GHRP-2
$46.80
GHRP-2 - Potent Growth Hormone Release & Anabolic Signaling
Description
GHRP-2 is a synthetic ghrelin mimetic peptide belonging to the growth hormone releasing peptide family. It binds to the growth hormone secretagogue receptor (GHS-R1a), stimulating pulsatile release of growth hormone from the anterior pituitary. Compared to GHRP-6, GHRP-2 is generally considered more potent in stimulating GH secretion with relatively reduced appetite stimulation.
In preclinical and exploratory human research, GHRP-2 has been studied for its ability to increase circulating growth hormone and influence downstream IGF-1 signaling. Activation of ghrelin receptors in the hypothalamus and pituitary integrates endocrine output with metabolic regulation pathways.
Clinical Status
Human RCT ▣ | Observational ▣ | Animal ✔ | In vitro ✔
Primarily studied in preclinical and exploratory human growth hormone modulation research contexts.
Mechanism of Action
GHRP-2 binds to the growth hormone secretagogue receptor (GHS-R1a), a G-protein–coupled receptor expressed on hypothalamic neurons and pituitary somatotroph cells. Receptor activation triggers intracellular calcium signaling and phospholipase C pathways, leading to growth hormone exocytosis. In the hypothalamus, GHRP-2 may influence neuropeptide Y and growth hormone–releasing hormone (GHRH) neurons, enhancing the amplitude of GH pulses.
Compared to GHRP-6, GHRP-2 demonstrates stronger GH release with relatively less pronounced appetite stimulation. Elevated GH stimulates hepatic IGF-1 production, which activates PI3K/Akt/mTOR signaling cascades involved in protein synthesis and cellular growth. Broader endocrine effects, including mild ACTH stimulation, have been observed in experimental settings due to ghrelin receptor cross-talk within hypothalamic networks.
Benefits
- Generates high-amplitude growth hormone pulses:
GHRP-2 is recognized for producing stronger growth hormone peaks compared to earlier GHRPs. By binding to the GHS-R1a receptor, it increases intracellular calcium signaling within pituitary somatotroph cells, triggering GH exocytosis. The resulting hormone release follows a pulsatile rhythm rather than constant elevation. Higher pulse amplitude is associated with stronger downstream IGF-1 signaling in experimental models. This amplified pulsatility differentiates GHRP-2 from milder secretagogues and supports its positioning in anabolic hormone research. - Enhances the GH–IGF-1 endocrine cascade:
Once GH is released, it stimulates hepatic production of IGF-1. IGF-1 then activates the PI3K/Akt pathway, leading to mTOR engagement and increased protein synthesis. Through this cascade, GHRP-2 indirectly influences cellular growth and structural adaptation. The sequential endocrine layering preserves physiological hierarchy, ensuring that peripheral tissues respond to naturally released hormones rather than direct receptor agonism. - Strong ghrelin receptor affinity and dual-site activation:
GHRP-2 binds to ghrelin receptors expressed both in the hypothalamus and pituitary. Hypothalamic activation enhances GHRH neuron activity while suppressing somatostatin tone, which normally inhibits GH release. Simultaneously, pituitary receptor activation directly stimulates hormone secretion. This coordinated dual-site engagement increases both frequency and amplitude of GH pulses. - Influences intracellular anabolic signaling pathways:
Elevated GH and IGF-1 levels activate intracellular pathways responsible for protein assembly and cellular growth. Akt phosphorylation promotes cell survival and inhibits apoptotic signaling. mTOR activation increases ribosomal protein translation and muscle fiber adaptation. These intracellular changes support sustained anabolic signaling environments in controlled research settings. - Supports muscle recovery and structural adaptation:
Growth hormone influences collagen synthesis, connective tissue remodeling, and muscle repair signaling. By stimulating endogenous GH release, GHRP-2 activates repair-associated endocrine pathways. IGF-1 contributes to satellite cell activation and differentiation, supporting structural muscle adaptation in laboratory models. - Moderate appetite pathway engagement compared to GHRP-6:
Although GHRP-2 activates the same ghrelin receptor as GHRP-6, appetite stimulation tends to be less pronounced. Hypothalamic neuropeptide Y signaling may still be influenced, but the primary observed effect is GH amplification. This distinction positions GHRP-2 as a more hormone-focused secretagogue rather than a hunger-driven peptide. - Integrates with broader hypothalamic-pituitary networks:
Activation of the ghrelin receptor influences interconnected neuroendocrine circuits. Experimental observations suggest mild ACTH modulation due to hypothalamic cross-talk. This broader endocrine integration reflects the complexity of central hormone regulation and differentiates GHRP-2 from highly selective secretagogues. - Creates cumulative anabolic exposure over repeated pulses:
Repeated amplification of GH pulses increases cumulative IGF-1 exposure. This sustained endocrine environment enhances activation of growth-related intracellular pathways. Over time, continued pulsatile stimulation may promote adaptive signaling responses within tissues studied in anabolic research models. - Preserves endogenous feedback regulation:
Because GHRP-2 stimulates natural hormone release rather than supplying exogenous GH, hypothalamic feedback loops remain active. Somatostatin release continues to regulate pulse frequency, maintaining physiological control. This preservation of feedback integrity is important in long-term endocrine modulation research.
Research Data
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Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 7°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS cold-chain transport boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not support merchants in this field.
For this reason, we accept bank transfers only.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day (cut-off dependent).
This method ensures compliance, security, and continuity of service for all customers across the EU.
