{"id":43573,"date":"2026-10-07T22:19:19","date_gmt":"2026-10-07T22:19:19","guid":{"rendered":"https:\/\/peptidepowereu.is\/?post_type=product&#038;p=43573"},"modified":"2026-10-07T22:21:34","modified_gmt":"2026-10-07T22:21:34","slug":"hep-1","status":"publish","type":"product","link":"https:\/\/peptidepowereu.is\/ro\/hep-1\/","title":{"rendered":"HEP-1"},"content":{"rendered":"<p><strong>HEP-1<\/strong> este o <strong>peptid\u0103 sintetic\u0103 format\u0103 din 14 aminoacizi<\/strong>, derivat\u0103 din <strong>fragmentul 324-337 al ezrinei umane<\/strong>, o protein\u0103 citoscheletal\u0103 implicat\u0103 \u00een leg\u0103tura membran\u0103-citoschelet \u0219i \u00een semnalizarea intracelular\u0103. Este investigat\u0103 \u00een principal pentru <strong>activitatea sa imunomodulatoare<\/strong>, modelele de cercetare explor\u00e2nd efectele asupra echilibrului citokinelor, semnaliz\u0103rii interferonilor \u0219i r\u0103spunsurilor imune mucoase.<\/p>\n<p>\u00cen sistemele experimentale, s-a raportat c\u0103 HEP-1 <strong>moduleaz\u0103 profilurile de citokine Th1\/Th2<\/strong>, influen\u021beaz\u0103 <strong>semnalizarea interferonilor<\/strong> \u0219i sus\u021bine <strong>activitatea macrofagelor \u0219i a celulelor NK<\/strong>. Cercet\u0103rile pe modele celulare \u0219i animale au observat <strong>restabilirea r\u0103spunsurilor imune afectate<\/strong> \u00een condi\u021bii de imunosupresie, \u00eempreun\u0103 cu modularea mediatorilor inflamatori la nivelul suprafe\u021belor mucoase.<\/p>\n<p>Investiga\u021biile secundare au examinat HEP-1 \u00een contextul <strong>diferen\u021bierii fibroblastelor<\/strong> (Chulkina 2017) \u0219i al <strong>inflama\u021biei mucoase<\/strong> \u00een <strong>modelul murin de colit\u0103 indus\u0103 cu DSS<\/strong> (Chulkina 2020), cu efecte observate asupra activ\u0103rii imune locale \u00een modelele de cercetare gastrointestinal\u0103. Aceste rezultate au stimulat interesul fa\u021b\u0103 de peptidele derivate din ezrin\u0103 ca poten\u021biali candida\u021bi pentru studierea modul\u0103rii imune direc\u021bionate asupra gazdei.<\/p>\n<p>Furnizat\u0103 ca <strong>pen injector gata de utilizare<\/strong> (solu\u021bie de 2 mL, 1 clic = 0,01 mL), cu <strong>puritate HPLC &gt;98%<\/strong>, HEP-1 este formulat\u0103 pentru <strong>administrare subcutanat\u0103 \u00een scop de cercetare<\/strong>, cu dozare precis\u0103 bazat\u0103 pe clicuri. Dimensiunea sa redus\u0103 \u0219i secven\u021ba definit\u0103 o fac potrivit\u0103 pentru dozare controlat\u0103 \u00een cercetarea imunologic\u0103 <strong>in vitro<\/strong> \u0219i <strong>in vivo<\/strong>.<\/p>\n<p><strong>Status clinic:<\/strong><br \/>\nHEP-1 este o <strong>peptid\u0103 de cercetare<\/strong> evaluat\u0103 \u00een culturi celulare \u0219i modele animale pentru activitatea imunomodulatoare \u0219i cercetarea imunit\u0103\u021bii mucoase. De\u0219i preparate \u00eenrudite derivate din ezrin\u0103 au fost studiate \u00een contexte observa\u021bionale umane \u00een str\u0103in\u0103tate, HEP-1 nu este aprobat\u0103 pentru uz medical \u0219i r\u0103m\u00e2ne restric\u021bionat\u0103 la <strong>cercetarea experimental\u0103 \u0219i de laborator<\/strong>.<\/p>\n<p><strong>Tip de dovezi:<\/strong><br \/>\nStudiu clinic \u2610 | Observa\u021bional \u2714 | Animal \u2714 | In vitro \u2714 | Reglementare \u2610<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HEP-1 este o peptid\u0103 sintetic\u0103 format\u0103 din 14 aminoacizi, derivat\u0103 din fragmentul 324-337 al ezrinei umane, o protein\u0103 citoscheletal\u0103 implicat\u0103<\/p>\n","protected":false},"featured_media":43587,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[342,343],"product_tag":[],"class_list":["post-43573","product","type-product","status-publish","has-post-thumbnail","product_cat-immunity-inflammation-research","product_cat-recovery-regeneration-research","first","instock","shipping-taxable","purchasable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product\/43573","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":1,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product\/43573\/revisions"}],"predecessor-version":[{"id":43611,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product\/43573\/revisions\/43611"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/media\/43587"}],"wp:attachment":[{"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/media?parent=43573"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product_brand?post=43573"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product_cat?post=43573"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/peptidepowereu.is\/ro\/wp-json\/wp\/v2\/product_tag?post=43573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}