{"id":39157,"date":"2026-06-21T10:23:15","date_gmt":"2026-06-21T10:23:15","guid":{"rendered":"https:\/\/peptidepowereu.is\/?post_type=product&#038;p=39157"},"modified":"2026-06-21T11:04:18","modified_gmt":"2026-06-21T11:04:18","slug":"p21-p021","status":"publish","type":"product","link":"https:\/\/peptidepowereu.is\/it\/p21-p021\/","title":{"rendered":"P21 (P021)"},"content":{"rendered":"<p><strong>P21<\/strong> is a synthetic <strong>tetrapeptide<\/strong> derived from <strong>ciliary neurotrophic factor (CNTF)<\/strong>, engineered to retain the <strong>neurogenic and neurotrophic activity<\/strong> of the parent molecule while crossing the <strong>blood-brain barrier<\/strong>. It is investigated for its ability to support <strong>adult neurogenesis<\/strong>, <strong>synaptic plasticity<\/strong>, and <strong>cognitive function<\/strong> in experimental models of neurodegeneration.<\/p>\n<p>In preclinical research, P21 has been observed to <strong>stimulate hippocampal neurogenesis<\/strong>, <strong>enhance BDNF expression<\/strong>, and <strong>reduce tau hyperphosphorylation<\/strong> through modulation of <strong>leukemia inhibitory factor receptor (LIFR)<\/strong> signaling and downstream <strong>JAK\/STAT pathways<\/strong>. These mechanisms have been linked with improvements in <strong>spatial memory<\/strong>, <strong>learning capacity<\/strong>, and <strong>neuronal survival<\/strong> in rodent models of Alzheimer&#8217;s disease and Down syndrome.<\/p>\n<p>Additional studies suggest P21 may exert <strong>neuroprotective effects<\/strong> against amyloid-beta toxicity and age-related synaptic decline, supporting its role as a candidate compound in <strong>cognitive aging research<\/strong> and <strong>neurodegenerative disease modeling<\/strong>.<\/p>\n<p>Formulated as a <strong>lyophilized powder<\/strong> for reconstitution, P21 is supplied for <strong>subcutaneous or intranasal administration<\/strong> in controlled laboratory settings, offering stable handling and precise experimental dosing.<\/p>\n<p><strong>Clinical Status:<\/strong><br \/>\nP21 is a <strong>research peptide<\/strong> evaluated exclusively in preclinical animal and in vitro studies focused on neurogenesis, synaptic plasticity, and cognitive decline. It is not approved for medical use and remains restricted to <strong>experimental and laboratory research<\/strong>.<\/p>\n<p><strong>Evidence type:<\/strong><br \/>\nHuman RCT \u2610 | Observational \u2610 | Animal \u2714 | In vitro \u2714 | Regulatory \u2610<\/p>\n","protected":false},"excerpt":{"rendered":"<p>P21 is a synthetic tetrapeptide derived from ciliary neurotrophic factor (CNTF), engineered to retain the neurogenic and neurotrophic activity of<\/p>\n","protected":false},"featured_media":39560,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[513],"product_tag":[],"class_list":["post-39157","product","type-product","status-publish","has-post-thumbnail","product_cat-nootropics-cognitive-function-research","first","instock","shipping-taxable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/peptidepowereu.is\/it\/wp-json\/wp\/v2\/product\/39157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptidepowereu.is\/it\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/peptidepowereu.is\/it\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":1,"href":"https:\/\/peptidepowereu.is\/it\/wp-json\/wp\/v2\/product\/39157\/revisions"}],"predecessor-version":[{"id":39561,"href":"https:\/\/peptidepowereu.is\/it\/wp-json\/wp\/v2\/product\/39157\/revisions\/39561"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peptidepowereu.is\/it\/wp-json\/wp\/v2\/media\/39560"}],"wp:attachment":[{"href":"https:\/\/peptidepowereu.is\/it\/wp-json\/wp\/v2\/media?parent=39157"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/peptidepowereu.is\/it\/wp-json\/wp\/v2\/product_brand?post=39157"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/peptidepowereu.is\/it\/wp-json\/wp\/v2\/product_cat?post=39157"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/peptidepowereu.is\/it\/wp-json\/wp\/v2\/product_tag?post=39157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}