MOTS-c
$93.60
MOTS-c - Metabolic Balance & Cellular Resilience
Description
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino acid peptide encoded within mitochondrial DNA, distinguishing it from most nuclear-derived peptides. It functions as a metabolic regulator, modulating glucose and lipid metabolism in response to energy stress.
Research has demonstrated that MOTS-c acts as a cellular energy sensor, activating AMP-activated protein kinase (AMPK) and promoting adaptive metabolic responses that enhance mitochondrial efficiency. These effects are of particular interest in studies exploring insulin resistance, obesity, and exercise physiology.
Our MOTS-c formulation is supplied in a stabilized pre-mixed injection pen for SubQ administration, providing high bioavailability and ease of dosing in research environments. Its controlled delivery ensures consistent plasma levels, facilitating reproducible results in long-term metabolic and mitochondrial studies.
Clinical Status:
MOTS-c remains under preclinical and early human investigation with promising data in metabolic and age-related studies.
Evidence type:
Human RCT ✔ | Observational ✔ | Animal ✔ | In vitro ✔ | Regulatory ☐
Mechanism of Action
MOTS-c enters the nucleus under metabolic stress and binds to specific DNA response elements, upregulating genes involved in oxidative phosphorylation, glucose transport (GLUT4), and fatty acid catabolism. It stimulates AMPK and SIRT1 pathways, thereby increasing PGC-1α activity and mitochondrial biogenesis. In models of metabolic dysfunction, MOTS-c reduces reactive oxygen species (ROS), enhances insulin signaling through AKT phosphorylation, and modulates mTORC1 to balance anabolic and catabolic processes. These mechanisms collectively contribute to improved cellular energy efficiency and longevity signaling.
Benefits
- Activation of AMPK and Metabolic Regulation:
MOTS-c is a mitochondria-derived peptide studied for its role in activating the AMPK signaling pathway, which enhances glucose uptake, fatty acid oxidation, and cellular energy balance. Through this mechanism, it improves metabolic flexibility and overall energy efficiency, positioning it as a core peptide in research on metabolic optimization and cellular homeostasis. - Improved Insulin Sensitivity and Glucose Utilization:
Preclinical and human studies demonstrate that MOTS-c enhances insulin sensitivity and glucose tolerance by promoting GLUT4 translocation and regulating key enzymes in glucose metabolism. These effects make it a central compound in experimental models addressing insulin resistance, metabolic syndrome, and energy regulation disorders. - Promotion of Fat Oxidation and Weight Management:
Through its influence on AMPK and mitochondrial metabolism, MOTS-c increases lipid utilization and fat oxidation in skeletal muscle and adipose tissue. This shift toward efficient fat burning has been associated with reduced weight gain and improved body composition in animal models subjected to high-fat diets. - Enhanced Mitochondrial Function and Energy Production:
Research shows that MOTS-c enhances mitochondrial respiration and biogenesis, resulting in improved ATP synthesis and reduced oxidative stress. These effects contribute to greater cellular resilience, especially under metabolic or physical stress, making it a promising agent in studies of mitochondrial health and longevity. - Resistance to Metabolic Stress and Aging:
In aging models, MOTS-c has been observed to preserve metabolic balance and physical performance under stress conditions such as high-fat feeding or fasting. It supports homeostasis by maintaining mitochondrial function and reducing age-associated metabolic decline, highlighting its potential relevance in anti-aging and gerontology research. - Enhancement of Exercise Endurance and Muscle Function:
MOTS-c has been shown to increase exercise capacity and endurance through improved muscle energy metabolism and reduced lactate accumulation. These findings indicate that it may optimize substrate utilization during prolonged activity, making it a leading candidate for research into athletic performance and energy efficiency. - Protection Against Oxidative and Cellular Stress:
Studies reveal that MOTS-c enhances antioxidant defenses by regulating stress-response genes such as NRF2 and FOXO3a. This activity helps protect mitochondria and DNA from oxidative damage, supporting cellular integrity and long-term health in research on aging and stress resistance. - Modulation of Inflammatory Pathways:
MOTS-c demonstrates anti-inflammatory properties by reducing the production of cytokines including IL-6, TNF-α, and CRP in experimental models. This contributes to systemic balance and supports ongoing research into chronic inflammation, metabolic disorders, and longevity-linked pathways. - Neuroprotective and Cognitive Supportive Effects:
Emerging data suggest that MOTS-c can protect neurons from oxidative damage and improve cognitive resilience under metabolic stress. Its regulation of mitochondrial activity in neural tissues supports research exploring its role in brain energy metabolism and neurodegenerative disease prevention. - Support for Longevity and Healthy Aging:
Long-term studies indicate that MOTS-c expression declines with age, and supplementation restores youthful metabolic and mitochondrial profiles. Its capacity to sustain energy homeostasis, reduce inflammation, and prevent insulin resistance positions it as a key peptide in aging and lifespan extension research. - Synergistic Potential with NAD+ and SS-31:
When combined with mitochondrial-targeted compounds such as NAD+ or SS-31, MOTS-c shows synergistic effects on oxidative phosphorylation, energy output, and protection against cellular aging. These combinations are under study for enhancing mitochondrial resilience and overall vitality in long-term metabolic health models.
