BPC-157 & TB-500
Price range: $130.80 through $205.20
BPC-157 & TB-500 - Targeted Repair & Systemic Regeneration
Description
BPC-157 (Body Protection Compound-157) is a gastric-derived pentadecapeptide shown in preclinical studies to accelerate the healing of tendons, ligaments, muscles, and intestinal tissues. It modulates growth factor expression and enhances fibroblast migration to injury sites.
TB-500 (Thymosin Beta-4 fragment) complements these effects by promoting actin up-regulation, angiogenesis, and cell migration, facilitating faster tissue remodeling and improved microcirculation.
When combined, the two peptides demonstrate a dual-mechanism synergy: BPC-157 supports local tissue regeneration and anti-inflammatory balance, while TB-500 enhances cellular motility and vascular repair, together amplifying regenerative outcomes beyond either peptide alone.
Mechanism of Action
BPC-157 has been observed to increase VEGF signaling, fibroblast migration, and modulate nitric oxide pathways for improved tissue perfusion. TB-500 stimulates cell migration through actin-binding, promoting regrowth and repair of injured or inflamed tissues. Their combined use in research demonstrates cytoskeletal and angiogenic synergy – ideal for complex tissue restoration.
Benefits
- Synergistic Acceleration of Tissue Repair:
The combination of BPC-157 and TB-500 has been studied for its synergistic ability to accelerate the repair of muscle, tendon, and ligament injuries. BPC-157 enhances angiogenesis and fibroblast activation, while TB-500 promotes actin polymerization and cell migration. Together, they support faster restoration of tissue integrity and biomechanical strength, making this pairing a gold standard in regenerative research models. - Enhanced Angiogenesis and Blood Flow Restoration:
Both peptides are observed to promote angiogenesis, increasing the formation of new capillaries in injured regions. TB-500 upregulates VEGF and actin-binding proteins, whereas BPC-157 improves endothelial repair and vascular stability. Their combination ensures optimal oxygen and nutrient delivery, significantly improving tissue recovery time and quality. - Reduction of Inflammation and Oxidative Stress:
BPC-157 and TB-500 work synergistically to reduce inflammatory cytokines such as TNF-α and IL-6 and to mitigate oxidative stress markers in damaged tissues. This dual anti-inflammatory action protects cellular structures from degradation and supports homeostatic recovery after trauma, surgery, or repetitive strain injuries. - Promotion of Muscle Regeneration and Performance Recovery:
Studies suggest that the combination enhances myoblast differentiation and muscle fiber regeneration following trauma or exercise-induced injury. TB-500’s role in cellular migration complements BPC-157’s capacity for angiogenic and collagen-based repair, together facilitating faster muscular restoration, improved endurance, and reduced post-exertional fatigue in experimental recovery models. - Improved Collagen Synthesis and Structural Integrity:
BPC-157 stimulates collagen fiber synthesis and fibroblast activation, while TB-500 promotes cellular alignment and remodeling of the extracellular matrix. The result is a denser, more organized tissue structure that exhibits higher tensile strength and better resistance to re-injury. This makes the combination particularly interesting for tendon and ligament regeneration studies. - Acceleration of Joint and Connective Tissue Healing:
Research indicates that both peptides support cartilage and synovial tissue repair. BPC-157 has shown protection against degenerative joint changes, while TB-500 improves cell migration and reduces fibrosis. Their joint use enhances chondrocyte viability and promotes a more stable joint microenvironment conducive to long-term recovery. - Neuroprotective and Peripheral Nerve Recovery Effects:
The BPC-157 & TB-500 stack demonstrates neuroprotective potential by improving axonal regeneration and neuromuscular coordination following peripheral nerve injuries. BPC-157 contributes to neurotrophic signaling and dopamine regulation, while TB-500 enhances actin-based neuronal outgrowth, resulting in faster restoration of nerve conduction and motor function. - Enhanced Wound Healing and Skin Regeneration:
Experimental models show that the combination accelerates cutaneous wound closure through coordinated angiogenesis, epithelialization, and fibroblast proliferation. The result is improved wound stability, reduced scar formation, and stronger tissue remodeling, supporting its exploration in both trauma and cosmetic regenerative research. - Support for Organ and Vascular Protection:
BPC-157 has shown protective effects on liver, heart, and gastrointestinal tissues, while TB-500 improves endothelial cell repair and reduces ischemic injury. Together, they provide systemic protective effects across multiple organs, maintaining vascular integrity and reducing reperfusion-related oxidative damage in experimental ischemia models. - Synergy in Cytoskeletal and Cellular Migration Mechanisms:
At the cellular level, TB-500 enhances actin polymerization and cell motility, while BPC-157 stabilizes the extracellular matrix and promotes fibroblast adhesion. This mechanistic complementarity leads to a more efficient wound healing cascade, facilitating rapid closure and organized tissue reconstruction under experimental conditions. - Potential for Combined Regenerative Protocols:
The BPC-157 & TB-500 combination is frequently studied as a core regenerative stack in synergy with GHK-Cu or SS-31 for mitochondrial and collagen support. This approach is used to explore multi-pathway recovery involving angiogenesis, oxidative stress reduction, and cellular energy optimization across complex injury and aging models.
