{"id":39125,"date":"2026-06-21T10:20:00","date_gmt":"2026-06-21T10:20:00","guid":{"rendered":"https:\/\/peptidepowereu.is\/?post_type=product&#038;p=39125"},"modified":"2026-06-21T11:03:33","modified_gmt":"2026-06-21T11:03:33","slug":"aicar","status":"publish","type":"product","link":"https:\/\/peptidepowereu.is\/es\/aicar\/","title":{"rendered":"AICAR"},"content":{"rendered":"<p><strong>AICAR<\/strong> (5-Aminoimidazole-4-carboxamide ribonucleotide) is a <strong>cell-permeable nucleotide analog<\/strong> and a direct <strong>activator of AMP-activated protein kinase (AMPK)<\/strong>, a master regulator of cellular energy homeostasis. It is widely studied as a research compound for its ability to mimic the metabolic state of exercise and caloric restriction in experimental models.<\/p>\n<p>In preclinical studies, AICAR has been observed to <strong>enhance fatty acid oxidation<\/strong>, <strong>stimulate mitochondrial biogenesis<\/strong>, and <strong>increase glucose uptake<\/strong> in skeletal muscle independently of insulin signaling. Through activation of AMPK, it modulates downstream pathways including <strong>PGC-1\u03b1<\/strong>, <strong>ACC<\/strong>, and <strong>mTOR<\/strong>, shifting cellular metabolism toward catabolic, energy-producing processes.<\/p>\n<p>AICAR has also been investigated for its effects on <strong>endurance capacity<\/strong>, <strong>muscle fiber-type transition<\/strong>, and <strong>metabolic adaptation<\/strong> in rodent models, often referred to in literature as an \u00abexercise mimetic.\u00bb Additional research has explored its role in <strong>cardioprotection<\/strong>, <strong>anti-inflammatory signaling<\/strong>, and <strong>glucose regulation<\/strong> in models of metabolic dysfunction.<\/p>\n<p>Supplied as a <strong>lyophilized powder<\/strong> for reconstitution, AICAR is intended for in vitro and in vivo laboratory applications under controlled experimental conditions.<\/p>\n<p><strong>Clinical Status:<\/strong><br \/>\nAICAR is a <strong>research compound<\/strong> studied extensively in animal models and in vitro systems for AMPK activation, metabolic modulation, and exercise mimetic effects. It is not approved for human medical or therapeutic use and remains restricted to <strong>experimental and laboratory research<\/strong>. AICAR is listed on the WADA Prohibited List as a metabolic modulator in competitive sport.<\/p>\n<p><strong>Evidence type:<\/strong><br \/>\nHuman RCT \u2610 | Observational \u2610 | Animal \u2714 | In vitro \u2714 | Regulatory \u2714<\/p>\n","protected":false},"excerpt":{"rendered":"<p>AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a cell-permeable nucleotide analog and a direct activator of AMP-activated protein kinase (AMPK), a master regulator<\/p>\n","protected":false},"featured_media":39511,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[300,301],"product_tag":[],"class_list":["post-39125","product","type-product","status-publish","has-post-thumbnail","product_cat-mitochondrial-health-cellular-energy-research","product_cat-weight-loss-metabolic-optimization-research","first","instock","shipping-taxable","purchasable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/peptidepowereu.is\/es\/wp-json\/wp\/v2\/product\/39125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptidepowereu.is\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/peptidepowereu.is\/es\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":1,"href":"https:\/\/peptidepowereu.is\/es\/wp-json\/wp\/v2\/product\/39125\/revisions"}],"predecessor-version":[{"id":39512,"href":"https:\/\/peptidepowereu.is\/es\/wp-json\/wp\/v2\/product\/39125\/revisions\/39512"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peptidepowereu.is\/es\/wp-json\/wp\/v2\/media\/39511"}],"wp:attachment":[{"href":"https:\/\/peptidepowereu.is\/es\/wp-json\/wp\/v2\/media?parent=39125"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/peptidepowereu.is\/es\/wp-json\/wp\/v2\/product_brand?post=39125"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/peptidepowereu.is\/es\/wp-json\/wp\/v2\/product_cat?post=39125"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/peptidepowereu.is\/es\/wp-json\/wp\/v2\/product_tag?post=39125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}