
- Duration: 6 – 8 weeks
- Frequency: Daily
- Cycle Interval: 8 weeks off before repeating
- Goal / Description: Extended protocol used in models targeting vascular aging and microcirculation.
Biohacker Protocol (experimental)
- Dose: 50 – 100 mcg
- Duration: 8 – 12 weeks
- Frequency: Daily, low-dose sublingual
- Cycle Interval: Continuous with 2-week pauses every 12 weeks
- Goal / Description: Microdose approach explored in longevity-oriented vascular research.
Pinealon
Standard Research Protocol
- Dose: 1 – 3 mg
- Duration: 2 – 4 weeks
- Frequency: Daily
- Cycle Interval: 4 – 8 weeks off before repeating
- Goal / Description: Baseline protocol for neuroprotection and cognitive support models.
Therapeutic Research Protocol
- Dose: 3 – 5 mg
- Duration: 3 – 4 weeks
- Frequency: Daily
- Cycle Interval: 8 – 12 weeks off before repeating
- Goal / Description: Higher-dose regimen used in studies targeting age-related cognitive decline and oxidative stress.
Biohacker Protocol (experimental)
- Dose: 0.5 – 1 mg
- Duration: 6 – 8 weeks
- Frequency: 5× per week
- Cycle Interval: 4 weeks off before repeating
- Goal / Description: Low-dose continuous exposure for longevity and cellular preservation research.
Glutathione
Standard Antioxidant Protocol
- Dose: 200 – 400 mg (= 40–80 clicks)
- Duration: 4 – 8 weeks
- Frequency: 3× weekly
- Cycle Interval: 4-week rest
- Goal / Description: ↑ Systemic antioxidant capacity, baseline redox support
Intensive Detoxification Protocol
- Dose: 500 – 600 mg (= 100–120 clicks)
- Duration: 4 weeks
- Frequency: 5× weekly
- Cycle Interval: 8-week rest
- Goal / Description: Rapid ↑ GSH levels for detoxification models, tissue saturation
Maintenance Protocol
- Dose: 150 mg (= 30 clicks)
- Duration: 8 – 12 weeks
- Frequency: 3× weekly
- Cycle Interval: 8-week rest
- Goal / Description: Long-term maintenance of improved GSH status
Possible Side Effects
Epithalon
Epithalon is generally well-tolerated in preclinical and limited human observational studies.
Reported side effects are rare and typically mild:
- Transient drowsiness or mild fatigue following administration.
- Localized irritation, redness, or tenderness at injection site.
- Occasional mild headache during initial dosing periods.
- Temporary changes in sleep patterns linked to pineal signaling modulation.
No evidence of hormonal, hepatic, or systemic adverse effects has been observed in available research data.
Thymalin
Thymalin is generally well-tolerated in clinical and preclinical studies involving elderly and immunocompromised populations.
Reported side effects are infrequent and mild:
- Transient redness or mild swelling at the injection site.
- Occasional low-grade fever during initial dosing in immunocompromised models.
- Mild fatigue or drowsiness reported in early administration phases.
- Rare allergic-type reactions in sensitive subjects.
No evidence of hepatic, endocrine, or systemic toxicity has been observed in available research data.
NAD+
NAD+, as a research coenzyme boosting metabolism, may induce mild side effects in experimental models, primarily during initial administration. These are dose-dependent and often transient. It’s crucial to monitor for subcutaneous reactions.
Headache: Commonly observed at higher doses, manifesting as mild pressure, linked to vascular changes. It typically resolves within days.
Nausea: Occasional gastrointestinal upset, especially with rapid escalation. Frequency decreases with slower protocols.
Dizziness: Lightheadedness reported early on, possibly from energy shifts. Resolves as models adapt.
Flushing: Warm sensation or skin redness, attributed to niacin-like effects.
Fatigue: Paradoxical tiredness initially, due to metabolic adjustments.
Most side effects are minor and manageable through dose titration. Prolonged exposure warrants vigilance for rare issues like hypersensitivity, though uncommon in controlled settings.
Vesugen
Vesugen is generally well-tolerated in preclinical and limited observational studies.
Reported side effects are rare and mild:
- Mild localized irritation at the injection site.
- Transient headache during initial dosing periods.
- Occasional digestive sensitivity in sensitive subjects.
- Slight fatigue reported in early observational use.
No evidence of hormonal, hepatic, or systemic adverse effects has been observed in available research data. As a short tripeptide bioregulator, Vesugen is structurally similar to endogenous peptide fragments, which is associated with its low reported toxicity profile in experimental models.
Pinealon
Pinealon is generally well-tolerated in animal studies and limited human observational research.
Reported side effects are infrequent and mild:
- Transient mild headache during initial dosing.
- Localized irritation or redness at injection site.
- Occasional drowsiness or altered sleep patterns.
- Mild gastrointestinal discomfort in sensitive subjects.
No evidence of hormonal, hepatic, or neurotoxic adverse effects has been observed in available preclinical data. As a short tripeptide, Pinealon is rapidly metabolized into its constituent amino acids, which contributes to its favorable tolerability profile in experimental models.
Glutathione
Glutathione supplementation is generally well-tolerated due to its endogenous nature, but some individuals may experience side effects, particularly with higher doses or sensitive constitutions. The most common adverse reactions are related to gastrointestinal adjustments and administration site responses with subcutaneous injection protocols.