Research Data
| Study/model | Reported effect |
| Rat Achilles tendon transection |
Faster collagen fiber alignment and fibroblast proliferation by day 7-10; tensile strength ~30-40% higher vs control.
|
| Rodent medial collateral ligament injury |
Improved ligament histology and biomechanical strength; reduced scar tissue density vs saline.
|
| Skeletal muscle contusion (mouse) |
Earlier myofiber regeneration with denser cross-linking and smaller necrotic zones by day 14.
|
| Full-thickness skin wound (rodent) |
↑ capillary density and re-epithelialization rate; combined use outperforms single-peptide arms.
|
| Angiogenesis assays (preclinical) |
TB-500 ↑ VEGF signaling and endothelial migration; BPC-157 stabilizes vasculature → net ↑ perfusion.
|
| Inflammation models (cell/rodent) |
↓ TNF-α, IL-6 and oxidative stress markers; pro-repair cytokine profile supports tissue remodeling.
|
| Tendon fibroblast and ECM markers (in vitro) |
↑ fibroblast migration and collagen I/III organization; improved FAK-paxillin pathway signaling.
|
| Peripheral nerve crush (rodent) |
Trends toward faster functional recovery and axonal sprouting alongside improved local perfusion.
|
| GI mucosal injury (rodent) |
BPC-157 contributes gut barrier protection; pairing with TB-500 maintains microcirculatory flow.
|
| Overuse/strain models (rodent) |
Reduced time to functional recovery and lower edema scores; supports maintenance protocols.
|
Stack Suggestions
- Commonly stacked with: GHK-Cu, SS-31, or Epithalon for enhanced cellular repair and mitochondrial support.
- Mechanistic rationale:
BPC-157 + GHK-Cu → fibroblast activation + collagen signaling,
TB-500 + SS-31 → vascular protection + mitochondrial resilience.
Pen Dosage Chart
| BPC-157 + TB-500 Pen 5 + 5 mg | |
| Volume | 2.0 mL |
| mg/mL | 5 mg/mL |
| Click-to-Dose | 1 click = 0.05 mg |
| Example(s) | 10 clicks = 0.5 mg; 50 clicks = 2.5 mg |
| BPC-157 + TB-500 Pen 10 + 10 mg | |
| Volume | 2.0 mL |
| mg/mL | 10 mg/mL |
| Click-to-Dose | 1 click = 0.10 mg |
| Example(s) | 10 clicks = 1 mg; 25 clicks = 2.5 mg |
Dosage & Protocols Variations
Standard Research Protocol
- Dose: 0.5 – 1 mg
- Duration: 4 – 6 weeks
- Frequency: 1× daily
- Cycle Interval: 4 week rest
- Goal / Description: Basic tissue recovery support model
Enhanced Regeneration Protocol
- Dose: 1 – 1.5 mg
- Duration: 8 – 12 weeks
- Frequency: Every other day
- Cycle Interval: 4 week rest
- Goal / Description: Designed for extended regenerative studies, emphasizing vascular and muscular adaptation
Post-Load Model
- Dose: 2 mg
- Duration: 2 – 4 weeks
- Frequency: 1× daily
- Cycle Interval: 2 week rest
- Goal / Description: Applied in post-strain or high-load experimental recovery
Biohacker Protocol
- Dose: 0.5 mg
- Duration: Continuous
- Frequency: 5× weekly
- Cycle Interval: 2 week rest
- Goal / Description: Experimental long-term maintenance design emphasizing consistent angiogenic response
Possible Side Effects
The BPC-157 & TB-500 blend, as research peptides involved in regeneration, may elicit side effects in experimental models, mainly at injection sites or systemically. Effects are typically mild and dose-related, with subcutaneous administration sometimes causing local responses. Close monitoring is essential.
