{"id":43677,"date":"2026-10-07T22:24:07","date_gmt":"2026-10-07T22:24:07","guid":{"rendered":"https:\/\/peptidepowereu.is\/?post_type=product&#038;p=43677"},"modified":"2026-10-07T22:26:34","modified_gmt":"2026-10-07T22:26:34","slug":"pnc-27","status":"publish","type":"product","link":"https:\/\/peptidepowereu.is\/fr\/pnc-27\/","title":{"rendered":"PNC-27"},"content":{"rendered":"<p><strong>PNC-27<\/strong> est un <strong>peptide synth\u00e9tique chim\u00e9rique<\/strong> compos\u00e9 d&rsquo;un segment de 15 r\u00e9sidus provenant du <strong>domaine de liaison HDM-2 (MDM2) de p53 (r\u00e9sidus 12-26)<\/strong> fusionn\u00e9 \u00e0 un peptide de r\u00e9sidence membranaire (MRP) d\u00e9riv\u00e9 de la p\u00e9n\u00e9tratine. Cette conception structurelle est \u00e9tudi\u00e9e in vitro pour son interaction avec HDM-2 associ\u00e9 \u00e0 la membrane et son influence sur l&rsquo;organisation de la bicouche lipidique dans des lign\u00e9es cellulaires cultiv\u00e9es exprimant HDM-2 \u00e0 la membrane plasmique.<\/p>\n<p>Dans la recherche exp\u00e9rimentale in vitro, PNC-27 a \u00e9t\u00e9 observ\u00e9 pour <strong>interagir avec la membrane plasmique<\/strong> de lign\u00e9es cellulaires cultiv\u00e9es pr\u00e9sentant HDM-2 \u00e0 la surface membranaire, o\u00f9 le segment MRP ancre le peptide et favorise la <strong>formation de pores transmembranaires<\/strong>. Des \u00e9tudes ont caract\u00e9ris\u00e9 ces interactions membranaires dans plusieurs mod\u00e8les de lign\u00e9es cellulaires cultiv\u00e9es.<\/p>\n<p>Des investigations m\u00e9canistiques ont \u00e9galement explor\u00e9 l&rsquo;influence de PNC-27 sur <strong>l&rsquo;organisation du cholest\u00e9rol membranaire<\/strong> et son comportement conformationnel aux interfaces lipidiques, distinguant sa conception de r\u00e9sidence membranaire des peptides classiques d\u00e9riv\u00e9s de p53 intracellulaires.<\/p>\n<p>Fourni sous forme de <strong>stylo injecteur pr\u00eat \u00e0 l&#8217;emploi<\/strong> (solution de 2 mL, 1 clic = 0,01 mL) \u00e0 <strong>&gt;98% de puret\u00e9 HPLC<\/strong>, PNC-27 est destin\u00e9 exclusivement \u00e0 la manipulation en laboratoire et aux essais in vitro ; aucun protocole de dosage de recherche n&rsquo;est publi\u00e9 et aucune dose n&rsquo;est recommand\u00e9e (voir la section Dosage).<\/p>\n<p><strong>Statut clinique :<\/strong><br \/>\nPNC-27 est un <strong>peptide de recherche<\/strong> \u00e9tudi\u00e9 exclusivement dans des \u00e9tudes pr\u00e9cliniques in vitro portant sur la liaison \u00e0 HDM-2 et la formation de pores membranaires. Il n&rsquo;est pas approuv\u00e9 pour un usage m\u00e9dical et reste r\u00e9serv\u00e9 \u00e0 la <strong>recherche en laboratoire et exp\u00e9rimentale<\/strong>.<\/p>\n<p><strong>Type de preuves :<\/strong><br \/>\nEssai clinique \u2610 | Observationnel \u2610 | Animal \u2714 | In vitro \u2714 | R\u00e9glementaire \u2610<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PNC-27 est un peptide synth\u00e9tique chim\u00e9rique compos\u00e9 d&rsquo;un segment de 15 r\u00e9sidus provenant du domaine de liaison HDM-2 (MDM2) de<\/p>\n","protected":false},"featured_media":43688,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[494],"product_tag":[],"class_list":["post-43677","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-aging-longevity-research","first","instock","shipping-taxable","purchasable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/peptidepowereu.is\/fr\/wp-json\/wp\/v2\/product\/43677","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptidepowereu.is\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/peptidepowereu.is\/fr\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":1,"href":"https:\/\/peptidepowereu.is\/fr\/wp-json\/wp\/v2\/product\/43677\/revisions"}],"predecessor-version":[{"id":43712,"href":"https:\/\/peptidepowereu.is\/fr\/wp-json\/wp\/v2\/product\/43677\/revisions\/43712"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peptidepowereu.is\/fr\/wp-json\/wp\/v2\/media\/43688"}],"wp:attachment":[{"href":"https:\/\/peptidepowereu.is\/fr\/wp-json\/wp\/v2\/media?parent=43677"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/peptidepowereu.is\/fr\/wp-json\/wp\/v2\/product_brand?post=43677"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/peptidepowereu.is\/fr\/wp-json\/wp\/v2\/product_cat?post=43677"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/peptidepowereu.is\/fr\/wp-json\/wp\/v2\/product_tag?post=43677"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}