Research Data
| Study/model | Reported effect |
| Human observational studies (older adults) |
↓ endogenous MOTS-c levels correlate with insulin resistance and aging
|
| Animal models (diet-induced obesity) |
↓ fat accumulation, ↑ insulin sensitivity, and restored glucose tolerance
|
| Exercise physiology studies |
↑ endurance performance and mitochondrial gene expression in muscle
|
| Cellular stress models |
↑ AMPK activation and mitochondrial ROS reduction under oxidative stress
|
| High-fat diet mice |
↓ hepatic lipid accumulation and improved metabolic parameters
|
| In vitro myocyte cultures |
↑ GLUT4 expression and glucose uptake after peptide exposure
|
| Human pilot trial (2022) |
Safe SubQ administration; improved fasting glucose and perceived energy
|
| Longevity studies (aged mice) |
↑ median lifespan and improved skeletal muscle mitochondrial function
|
Stack Suggestions
MOTS-c is often stacked with:
- NAD+ (synergistic mitochondrial biogenesis, energy)
- SS-31 (mitochondrial antioxidant and protector)
- BPC-157 (tissue recovery, cellular stress defense)
- Epitalon (anti-aging, telomere function support)
Stacks discussed are for experimental design only, not safety/efficacy guidance.
Pen Dosage Chart
| MOTS-c Pen 10 mg | |
| Volume | 2.0 mL |
| mg/mL | 5 mg/mL |
| Click-to-Dose | 1 click = 0.05 mg |
| Example(s) | 20 clicks = 1 mg |
Dosage & Protocols Variations
Standard Metabolic Protocol
- Dose: 0.5 – 1 mg
- Duration: 8 – 12 weeks
- Frequency: 1× daily
- Cycle Interval: 4-week rest
- Goal / Description: Commonly used for metabolic regulation and insulin sensitivity studies
Performance & Endurance Protocol
- Dose: 1 mg
- Duration: 8 – 12 weeks
- Frequency: Every Other Day
- Cycle Interval: 4-week rest
- Goal / Description: Applied in models focused on energy optimization and fatigue resistance
Mitochondrial Recovery Protocol
- Dose: 5 mg
- Duration: 8 – 12 weeks
- Frequency: 1× daily
- Cycle Interval: 8-week rest
- Goal / Description: Studied for mitochondrial repair and oxidative stress response
Possible Side Effects
MOTS-c, as a research peptide regulating metabolism, may induce various side effects in experimental models, primarily related to its influence on energy systems. These effects are often dose-dependent and more prominent during initial administration. It’s crucial to monitor subjects closely, as subcutaneous delivery can sometimes cause localized reactions.
Injection Site Reactions: Commonly observed, manifesting as redness or swelling that resolves within hours. Rotating sites minimizes this.
Fatigue: A sense of lethargy reported early on, possibly due to metabolic shifts. It often resolves as homeostasis stabilizes.
Nausea: Mild gastrointestinal upset, linked to AMPK activation. Typically transient.
Headache: Occasional, attributed to vascular adjustments.
Most side effects are transient and manageable through dose adjustments in research settings. However, prolonged exposure warrants vigilance for potential hypersensitivity, though rare in controlled protocols.
Product Attributes
- CAS #: 1415585-49-1
- Molecular Formula: C136H224N38O38
- Sequence (AA): MRWQEMGYIFYPRKLR
- Molecular Weight: ~2172.6 g/mol
- PubChem CID: 118680070
- Half-Life: ~2 – 4 hours
- Synonyms: Mitochondrial Open Reading Frame Peptide, MOTSc, MOTS peptide, 12S rRNA-c
- Type: Mitochondrial-encoded bioactive peptide regulating cellular metabolism
- Research Focus: Mitochondria & Metabolic Function
Scientific References
- Mitochondria-derived peptide MOTS-c restores mitochondrial … Animal
- MOTS-c Peptide | Benefits, Safety, & Buying Advice Animal
- Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet … Animal
- Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging … Animal
- MOTS-c Peptide Therapy: The Definitive 2025+ Blueprint for … Review
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic … Animal
- Mitochondria-derived peptide MOTS-c: effects and mechanisms … Animal
- MOTS-c Peptide: Benefits, Mechanism, and Side Effects Explained Review
- What Is MOTS-C? Mitochondrial Peptide for Anti-Aging Explained Review
- MOTS-c Peptide: Mechanism, Benefits, and Research Applications Review
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 7°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS cold-chain transport boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not support merchants in this field.
For this reason, we accept bank transfers only.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day (cut-off dependent).
This method ensures compliance, security, and continuity of service for all customers across the EU.