Injection Site Reactions: Common observations include redness, swelling, or pain at the site, resolving within days. Rotating areas and proper technique minimize this.
Nausea or Gastrointestinal Upset: Mild queasiness may occur, linked to BPC-157’s gastric origins, especially at higher doses. It subsides with adaptation.
Fatigue or Dizziness: Transient lethargy has been noted early on, possibly from metabolic shifts or inflammation reduction. This resolves as models stabilize.
Headache: Occasional mild headaches, attributed to vascular changes from angiogenesis promotion.
Most side effects are transient and manageable via dose adjustment in research. Limited data suggest vigilance for potential long-term effects like overgrowth, though rare in controlled animal studies.
Product Attributes
- CAS #: BPC-157: 137525-51-0; TB-500: 77591-33-4
- Molecular Formula: BPC-157: C62H98N16O22; TB-500: C212H350N56O78S
- Sequence (AA): BPC-157: GEPPPGKPADDAGLV; TB-500: Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
- Molecular Weight: BPC-157: ~1419 g/mol; TB-500: ~4963 g/mol
- PubChem CID: BPC-157: 9941957; TB-500: 16132327
- Half-Life: BPC-157: ~4 – 6 hours; TB-500: ~8 – 12 hours
- Synonyms: Thymosin Beta-4 Fragment, Body Protection Compound-157, Pentadecapeptide BPC-157
- Type: Research peptide blend
- Research Focus: Recovery & Performance
Scientific References
- Intra-articular injection of BPC 157 for multiple types of knee pain Animal
- Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon Animal
- BPC157 as potential agent rescuing from cancer cachexia In vitro
- Thymosin β4: a multi-functional regenerative peptide Animal
- Pentadecapeptide BPC 157 cream improves burn-wound healing Animal
- Pentadecapeptide BPC 157 enhances the growth hormone receptor expression In vitro
- Emerging use of BPC-157 in orthopaedic sports medicine Observational
- Pharmacokinetics, distribution, metabolism, and excretion of body protective compound-157 Animal
- Novel wellbeing and repair peptide use in the UK Observational
- BPC 157 | 137525-51-0 – ChemicalBook In vitro
Included In The Box
Every product arrives in a premium, custom-designed PEPTIDE.Power box, engineered for convenience, hygiene, and safe storage in your refrigerator. Inside, you will find everything needed for your full research protocol:
- 1× Disposable Pre-Mixed Injection Pen
- Powered by our proprietary PSM Technology™ – precision stabilization & mixing system for consistent potency
- 10× Ultra-thin Needles (33G, 4 mm)
- 10× Alcohol Pads for sterile preparation
- Internal Stabilizing Foam Insert to prevent shaking during transport
- Instruction Panel printed on the inside of the box for quick reference
- Security Seal Sticker ensuring the package has not been opened or tampered with
Storage
Store the product in a refrigerator at 1 – 7°C immediately upon delivery. To maintain optimal stability, keep the pen away from light, and do not expose it to repeated temperature changes.
Once reconstituted (all our pens come pre-mixed), research compounds remain stable for 6 – 8 weeks under proper refrigeration.
Do not freeze after reconstitution. Always keep the box closed so the pen, needles, and alcohol pads stay clean and protected.
For best results, use the product consistently within the recommended time window and always follow your research protocol.
Delivery
We ship with Next-Day EU Delivery via DHL Express or UPS Express.
All orders are prepared fresh on the day of dispatch, placed in EPS cold-chain transport boxes, and shipped with cooling elements to maintain a stable temperature throughout the journey.
Our logistics process is designed so the package arrives overnight, avoiding customs delays inside the European Union.
Products are shipped from our EU facility, ensuring no import duties, no customs clearance, and always fast and secure delivery.
Payment
Due to the nature of research peptides and the high-risk category assigned by payment processors, credit card companies do not support merchants in this field.
For this reason, we accept bank transfers only.
Within the European Union, SEPA transfers are fast, low-cost, and usually arrive within minutes to a few hours, making the payment process smooth and simple.
Once the transfer is received, your order is prepared immediately and dispatched the same day (cut-off dependent).
This method ensures compliance, security, and continuity of service for all customers across the EU.