Gastrointestinal Effects: Mild nausea, abdominal cramping, bloating, and flatulence may occur, especially during the initial supplementation period. These symptoms typically resolve as the body adapts to increased glutathione levels. Some users report a metallic or sulfur-like taste, which is attributed to the cysteine component of the molecule.
Injection Site Reactions: With subcutaneous administration, mild redness, swelling, or irritation at the injection site may occur. These reactions are typically transient and resolve within 24-48 hours. Proper injection technique and site rotation can minimize these effects.
Allergic Reactions: Although rare, some individuals may experience allergic responses including skin rashes, hives, or in severe cases, difficulty breathing. Those with known sensitivities to sulfur-containing compounds should exercise particular caution.
Respiratory Considerations: Individuals with asthma or respiratory sensitivities should avoid inhaled forms, as glutathione may trigger bronchospasms or respiratory distress in predisposed individuals.
Headaches and Fatigue: Some users report mild headaches or temporary fatigue during initial supplementation, likely related to detoxification processes and cellular adjustments to enhanced antioxidant capacity.
It is important to note that most side effects are mild, transient, and resolve with continued use or dosage adjustment. However, individuals should discontinue use and consult healthcare providers if adverse reactions persist or worsen.
Product Attributes
Scientific References
Epithalon
- Peptide promotes overcoming of the division limit in human somatic cell In vitro
- Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells In vitro
- Inhibition of development of spontaneous mammary tumors in mice by Epithalon Animal
- Effect of Epithalon on biomarkers of aging, life span and spontaneous tumor incidence in female rats Animal
- Pineal peptide preparation Epithalamin and tetrapeptide Epitalon: results of clinical use in humans Observational
- Peptides and aging: relevance to cancer prevention and longevity research Animal | In vitro
- Epithalon and aging: experimental and clinical perspectives Observational | Animal
- Telomerase activation and senescence pathways in peptide research In vitro
Thymalin
- Thymalin: clinical-experimental investigation in elderly and aged patients Observational | Animal
- Khavinson VK. Peptides and ageing Observational | Animal
- Anti-inflammatory and anti-aging effects of thymic peptide bioregulators in COVID-19 elderly patients Observational
- Peptide regulation of cell differentiation and gene expression in aging Animal | In vitro
- Short peptides and telomere length regulator hormone irisin: a novel approach to age-related diseases Observational | In vitro
- Effect of thymalin on the immune system and lifespan of mice Animal
- Peptide bioregulators: a novel direction of preventive gerontology Observational | Animal
- Influence of thymalin on functional activity of immune cells in patients with acute pneumonia Observational
NAD+
- NAD+ therapy in age-related degenerative disorders: A benefit/risk … Review
- The efficacy and safety of β-nicotinamide mononucleotide (NMN … Human RCT
- NAD + Supplementation Normalizes Key Alzheimer’s Features and … Animal
- Effect of Nicotinamide Adenine Dinucleotide on Heart Failure … Review
- Nicotinamide riboside Induced Energy Stress and Metabolic … Animal
- Oral nicotinamide riboside raises NAD+ and lowers biomarkers of … Human RCT
- Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with … Review
- safety, insulin-sensitivity, and lipid-mobilizing effects – PubMedHuman RCT
- NAD+ Metabolism in Cardiac Health, Aging, and Disease – PubMed Review
- NAD + -boosting molecules suppress mast cell degranulation and … Animal
Vesugen
- Vascular wall peptide bioregulator prevents the H2O2-induced damage of endothelial cells Animal | In vitro
- Peptide KED: molecular-genetic aspects of neuroendocrine system regulation in aging In vitro
- Short peptides stimulate cell regeneration suppressed in elderly after stress exposure Animal | In vitro
- Peptidergic regulation of cell differentiation in 3D cell cultures In vitro
- Tripeptide KED induces vasoprotective and antioxidant gene expression in vascular endothelium In vitro
- Short peptides and telomere length regulator hTERT gene expression In vitro
- Geroprotective effects of short peptides in aging vascular research models Observational | Animal
- Molecular aspects of peptide bioregulation in vascular and endothelial tissue Observational | In vitro
Pinealon
- Short peptides stimulate cell regeneration in skin during aging Animal | In vitro
- Peptide regulation of cell differentiation Animal | In vitro
- Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging Animal | In vitro
- Tripeptides restore the number of neuronal spines under conditions of in vitro modeled Alzheimer’s disease In vitro
- Pinealon enhances resistance of cells of cerebral cortex of rat embryos to oxidative stress Animal | In vitro
- Peptidergic regulation of cell proliferation and renewal during aging Observational | Animal
- Neuroprotective effects of peptide bioregulators in experimental models of neurodegeneration Animal | In vitro
Glutathione
- Randomized controlled trial of oral glutathione supplementation on body stores of glutathione Human RCT
- Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function Human RCT
- Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression Animal
- Glutathione system enhancement for cardiac protection: pharmacological and clinical data from bench-to-bedside Observational
- Randomized clinical trial of how long-term glutathione supplementation improves lipid metabolism in obese patients with nonalcoholic fatty liver disease Human RCT
- ALSUntangled no. 52: glutathione Human RCT
- Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, clinical trial Human observational
- Systemic glutathione as a skin-whitening agent in adults Human RCT
- Clinical evaluation of glutathione concentrations after consumption of S-acetylglutathione: a pilot study Human observational
- Development of a mouse model expressing a bifunctional glutathione-synthesizing enzyme to study glutathione limitation in vivo Animal
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Almacenamiento
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