{"id":43671,"date":"2026-10-07T22:24:07","date_gmt":"2026-10-07T22:24:07","guid":{"rendered":"https:\/\/peptidepowereu.is\/?post_type=product&#038;p=43671"},"modified":"2026-10-07T22:26:32","modified_gmt":"2026-10-07T22:26:32","slug":"pnc-27","status":"publish","type":"product","link":"https:\/\/peptidepowereu.is\/ro\/pnc-27\/","title":{"rendered":"PNC-27"},"content":{"rendered":"<p><strong>PNC-27<\/strong> este o <strong>peptid\u0103 sintetic\u0103 himeric\u0103<\/strong> compus\u0103 dintr-un segment de 15 reziduuri din <strong>domeniul de legare HDM-2 (MDM2) al p53 (reziduurile 12-26)<\/strong> fuzionat cu o peptid\u0103 de reziden\u021b\u0103 membranar\u0103 (MRP) derivat\u0103 din penetratin. Acest design structural este studiat in vitro pentru interac\u021biunea sa cu HDM-2 asociat membranei \u0219i pentru influen\u021ba sa asupra organiz\u0103rii bistratului lipidic \u00een linii celulare cultivate care exprim\u0103 HDM-2 la membrana plasmatic\u0103.<\/p>\n<p>\u00cen cercet\u0103ri experimentale in vitro, PNC-27 a fost observat c\u0103 <strong>interac\u021bioneaz\u0103 cu membrana plasmatic\u0103<\/strong> a liniilor celulare cultivate care prezint\u0103 HDM-2 la suprafa\u021ba membranei, unde segmentul MRP ancoreaz\u0103 peptida \u0219i sus\u021bine <strong>formarea de pori transmembranari<\/strong>. Studiile au caracterizat aceste interac\u021biuni membranare \u00een mai multe modele de linii celulare cultivate.<\/p>\n<p>Investiga\u021biile mecanistice au explorat, de asemenea, influen\u021ba PNC-27 asupra <strong>organiz\u0103rii colesterolului membranar<\/strong> \u0219i comportamentul s\u0103u conforma\u021bional la interfe\u021bele lipidice, diferen\u021biind designul s\u0103u de reziden\u021b\u0103 membranar\u0103 de peptidele clasice intracelulare derivate din p53.<\/p>\n<p>Furnizat sub form\u0103 de <strong>pen injectabil gata de utilizare<\/strong> (solu\u021bie de 2 mL, 1 clic = 0,01 mL) la <strong>puritate &gt;98% HPLC<\/strong>, PNC-27 este destinat exclusiv manipul\u0103rii \u00een laborator \u0219i analizelor in vitro; nu este publicat niciun protocol de dozare pentru cercetare \u0219i nu se recomand\u0103 nicio doz\u0103 (vezi sec\u021biunea de dozare).<\/p>\n<p><strong>Statut clinic:<\/strong><br \/>\nPNC-27 este o <strong>peptid\u0103 de cercetare<\/strong> investigat\u0103 exclusiv \u00een studii preclinice in vitro privind legarea HDM-2 \u0219i formarea porilor membranari. Nu este aprobat\u0103 pentru uz medical \u0219i r\u0103m\u00e2ne restric\u021bionat\u0103 la <strong>cercetare de laborator \u0219i experimental\u0103<\/strong>.<\/p>\n<p><strong>Tip de dovezi:<\/strong><br \/>\nStudiu clinic \u2610 | Observa\u021bional \u2610 | Animal \u2714 | In vitro \u2714 | Reglementare \u2610<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PNC-27 este o peptid\u0103 sintetic\u0103 himeric\u0103 compus\u0103 dintr-un segment de 15 reziduuri din domeniul de legare HDM-2 (MDM2) al p53<\/p>\n","protected":false},"featured_media":43685,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[341],"product_tag":[],"class_list":["post-43671","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-aging-longevity-research","first","instock","shipping-taxable","purchasable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product\/43671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":1,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product\/43671\/revisions"}],"predecessor-version":[{"id":43709,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product\/43671\/revisions\/43709"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/media\/43685"}],"wp:attachment":[{"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/media?parent=43671"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product_brand?post=43671"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product_cat?post=43671"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product_tag?post=43671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}